Penn Comprehensive Neuroscience Center

Faculty Members
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Brian Litt, MD

Professor of Neurology and Professor of Bioengineering
Attending Neurologist, Hospital of the University of Pennsylvania
Co-Director, Master's Degree Program, University of Pennsylvania, Department of Bioengineering
Director, Penn Epilepsy Center, Hospital of the University of Pennsylvania
Director, Center for Neuroengineering and Therapeutics, University of Pennsylvania
Department: Neurology

Contact information
Hospital: HUP
3 West Gates / 4283
34th Spruce Street

Lab: 301 Hayden Hall
3320 Smith Walk
Philadelphia, PA 19104
Office: (215) 746-4850
Fax: (215)-349-5733
Graduate Group Affiliations
Harvard University Cum Laude, Engineering and Applied Sciences, 1982.
M.D. ( )
Johns Hopkins University School of Medicine, 1986.
Post-Graduate Training
Intern, Internal Medicine, Johns Hopkins Hospital, Baltimore, MD, 1986-1987.
Dana Foundation Fellowship, Magnetoencephalography, Johns Hopkins University Applied Physics Laboratory, 1987-1988.
Resident in Neurology, Johns Hopkins Hospital, Baltimore, MD, 1988-1991.
Chief Resident, Neurology, Johns Hopkins Hospital, Baltimore, MD, 1990-1991.
Fellow, Epilepsy and Clinical Neurophysiology, Johns Hopkins Hospital, Baltimore, MD, 1991-1993.
American Board of Psychiatry and Neurology, certificate # 036609, no expiration date., 1992.
Added Qualification in Clinical Neurophysiology, American Board of Psychiatry and Neurology, certificate # 639, 1996.
American Board of Clinical Neurophysiology (no expiration date), 1996.
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Description of Research Expertise

Epilepsy, EEG, Clinical Neurophysiology, Epilepsy Surgery, Brain Stimulation, Implantable devices, network neuroscience, deep brain stimulation, functional imaging, neuroengineering, Biomedical engineering, computational neuroscience.

Description of Clinical Expertise

Epilepsy, Status epilepticus, Epilepsy Surgery, EEG, Clinical Neurophysiology, Intraoperative Monitoring, Antiepileptic Drugs, Functional brain mapping, brain stimulation, electrocorticography, evoked potentials, EEG, MEG

Description of Other Expertise


I have helped found the following companies:
1. IntelliMedix, Inc. Atlanta, GA ~1997
2. Bioquantix, Inc, Atlanta, GA ~2000

I consult or have consulted for the following other companies:
1. NeuroVista, Inc.
2. MC10 (agreement under review)
3. Medtronic, Inc.
4. KCI, Inc.

I am on the Scientific Advisory Board of the following companies:
1. NeuroVista, Inc.
2. MC10 (agreement pending).

I have licensed technology to the following companies:
1. NeuroPace, Inc.
2. MC10, Inc.
3. NeuroVista (under potential review)

I have participated in helping bring several implantable NeuroDevices to market.

Selected Publications

Worrell, GA, Gardner, AB, Stead, SM, Hu, SQ, Goerss, S, Cascino, GJ, Meyer, FB, Marsh, R, Litt, B: High-frequency oscillations in human temporal lobe: simultaneous microwire and clinical macroelectrode recordings. Brain 131(4): 928-937, Apr 2008.

Blanco JA, Stead M, Krieger A, Viventi J, Marsh WR, Lee KH, Worrell G, Litt B: Unsupervised Classification of High-Frequency Oscillations in Human Neocortical Epilepsy and Control Patients. J Neurophysiology 104(5): 2900-2912, Nov 2010.

Viventi J, Kim DH, Moss J, Kim Y-S, Blanco J, Anetta N, Hicks A, Xiao J, Huang Y, Callans DJ, Rogers JA, Litt B: A Conformal, Bio-interfaced Class of Silicon Electronics for Mapping Cardiac Electrophysiology. Science Translational Medicine (Cover article) 2(24): 24ra22, 2010.

Kim DH, Lu N, Ghaffari R, Kim YS, Lee S, Xu L, Wu J, Kim RH, Song J, Liu ZJ, Viventi J, de Graff B, Elolampi B, Mansour M, Slepian M, Hwang S, Moss J, Won SM, Huang Y, Litt B, Rogers J: Materials for Multifunctional Balloon Catheters With Capabilities in Cardiac Electrophysiological Mapping and Ablation Therapy. Nature Materials 10(4): 316-23, April 2011.

Blanco JA, Stead M, Krieger A, Stacey W, Maus D, Marsh E, Viventi J, Lee KH, Marsh R, Litt B, Worrell GA: Data mining neocortical high-frequency oscillations in epilepsy and controls. Brain 134(Pt 10): 2948-59, October 2011 Notes: 2011 Sep 8 [Epub ahead of print]

Manning JR, Polyn SM, Baltuch GH, Litt B, Kahana MJ: Oscillatory patterns in temporal lobe reveal context reinstatement during memory search. Proc Natl Acad Sci U S A 108(31): 12893-7, Aug 2011 Notes: Epub 2011 Jul 7.

Viventi J, Kim D-H, Vigeland L, Frechette E, Blanco J, Kim Y-S, Avrin A, Tiruvadi V, Hwang S-W, Chamberlain A, Wulsin D, Davis K, Gelber C, Palmer L, Van der Spiegel J, Wu J, Xiao J, Huang Y, Contreras D, Rogers JA, and Litt B: Flexible, Foldable, Actively Multiplexed, High-Density Electrode Array for Mapping Brain Activity in vivo. Nature Neuroscience 14(12): 1599-605, Nov 2011.

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Last updated: 06/23/2015
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