Collaborators Department of Psychiatry
Lily Brown, Ph.D.
Assistant Professor of Psychology in Psychiatry Director at the Center for the Treatment and Study of Anxiety.
Dr. Brown received her Bachelors of Science Degree in Psychology at Drexel University and her Doctoral degree in Clinical Psychology and Learning and Behavior Psychology at the University of California, Los Angeles (UCLA). In graduate school, Dr. Brown researched mechanisms of change in fear conditioning and extinction, with a particular focus on posttraumatic stress disorder (PTSD), in the Anxiety and Depression Research Center. She completed her predoctoral internship at Brown University in the Psychosocial Research Department where she completed research on the rate of suicidal behaviors in patients with PTSD. Dr. Brown’s current research focuses on treatment development and implementation to mitigate suicide risk in patients with anxiety disorders and PTSD. She specializes in cognitive-behavior therapy for anxiety disorders, including Exposure and Response prevention (EX/RP) for obsessive compulsive disorder, and has been trained in the treatment of borderline personality disorder.
Ted Satterthwaite, M.D.
Associate Professor of Psychiatry
Ted is an Associate Professor in the Department of Psychiatry at the University of Pennsylvania Perelman School of Medicine. Ted completed medical and graduate training at Washington University in St. Louis, where he was a student of Randy L. Buckner. Subsequently, he was a psychiatry resident and a neuropsychiatry fellow at Penn, under the mentorship of Raquel E. Gur. He joined the faculty of the Department of Psychiatry in 2014, and has served as the Director of Imaging Analytics of the Brain Behavior Laboratory from 2015-2019. Since 2019, he has directed PennLINC. His research uses multi-modal neuroimaging to describe both normal and abnormal patterns of brain development, in order to better understand the origins of neuropsychiatric illness. He has been the PI of eight R01s from NIH. His work has been recognized with the Brain and Behavior Research Foundation's Klerman Prize for Clinical Research, the NIMH Biobehavioral Research Award for Innovative New Scientists (BRAINS) award, the NIH Merit Award, as well as several teaching awards.
Collaborators Department of Neurosurgery
H. Isaac Chen, MD
Assistant Professor of Neurosurgery at the Hospital of the University of Pennsylvania and the Veteran's Administration Medical Center
Dr. Chen's clinical interests include functional neurosurgery (i.e., deep brain stimulation and epilepsy surgery) and the resection of tumors in and around eloquent brain tissue. Dr. Chen is interested in developing novel approaches to brain repair, specifically with respect to the reconstruction of cortical circuitry. His laboratory combines techniques from neural tissue engineering, stem cell biology, and neural interface technologies to generate structured neural and axonal tissue for transplantation. In the in vivo setting, he studies the factors that promote neural tissue survival and integration and the functional effect of this tissue on large-scale neuronal networks. Additional research interests include translation of gene therapies and neuromodulatory treatments.
Casey Halpern, MD
Chief, Stereotactic and Functional Neurosurgery Associate Professor of Neurosurgery
Dr. Halpern researches human brain circuit mechanisms of mental health disease such as addiction, eating disorders and OCD as well as obesity, and uses his lab's innovations to develop targeted neuromodulatory interventions ranging from transcranial magnetic stimulation and deep bran stimulation to MR-guided focused ultrasound.
Collaborators Department of Pathology and Laboratory Medicine
Eline T. Luning Prak, M.D., Ph.D.
Professor of Pathology and Laboratory Medicine
Dr. Luning Prak’s lab studies lymphocyte repertoires by sequencing the DNA rearrangements that create antibodies and T cell receptors. These DNA rearrangements are diverse; hence, when sufficiently similar rearrangements are observed, they are likely to derive from cells that are clonally related. The lab is using these rich data sets to identify how lymphocytes participate in tissue-based immune responses in health and disease. In addition, Dr. Luning Prak directs the Human Immunology Core, which performs a variety of immune assays in support of translational research efforts on campus. She also helps to direct the Clinical Immunology lab at the Hospital of the University of Pennsylvania.
Collaborators Department of Neurology
H. Branch Coslett, M.D.
Professor of Neurology
He received his MD from the University of Pennsylvania School of Medicine in 1977, completed residency in Neurology at the University of Virginia in 1981, and a fellowship in Behavioral Neurology at the University of Florida in 1983. Dr. Coslett's research interest is in the area of Behavioral/Cognitive Neurology, and more specifically in understanding the architecture and neural bases for human cognition through the study of human spatial cognition, reading, semantic memory, functional imaging and transcranial magnetic stimulation.
Collaborators Department of Medicine
Carsten Skarke, M.D.
Adjunct Associate Professor of Medicine and the Robert L. McNeil Jr. Fellow in Translational Medicine and Therapeutics
Dr. Skarke is studying oscillatory functional networks in the human chronobiome under basal and perturbed conditions, the modulation of these oscillatory functional networks by sex and age and their deconsolidation by disease. Time-specific study paradigms integrate a broad array of multiomics, clinical and remote sensing outputs. These studies accomplish the time-specific deep phenotyping at unprecedented scale.
Collaborators Department of Biostatistics, Epidemiology and Informatics
Kristin Linn, Ph.D.
Assistant Professor of Biostatistics
Dr. Linn's methodological research program spans two broad areas: statistical methods for neuroimaging data and sequentially randomized clinical trials. As a co-investigator, she provides biostatistical leadership on projects in behavioral health economics, dermatology, implementation science, and psychology. Dr. Linn has experience designing sequential multiple assignment randomized trials (SMARTs) in a number of research areas. She is particularly interested in using data from SMART designs to estimate personalized dynamic interventions that improve long-term outcomes for individuals. Dr. Linn is actively working on statistical frameworks for harmonizing imaging data from multi-site studies and estimating spatially varying patterns of multimodal image associations. She is also interested in adapting methods from causal inference to address confounding in analyses of high-dimensional imaging data.
Russell (Taki) Shinohara, PHD
Assistant Professor of Biostatistics
Dr. Shinohara's methodological research spans several concentrations, including causal inference, survival analysis, imaging and large data sets, and general inference problems. He works on several CNDS projects and with the Oathes lab is working on analysis strategies to characterize brain network responses to TMS in fMRI recordings.
Haochang Shou, Ph.D.
Assistant Professor of Biostatistics
Dr. Shou’s methodological research mainly focuses on functional data analysis with complex structures. She is particularly interested in novel statistical modeling and estimation techniques for multimodal functional and longitudinal measurements, including neuroimaging and human activity data. Her collaborations span brain disorder studies, mental health, and biomarker evaluation for chronic kidney disease.
Collaborators Department of Radiology
Philip Cook, PHD
Senior Research Investigator
Dr Cook's primary research interests are in pipelines for multi-modal MRI studies of the brain. As a software developer, he contributes to Camino, ANTs and ANTsR, and PipeDream. His research uses these and other tools in studies of dementia, stress neurobiology and traumatic brain injury.
Christos Davatzikos, Ph.D.
Director, Center for Biomedical Image Computing and Analytics Affiliated Faculty, Penn Neurodegeneration Genomics Center Wallace T. Miller Sr. Professor of Radiology
Dr. Davatzikos holds a secondary appointment in Electrical and Systems Engineering at Penn as well as at the Bioengineering an Applied Mathematics graduate groups. He obtained his undergraduate degree by the National Technical University of Athens, Greece in 1989, and his Ph.D. degree from Johns Hopkins, in 1994, on a Fulbright scholarship. He then joined the faculty in Radiology and later in Computer Science, where he founded and directed the Neuroimaging Laboratory. In 2002 he moved to Penn, where he founded and directed the section of biomedical image analysis. Dr. Davatzikos’s interests are in medical image analysis. He oversees a diverse research program ranging from basic problems of imaging pattern analysis and machine learning, to a variety of clinical studies of aging and Alzheimer’s Disease, schizophrenia, brain cancer, and brain development. Dr. Davatzikos has served on a variety of scientific journal editorial boards and grant review committees. He is an IEEE fellow, and a fellow of the American Institute for Medical and Biological Engineering.
Yong Fan, Ph.D.
Associate Professor of Radiology
Dr. Fan has a broad background in medical image analysis and pattern recognition, with specific training in applied mathematics, statistics, and machine learning. His research interests are in the field of imaging analytics, machine learning, pattern recognition, and more generally in computational imaging. Much of his work has been focusing on methodology development and applications of machine learning techniques that quantify morphology and function from medical images, integrate multimodal information to aid diagnosis and prediction of clinical outcomes, and guide personalized treatments. The image analytic methods being and to be developed include functional connectomics, radiomics, image registration and segmentation, and personalized neuromodulatory therapies. On the clinical side, his primary focus is on applications in clinical neuroscience, in cancer, and in chronic kidney disease, aiming to develop precision diagnostic tools using machine learning and pattern recognition techniques. The clinical research studies include brain development, brain diseases such as Alzheimer's, schizophrenia, depression, and addiction, pediatric kidney diseases, and predictive modeling of treatment outcomes of cancer patients such as rectal and lung cancers.
Collaborators Department of Psychology
Joseph Kable, Ph.D.
Baird Term Professor
Joe Kable is the Baird Term Professor of Psychology and Marketing at the University of Pennsylvania and the Director of MindCORE, Penn’s hub for the integrative study of the mind. He studies the psychological and neural mechanisms of human decision making, using an integrated empirical approach that borrows from economics, the psychology of judgment and decision making, and social and cognitive neuroscience. He received his B.S. from Emory University in 1996 and his Ph.D. in Neuroscience from the University of Pennsylvania in 2004. He was a post-doctoral scholar at the Institute for the Interdisciplinary Study of Decision Making at NYU, before re-joining Penn in the Department of Psychology in 2008. He is a past recipient of the Early Career Award and a Past President of the Society for Neuroeconomics. His research is supported by the National Institute of Drug Abuse, the National Institute of Mental Health, the National Cancer Institute, and the National Science Foundation. He has given public talks at the Franklin Institute and Philadelphia Science Festival and his work has been featured in the New York Times, Washington Post, Newsweek, NBC News and Freakonomics.com.