Katharine J Bar, MD

faculty photo
Assistant Professor of Medicine
Department: Medicine
Graduate Group Affiliations

Contact information
502 D Johnson Pavilion
3610 Hamilton Walk
Philadelphia, PA 19104-6073
Office: (215) 573-8497
Fax: (215) 349-5111
Education:
BA (Biochemistry and African History, Honors)
Northwestern University, Evanston, IL, 1997.
MD
University of Iowa College of Medicine, Iowa City, IA, 2002.
Permanent link
 

Description of Research Expertise

We study the basic mechanisms of transmission, pathogenesis and persistence in HIV and other chronic viral infections.

Current projects include:

1. The HIV transmission bottleneck and virus phenotype in injection drug users

2. The viral dynamics of rebound viremia upon cART interruption, both in the presence and absence of treatment and curative strategies

3. The neutralization properties of SIV challenge swarms and their transmitted/founder viruses

4. The genetic signatures of Herpes Simplex Virus immune escape from vaccine pressure


Lab Personnel:

Benjamin Scheinfeld, technician
D. Brenda Salantes, graduate student

Selected Publications

Barbian HJ, Jackson-Jewett R, Brown CS, Bibollet-Ruche F, Learn GH, Decker T, Kreider EF, Li Y, Denny TN, Sharp PM, Shaw GM, M.D., Lifson JD, Acosta EP, Saag MS, Bar KJ, Hahn BH: Effective Treatment of SIVcpz-Induced Immunodeficiency in a Captive Western Chimpanzee. Retrovirology 14(1): 35, June 2017.

Fan Li, Liying Ma, Yi Feng, Yuhua Ruan, Jing Hu, Hongsuo Song, Pengtao Liu, Jun Ma, Baolin Rui, Kate Kerpen, Benjamin Scheinfeld, Tuhina Srivastava, David Metzger, Hui Li, Katharine J. Bar, Yiming Shao: HIV-1 and hepatitis C virus selection bottleneck in Chinese people who inject drugs. AIDS 2017.

Bar KJ, Sneller MC, Harrison LJ, Justement SJ, Overton ET, Petrone ME, Salantes BD, Seamon CA, Scheinfeld B, Kwan RW, Learn GH, Proschan MA, Kreider EF, Bazkova J, Bardsley M, Refsland EW, Messer M, Clarridge KE, Tustin NB, Madden PJ, Oden KS, O'Dell SJ, Jarocki B, Shiakolas AR, Tressler RL, Doria-Rose NA, Bailer RT, Ledgerwood JE, Capparelli EV, Lynch RM, Graham BS, Moir S, Koup RA, Mascola JR, Hoxie JA, Fauci AS, Tebas P, Chun T-W: Effect of HIV Antibody VRC01 on Viral Rebound after Treatment Interruption. NEJM 375(21): 2037-2050, Nov 2016.

Lopker MJ, Del Prete GQ, Estes JD, Li H, Reid C, Newman L, Lipkey L, Camus C, Easlick JL, Wang S, Decker JM, Bar KJ, Learn G, Pal R, Weiss DE, Hahn BH, Lifson JD, Shaw GM, Keele BF: Derivation and Characterization of Pathogenic Transmitted/Founder Molecular Clones from Simian Immunodeficiency Virus SIVsmE660 and SIVmac251 following Mucosal Infection. J Virol 90(19): 8435-53, Oct 2016.

Salazar-Gonzalez JF, Salazar MG, Tully DC, Ogilvie CB, Learn GH, Allen TM, Heath SL, Goepfert P, Bar KJ: Use of dried blood spots to elucidate full-length transmitted/founder HIV-1 genomes. Pathogens and Immunity 1(1): 129-153, July 2016.

Jiao Y, Zhang X, Wang C, Li L, Liu J, Bar KJ, Wei H, Hu Y, Huang P, Zeng Z, Jiang S, Du J, Shao Y, Metzger D, Li S, Ma L: Hepatitis C Virus Subtype and Evolution Characteristic Among Drug Users, Men Who Have Sex With Men, and the General Population in Beijing, China. Medicine 95(6): e2688, Feb 2016.

Lee FH, Mason R, Welles H, Learn GH, Keele BF, Roederer M, Bar KJ: Breakthrough virus neutralization resistance as a correlate of protection in a nonhuman primate heterologous SIV vaccine challenge study. J Virol 89(24): 12388-400, Dec 2015.

Sterret S, Edlefsen PT, Learn GH, Haynes BF, Hahn BH, Shaw GM and Bar KJ: Low multiplicity of HIV-1 infection and no vaccine enhancement in VAX003 injection drug users. Open Forum Infect Dis 1(2): ofu056, Sept 2014.

Li H, Blair L, Chen Y, Learn G, Pfafferott K, John M, Bhattacharya T, Hahn BH, Mallal S, Shaw GM, Bar KJ: Molecular mechanisms of HIV-1 prophylaxis failure revealed by single genome sequencing. J Inf Dis 208(10): 1598-1603, November 2013.

Lopker M, Easlick J, Sterrett S, Decker JM, Barbian, Learn G, Keele BF, Robinson JE, Li H, Hahn BH, Shaw GM and Bar KJ : Heterogeneity in neutralization sensitivity of viruses comprising the simian immunodeficiency virus SIVsmE660 isolate and vaccine challenge stock. J Virol 87(10): 5477-92, May 2013.

back to top
Last updated: 11/21/2017
The Trustees of the University of Pennsylvania