Penn Comprehensive Neuroscience Center

Faculty Members
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John Y.K. Lee, M.D.

Assistant Professor of Neurosurgery at the Pennsylvania Hospital
Attending Neurosurgeon, Hospital University of Pennsylvania, Philadelphia, PA
Attending Neurosurgeon, Pennsylvania Hospital, University of Pennsylvania, PA
Medical Director, Penn Gamma Knife at Pennsylvania Hospital
Attending Neurosurgeon, Children's Hospital of Philadelphia, Philadelphia PA
Unit Based Clinical Leadership - Physician Representative, Pennsylvania Hospital, Philadelphia PA
Department: Neurosurgery

Contact information
Department of Neurosurgery
Pennsylvania Hospital
Washington Square West Building
235 S. 8th Street
Philadelphia, PA 19106
Office: 215-829-5189
Fax: 215-829-6645
B.S. (Molecular Biophysics and Biochemistry)
Yale University, 1994.
Rutgers - Robert Wood Johnson Medical School, New Jersey, 1998.
M.S.C.E. (Clinical Epidemiology - candidate)
University of Pennsylvania, 2015.
Post-Graduate Training
Intern in Surgery, University of Pittsburgh, Pennsylvania, 1998-1999.
Resident in Neurological Surgery, University of Pittsburgh, Pennsylvania, 1999-2004.
Chief Resident in Neurological Surgery, University of Pittsburgh, Pennsylvania, 2004-2005.
Fellow (Functional Neurosurgery), Cleveland Clinic, Ohio , 2005-2006.
Gamma Knife Stereotactic Radiosurgery, University of Pittsburgh, 2005.
Board Certified, American Board of Neurological Surgery, 2009.
Cyberknife Stereotactic Radiosurgery, Accuray, 2011.
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Description of Clinical Expertise

Dr. Lee has a passion for minimally invasive ways to treat brain and skull base tumors. This passion is expressed as a commitment to endoscopic approaches to remove pituitary, clival, acoustic neuromas and other skull-base tumors. Another expression of his interest in minimally invasive methods is his devotion to stereotactic radiosurgery, eg. "incision-less" brain surgery.

In addition to brain tumors, Dr. Lee is committed to the comprehensive treatment of patients with craniofacial neuralgias, including trigeminal neuralgia, glossopharyngeal neuralgia, and hemifacial spasm. Dr. Lee uses minimally invasive, fully endoscopic surgical procedures including microvascular decompression (Jannetta procedure) and stereotactic radiosurgery to cure these disorders.

Selected Publications

Bohman LE, Pierce J, Stephen JH, Sandhu S, Lee JYK: Fully endoscopic microvascular decompression for trigeminal neuralgia: technique review and early outcomes. Neurosurgical Focus 37(4): E18, October 2014.

Ding D, Starke RM, Kano H, Nakaji P, Barnett GH, Mathieu D, Chiang V, Omay SB, Hess J, McBride HL, Honea N, Lee JY, Rahmathulla G, Evanoff WA, Alonso-Basanta M, Lunsford LD, Sheehan JP. : Gamma Knife Radiosurgery for Cerebellopontine Angle Meningiomas: A Multicenter Study. Neurosurgery 75(4): 398-408, Oct 2014.

Starke R, Kano H, Ding D, Nakaji P, Barnett GH, Mathieu D, Chiang V, Yu JB, Hess J, McBride HL, Honea N, Lee JY, Rahmathulla G, Evanoff WA, Alonso-Basanta M, Lunsford LD, Sheehan JP. : Stereotactic radiosurgery of petroclival meningiomas: a multicenter study. J Neurooncol 119(1): 169-76, Aug 2014.

Learned KO, Adappa ND, Lee JYK, Newman JG, Palmer JN, Loevner LA: MR imaging evolution of endoscopic cranial defect reconstructions using nasoseptal flaps and their distinction from neoplasm. American Journal of NeuroRadiology 35(6): 1182-9, June 2014.

Ojerholm E, Lee JY, Kolker J, Lustig R, Dorsey JF, Alonso-Basanta M. : Gamma Knife radiosurgery to four or more brain metastases in patients without prior intracranial radiation or surgery. Cancer Med 3(3): 565-71, Jun 2014.

Sheehan JP, Starke RM, Kano H, Kaufmann AM, Mathieu D, Zeiler FA, West M, Chao ST, Varma G, Chiang VL, Yu JB, McBride HL, Nakaji P, Youssef E, Honea N, Rush S, Kondziolka D, Lee JY, Bailey RL, Kunwar S, Petti P, Lunsford LD: Gamma Knife radiosurgery for sellar and parasellar meningiomas: a multicenter study. Journal of Neurosurgery 120(6): 1268-77, June 2014.

Lee JYK, Bohman L, Bergsneider M: Contemporary Neurosurgical Techniques for Pituitary Tumor Resection. J Neurooncology 117(3): 437-444, May 2014.

Learned KO, Mohan S, Hyder IZ, Bagley LJ, Wang S, Lee JYK: Imaging Features of a Gelatin-Thrombin Matrix Hemostatic Agent in the Intracranial Surgical Bed: A Unique Space-Occupying Pseudomass. American Journal of Neuroradiology 35(4): 686-90, April 2014.

Ali ZS, Bailey RL, Daniels LB, Vakhshori V, Lewis DJ, Hossain AT, Sitterley KY, Lee JY, Storm PB, Heuer GG, Stein SC: Comparative effectiveness of treatment options for pediatric craniopharyngiomas. J Neurosurg Pediatr 13(2): 178-88, Feb 2014.

Brastianos PK, Taylor-Weiner A, Manley PE, Jones RT, Dias-Santagata D, Thorner AR, Lawrence MS, Rodriguez FJ, Bernardo LA, Schubert L, Sunkavalli A, Shillingford N, Calicchio ML, Lidov HG, Taha H, Martinez-Lage M, Santi M, Storm PB, Lee JY, Palmer JN, Adappa ND, Scott RM, Dunn IF, Laws ER Jr, Stewart C, Ligon KL, Hoang MP, Van Hummelen P, Hahn WC, Louis DN, Resnick AC, Kieran MW, Getz G, Santagata S.: Exome sequencing identifies BRAF mutations in papillary craniopharyngiomas. Nature Genetics 46(2): 161-5, Feb 2014.

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Last updated: 12/19/2014
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