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Roy Hoshi Hamilton, MD, MS, FAAN, FANA

Associate Professor of Neurology
Member, Center for Cognitive Neuroscience, University of Pennsylvania
Director, Laboratory for Cognition and Neural Stimulation, University of Pennsylvania
Member, Center for Neuroscience and Society, University of Pennsylvania
Assistant Dean of Diversity and Inclusion, Perelman School of Medicine, University of Pennsylvania
Director, Clinical Neurosciences Training Program (CNST), Perelman School of Medicine, University of Pennsylvania
Co-Director, Penn Minority Scholars in Aging Research Program, University of Pennsylvania
Vice Chair of Diversity and Inclusion, Department of Neurology, University of Pennsylvania
Department: Neurology

Contact information
Goddard Laboratories, Room 518
University of Pennsylvania
3710 Hamilton Walk
Philadelphia, PA 19104
Office: 215-573-7065
Fax: 215-898-1982
Graduate Group Affiliations
Education:
B.A. (Psychology, magna cum laude)
Harvard University, 1995.
M.S. (Health Sciences and Technology)
Massachusetts Institute of Technology , 2001.
M.D. (Medicine, cum laude)
Harvard Medical School, 2001.
Post-Graduate Training
Intern in Internal Medicine, University of California School of Medicine, Los Angeles, 2001-2002.
Resident in Neurology, University of Pennsylvania, 2002-2005.
Fellow in Cognitive Neurology, University of Pennsylvania, 2005-2007.
Certifications
American Board of Psychiatry and Neurology, 2006.
American Board of Psychiatry and Neurology, Maintenance of Certification (MOC), 2016.
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Description of Research Expertise

My research focus is on the characteristics and limits of functional neuroplasticity in the adult human brain. I investigate how the brain reorganizes itself in response to injury, and whether or not it is possible to enhance the brain’s potential for reorganization in order to speed rehabilitation using noninvasive electrical or magnetic brain stimulation. A second area of interest for me is on the use of noninvasive brain stimulation to elucidate and enhance mechanisms of cognition in healthy individuals, and the biological, social, and ethical implications of neural enhancement.

Description of Clinical Expertise

I principally treat patients suffering from dementia. I also have expertise in evaluating and treating patients with cognitive deficits following stroke.

Description of Other Expertise

I am deeply interested in medical education. I am heavily involved in medical student education in Neurology at the University of Pennsylvania School of Medicine, and I am the faculty director of the University of Pennsylvania School of Medicine Pipeline Program, multi-tiered neuroscience education program for inner-city high schools in Philadelphia.

Selected Publications

Irwin, D.J., McMillan, C.T., Xie, S.X., Rascovsky, K., Van Deerlin, V.M., Coslett, H.B., Hamilton, R., Aguirre, G., Lee, E.B., Lee, V.M.Y., Trojanowski, J.Q., Grossman, M.: Asymmetry of post-mortem neuropathology in behavioral-variant frontotemporal dementia Brain 141(1): 288-301, Jan 2018.

Harvey, D., Podell, J, Turkeltaub, P., Faseyitan, O, Coslett, H.B, Hamilton, R.H. : Variable bilateral neural network changes underlie sustained improvements in language following rTMS in chronic post-stroke aphasia. Cognitive and Behavioral Neurology 30(4): 133-144, Dec 2017.

McConathey, E.M., White, N.C., Gervits, F. Sherry Ash, S., Coslett, H.B., Grossman, M., Hamilton, R.H.: Baseline performance predicts tDCS-mediated improvements in language symptoms in primary progressive aphasia. Frontiers in Human Neuroscience 11(347), Jun 2017.

Hung, J., Bauer, A., Grossman, M., Hamilton, R.H., Coslett, H.B., Reilly, J.: Semantic feature training in combination with transcranial direct current stimulation (tDCS) for progressive anomia. Frontiers in Human Neuroscience 11(253): 1-12, May 2017.

Norise, C., Saccetti, D., Hamilton, R.H. : Transcranial direct durrent stimulation in post-stroke chronic aphasia: The impact of baseline severity and task specificity in a pilot sample. Frontiers in Human Neuroscience 11(260), May 2017.

Lee, Y.S., Zreik, J.T., Hamilton, R.H.: Patterns of neural activity predict picture-naming performance of a patient with chronic aphasia. Neuropsychologia 94: 52-60, Jan 2017.

Karuza, E.A., Balewski, Z.Z., Hamilton, R.H., Medaglia, Tardiff, N., Thompson-Schill, S.L.: Mapping the parameter space of tDCS and cognitive control via manipulation of current polarity and intensity. Frontiers in Human Neuroscience 10: 665, Dec 2016.

Meletath, S.K., Pavlick, D., Brennan, T., Hamilton, R., Chmielecki, J., Elvin, J.A., Palma, N., Ross, J.S., Miller, V.A., Stephens, P.J., Snipes, G., Rajaram, V., Ali, S.M., Melguizo-Gavilanes, I.: Personalized treatment for a patient with a BRAF V600E mutation using Dabrafenib and a tumor treatment fields device in a high-grade glioma arising from ganglioglioma. Journal of the National Comprehensive Cancer Network 14(11): 1345-50, Nov 2016.

Rosen, D.S., Erickson, B. Kim, Y.E. , Mirman, D., Hamilton, R.H., Kounios, J.: Anodal tDCS to right dorsolateral prefrontal cortex facilitates performance for novice jazz improvisers but hinders experts. Frontiers in Human Neuroscience 10: 579, Nov 2016.

Gervits, F., Ash, S., Coslett, H.B., Rascovsky, K., Grossman, M., Hamilton, R.: Transcranial direct current stimulation for the treatment of Primary Progressive Aphasia: an open-label pilot study. Brain and Language 162: 35-41, Nov 2016 Notes: Available online before print; doi: 10.1016/j.bandl.2016.05.007.

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Last updated: 04/08/2018
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