About Us

We understand that no mood or anxiety illness is the same.

Our mission at the Center for Neuromodulation in Depression and Stress aims to leverage cutting edge neuroscience for personalized treatment. Since its founding in 2013, CNDS has consistently augmented and capitalized on the efforts of the outstanding neuroscience community at the University of Pennsylvania. We have been able to spur innovative research on the mechanisms underlying individual treatment responses across mood disorders, including depression, anxiety, bipolar disorder, and post-traumatic stress disorder (PTSD). Examined broadly, we determine how various treatments produce changes in brain activity and connectivity in order to improve treatment outcomes.

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CNDS Updates

  • Hello everyone! Wednesday, June 18, 2025

    Hello everyone! Our lab is currently recruiting adult research volunteers for an in-person study investigating the effects of transcranial magnetic stimulation (TMS) on bipolar depression. TMS is a non-invasive and personalized treatment that uses targeted magnetic pulses to stimulate the brain in specific areas. Study visits will take place on the University of Pennsylvania campus, and you will be compensated for your time and participation. For more information, please feel free to reach out to one of the contacts listed on the flyer or comment directly under this post. If you are interested, please fill out our screener at this link; the information that you provide, such as your medical history and demographics, is handled with strict confidentiality and adheres to all relevant data protection regulations, such as HIPAA.#bipolar #depression #upenn #researchstudy #clinicaltrials #transcranialmagneticstimulation (Feed generated with FetchRSS)

  • Voluntary medication supervision fails Tuesday, May 6, 2025

    Make sure to check out Dr. Sheline's new Substack: Voluntary medication supervision fails: Mandatory supervision was the only time he had been stable and it needed to be reinstated(Feed generated with FetchRSS)

  • Parent supervised medication Wednesday, April 30, 2025

    Make sure to check out Dr. Sheline's new Substack: Parent-supervised medication He now also needed oversight and help managing his apartment(Feed generated with FetchRSS)

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