Overview of Research
Our studies use neuroimaging examination of brain structure and function. We explore baseline brain characteristics to prove the relationship with patient symptoms of mood and anxiety. In addition, we investigate how brain function is changed by different treatment paradigms. For example, our studies examine:
- How individualized stimulation frequencies in transcranial magnetic stimulation (TMS) affects depressive symptoms in major depression and bipolar disorder
- How transdiagnostic dimensions of psychopathology (e.g. rumination, negative affect, anxious arousal) in anxious misery disorders (depression, anxiety, PTSD) relate to brain structure, resting state fMRI connectivity, task-evoked fMRI brain activity, and neuropsychological performance
- How computer-augmented cognitive behavioral therapy (CBT) produces changes in resting state fMRI connectivity and task-evoked fMRI brain activity that relate to treatment response
- How fMRI feedback conducted in real-time (cloud based/AI feedback) in the scanner can reduce negative attentional biases in depression
- How to optimize neuromodulation using psychopathology and neuroimaging
