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Yvette I. Sheline, M.D.

McLure Professor of Psychiatry and Behavioral Research
Director, Center for Neuromodulation in Depression and Stress (CNDS)
Department: Psychiatry

Contact information
Department of Psychiatry
University of Pennsylvania
Perelman School of Medicine
3535 Market St.
Philadelphia, PA 19104
B.A. (Biology)
Harvard, 1974.
M.S. (Physiology)
Yale University, 1975.
Boston University, 1979.
Post-Graduate Training
Resident in Psychiatry, Beth Israel Hospital Harvard University Boston, MA, 1980-1983.
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> Perelman School of Medicine   > Faculty   > Details

Selected Publications

Sheline YI, West T, Yarasheski K, Swarm R, Jasielec MS, Fisher JR, Ficker WD, Yan P, Xiong Z, Frederikson C, Grzelak MV, Chott R, Bateman R, Morris, J, Mintun M, Lee J, Cirrito JR: An antidepressant decreases CSF Aβ production in healthy individuals and in transgenic AD mice. Science Translational Medicine 6: 236, 2014.

Sheline YI, Raichle ME : Resting state functional connectivity in preclinical Alzheimer's disease. Biological Psychiatry 5: 340-7, 2013.

Sheline YI, Disabato BM, Hranilovich J, Morris C, D’Angelo G, Pieper C, Tofanin T, Taylor WD, MacFall J, Wilkins C, Barch DM, Welsh-Bohmer KA, Steffens DC, Krishnan RR, Doraiswamy PM : Treatment course with antidepressant therapy in late-life depression. American Journal of Psychiatry 169(11): 1185-1193, 2013.

Sheline YI, Price JL, Yan Z, Mintun MA : Resting-state functional MRI in depression unmasks increased connectivity between networks via the dorsal nexus. Proceeding of the National Academy of Sciences USA 107: 111020-5, 2010.

Sheline YI, Raichle ME, Snyder AZ, Morris JC, Head D, Wang S, Mintun MA : Amyloid plaques disrupt resting state default mode network connectivity in cognitively normal elderly. Biological Psychiatry 67: 584-7, 2010.

Sheline YI, Pieper CF, Barch DM, Welsh-Boehmer K, McKinstry RC, MacFall JR, D’Angelo G, Garcia K, Gersing K, Wilkins C, Taylor W, Steffens DC, Krishnan RR, Doraiswamy PM : Support for the Vascular Depression Hypothesis in Late Life Depression: Results from a Two Site Prospective Antidepressant Treatment Trial. Archives of General Psychiatry 67: 277-85, 2010.

Sheline YI, Barch DM, Price JL, Rundle MM, Vaishnavi N, Snyder AZ, Mintun MA, Wang S, Coalson RS, Raichle ME : The Default Mode Network and Self-Referential Processes in Depression. Proceeding of the National Academy of Sciences 106: 1942-7, 2009.

Fales CL, Barch DM, Rundle MM, Mintun MA, Snyder AZ, Cohen JD, Mathews J, Sheline YI : Altered Emotional Interference Processing in Affective and Cognitive Control Brain Circuitry in Major Depression. Biological Psychiatry 63: 377-84, 2008.

Mintun MA, LaRossa GN, Sheline YI, Dence CS, Yoon Lee MS, Mach RH, Klunk WE, Mathis CA, DeKosky ST, Morris JC : PIB in a Nondemented Population Potential Antecedent Marker of Alzheimer Disease. Neurology. Neurology 67: 446-452, 2006.

Sheline YI, Barch DM, Garcia K, Gersing K, Pieper C, Welsh-Bohmer K, Steffens DC, Doraiswamy PM : Cognitive Function in Late Life Depression: Relationships to Depression Severity, Cerebrovascular Risk Factors and Processing Speed. Biological Psychiatry 60: 58-64, 2006.

Sheline YI, Gado MH, Kraemer HC : Untreated Depression and Hippocampal Volume Loss. American Journal of Psychiatry. American Journal of Psychiatry 160: 1516-1518, 2003.

Sheline YI : 3-D MRI Studies of Neuroanatomical Changes in Unipolar Major Depression: The Role of Stress and Medical Co-morbidity. Biological Psychiatry 48: 791-800, 2000.

Sheline YI, Wang PW, Gado MH, Csernansky JG, Vannier MW : Hippocampal Atrophy in Recurrent Major Depression. Proceedings of the National Academy of Sciences 93: 3908-3913, 1996.

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Last updated: 07/14/2014
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