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Faculty Members: 
Brian Litt, MD
Professor of Neurology
Attending Neurologist, Hospital of the University of Pennsylvania
Co-Director, Master's Degree Program, University of Pennsylvania, Department of Bioengineering
Interim Director, Penn Epilepsy Center, Hospital of the University of Pennsylvania
Department: Neurology
Contact information
Hospital: HUP
3 West Gates / 4283
34th Spruce Street
Lab: 301 Hayden Hall
3320 Smith Walk
Philadelphia, PA 19104
3 West Gates / 4283
34th Spruce Street
Lab: 301 Hayden Hall
3320 Smith Walk
Philadelphia, PA 19104
Office: (215) 746-4850
Fax: (215)-349-5733
Fax: (215)-349-5733
Email:
littb@mail.med.upenn.edu
littb@mail.med.upenn.edu
Graduate Group Affiliations
Publications
Links
Search PubMed for articles
PennBrain
Institute of Neurological Sciences Faculty
Penn Neuroengineering Research Lab
Lab Web Page
Search PubMed for articles
PennBrain
Institute of Neurological Sciences Faculty
Penn Neuroengineering Research Lab
Lab Web Page
Education:
A.B.
Harvard University Cum Laude, Engineering and Applied Sciences, 1982.
M.D. ( )
Johns Hopkins University School of Medicine, 1986.
A.B.
Harvard University Cum Laude, Engineering and Applied Sciences, 1982.
M.D. ( )
Johns Hopkins University School of Medicine, 1986.
Post-Graduate Training
Intern, Internal Medicine, Johns Hopkins Hospital, Baltimore, MD, 1986-1987.
Dana Foundation Fellowship, Magnetoencephalography, Johns Hopkins University Applied Physics Laboratory, 1987-1988.
Resident in Neurology, Johns Hopkins Hospital, Baltimore, MD, 1988-1991.
Chief Resident, Neurology, Johns Hopkins Hospital, Baltimore, MD, 1990-1991.
Fellow, Epilepsy and Clinical Neurophysiology, Johns Hopkins Hospital, Baltimore, MD, 1991-1993.
Intern, Internal Medicine, Johns Hopkins Hospital, Baltimore, MD, 1986-1987.
Dana Foundation Fellowship, Magnetoencephalography, Johns Hopkins University Applied Physics Laboratory, 1987-1988.
Resident in Neurology, Johns Hopkins Hospital, Baltimore, MD, 1988-1991.
Chief Resident, Neurology, Johns Hopkins Hospital, Baltimore, MD, 1990-1991.
Fellow, Epilepsy and Clinical Neurophysiology, Johns Hopkins Hospital, Baltimore, MD, 1991-1993.
Certifications
American Board of Psychiatry and Neurology, certificate # 036609, no expiration date., 1992.
American Board of Clinical Neurophysiology (no expiration date), 1996.
Added Qualification in Clinical Neurophysiology, American Board of Psychiatry and Neurology, certificate # 639, 1996.
Permanent linkAmerican Board of Psychiatry and Neurology, certificate # 036609, no expiration date., 1992.
American Board of Clinical Neurophysiology (no expiration date), 1996.
Added Qualification in Clinical Neurophysiology, American Board of Psychiatry and Neurology, certificate # 639, 1996.
Description of Research Expertise
Epilepsy, EEG, Clinical Neurophysiology, Epilepsy Surgery, Brain Stimulation, Implantable devices, network neuroscience, deep brain stimulation, functional imaging, neuroengineering, Biomedical engineering, computational neuroscience.Description of Clinical Expertise
Epilepsy, Status epilepticus, Epilepsy Surgery, EEG, Clinical Neurophysiology, Intraoperative Monitoring, Antiepileptic Drugs, Functional brain mapping, brain stimulation, electrocorticography, evoked potentials, EEG, MEGDescription of Other Expertise
Entrepreneurship:I have helped found the following companies:
1. IntelliMedix, Inc. Atlanta, GA ~1997
2. Bioquantix, Inc, Atlanta, GA ~2000
I consult or have consulted for the following other companies:
1. NeuroVista, Inc.
2. MC10 (agreement under review)
3. Medtronic, Inc.
4. KCI, Inc.
I am on the Scientific Advisory Board of the following companies:
1. NeuroVista, Inc.
2. MC10 (agreement pending).
I have licensed technology to the following companies:
1. NeuroPace, Inc.
2. MC10, Inc.
3. NeuroVista (under potential review)
I have participated in helping bring several implantable NeuroDevices to market.
Selected Publications
Worrell, GA, Gardner, AB, Stead, SM, Hu, SQ, Goerss, S, Cascino, GJ, Meyer, FB, Marsh, R, Litt, B: High-frequency oscillations in human temporal lobe: simultaneous microwire and clinical macroelectrode recordings. Brain 131(4): 928-937, Apr 2008.Blanco JA, Stead M, Krieger A, Viventi J, Marsh WR, Lee KH, Worrell G, Litt B: Unsupervised Classification of High-Frequency Oscillations in Human Neocortical Epilepsy and Control Patients. J Neurophysiology 104(5): 2900-2912, Nov 2010.
Viventi J, Kim DH, Moss J, Kim Y-S, Blanco J, Anetta N, Hicks A, Xiao J, Huang Y, Callans DJ, Rogers JA, Litt B: A Conformal, Bio-interfaced Class of Silicon Electronics for Mapping Cardiac Electrophysiology. Science Translational Medicine (Cover article) 2(24): 24ra22, 2010.
Viventi J, Kim D-H, Vigeland L, Frechette E, Blanco J, Kim Y-S, Avrin A, Tiruvadi V, Hwang S-W, Chamberlain A, Wulsin D, Davis K, Gelber C, Palmer L, Van der Spiegel J, Wu J, Xiao J, Huang Y, Contreras D, Rogers JA, and Litt B: Flexible, Foldable, Actively Multiplexed, High-Density Electrode Array for Mapping Brain Activity in vivo. Nature Neuroscience 14(12): 1599-605, Nov 2011.
Blanco JA, Stead M, Krieger A, Stacey W, Maus D, Marsh E, Viventi J, Lee KH, Marsh R, Litt B, Worrell GA: Data mining neocortical high-frequency oscillations in epilepsy and controls. Brain 134(Pt 10): 2948-59, October 2011 Notes: 2011 Sep 8 [Epub ahead of print]
Manning JR, Polyn SM, Baltuch GH, Litt B, Kahana MJ: Oscillatory patterns in temporal lobe reveal context reinstatement during memory search. Proc Natl Acad Sci U S A 108(31): 12893-7, Aug 2011 Notes: Epub 2011 Jul 7.
Kim DH, Lu N, Ghaffari R, Kim YS, Lee S, Xu L, Wu J, Kim RH, Song J, Liu ZJ, Viventi J, de Graff B, Elolampi B, Mansour M, Slepian M, Hwang S, Moss J, Won SM, Huang Y, Litt B, Rogers J: Materials for Multifunctional Balloon Catheters With Capabilities in Cardiac Electrophysiological Mapping and Ablation Therapy. Nature Materials 10(4): 316-23, April 2011.
