Rahim R. Rizi, Ph.D.

faculty photo
Professor of Radiology
Department: Radiology
Graduate Group Affiliations

Contact information
Department of Radiology
1 Silverstein
3400 Spruce Street
Philadelphia, PA 19104-6100
Office: 215-573-0891
Fax: 215-349-5115
B.S. (Chemistry)
University of Isfahan, Iran, 1976.
M.S. (Physical Chemistry)
Western Illinois University, 1978.
Ph.D. (Physical Chemistry)
University of Iowa , 1983.
M.S. (Computer Science)
University of Pennsylvania , 1987.
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Description of Research Expertise

The primary mission of the Functional and Metabolic Imaging Group (FMIG) is the development and application of novel hyperpolarized MRI techniques to the diagnosis of various pulmonary and metabolic disorders. Hyperpolarization, the process of drastically increasing the population difference between nuclear spin states, provides a platform for imaging lung physiology and metabolic activity with spatial and temporal resolution unattainable with conventional MRI techniques, thus offering the potential for the earlier diagnosis of disease states and the precise monitoring of a patient’s response to medical treatment. This core research theme is executed with an eye toward several ultimate goals: the identification of changes in pulmonary structure and function associated with disease, a more complete understanding of pathogenesis, and the establishment of a more sensitive testing environment to develop treatments for lung disease. To date, significant contributions in these areas include new imagining techniques for the comprehensive description of lung physiology and structure, accurate imaging of the regional pulmonary partial pressure of oxygen in both humans and large and small animals, highly developed imaging of regional ventilation, and a state-of-the-art mechanical ventilation device. Specifically, our research activities at FMIG is divided into four general branches: 1) The development of novel imaging techniques for the quantitative assessment of pulmonary structure and function: 2)The development of novel methods for real-time metabolic imaging: 3)The construction of novel polarization apparatuses: 4) The development and implementation of rapid imaging pulse sequences.

Selected Publications

Ardenkjaer-Larsen Jan H, Laustsen C, Bowen S, Rizi RR: Hyperpolarized H2O MR angiography. Magnetic Reson. in Med Jan 2014.

Cereda M, Xin Y, Emami K, Huang J, Rajaei J, Profka H, Han B, Mongkolwisetwara P, Kadlecek S, Kuzma N, Pickup S, Ishii M, Kavanagh B, Deutschman C, Rizi RR, : Positive End-expiratory Pressure Increments during Anesthesia in Normal Lung Result in Hysteresis and Greater Numbers of Smaller Aerated Air. Anesthesiology In Press, Dec 2013.

Hamedani H, Kadlecek S, Ishii M, Emami K, Kuzma N, Xin Y, Rossman M, Rizi RR: A Variability Study of Regional Alveolar Oxygen Tension Measurement in Humans Using Hyperpolarized 3He MRI. Magn Reson Med Dec 2013.

Emami K, Xu Y, Hamedani H, Profka H, Kadlecek S, Xin Y, Ishii M, Rizi RR: Accelerated Fractional Ventilation Imaging with Hyperpolarized Gas MRI. Magn Reson Med Nov 2013.

Kadlecek S, Hamedani H, Xu Y, Emami K, Xin Y, Ishii M, Rizi RR: Regional Aveolar Partial Pressure of Oxygen Measurement with Parallel Accelerated Hyperpolarized Gas MRI Academic Radiology Oct 2013.

Pourfathi M, Kuzma NN, Kara H, Ghosh RK, Shaghaghi H, Kadlecek SJ, Rizi RR: Propagation of Dynamic Nuclear Polarization across the Xenon Cluster Boundaries: Elucidation of the Spin-Diffusion Bottleneck. J Magn Reson Oct 2013.

Lin LZ, Kadlececk S, Xu HN, Daye D, Pullinger B, Chodosh L, Rizi RR: Ratiometric analysis in hyperpolarized NMR (I): Test of the two-site exchange model and the reaction rate. NMR in Biomedicine Oct 2013.

Kuzma NN, Håkansson P, Pourfathi M, Ghosh RK, H. Kara H, Kadlecek SJ, Pileio G, Levitt MH, Rizi RR: Lineshape-based polarimetry of dynamically-polarized 15N2O in solid-state mixtures. J Magn Reson Sept 2013.

Cereda M, Emami K, Xin Y, Kadlecek S, Kuzma N, Mongkolwisetwara, Profka H, Pickup S, Ishii M, Kavanagh B, Deutschman C, Rizi RR: Imaging the interaction of atelectasis and over-distention in surfactant depleted lungs. Crit Care Med 41(2): 527-35, Feb 2013.

Pullinger B, Profka H, Ardenkjaer-Larsen J, Kuzma N, Kadlecek S, and Rizi R: Metabolism of Hyperpolarized [1-13C]Pyruvate in the Isolated Perfused Rat Lung – An Ischemia Study. NMR Biomed Page: 1113-1118, Oct 2012.

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Last updated: 01/10/2014
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