Stewart A Anderson

faculty photo
Associate Professor of Psychiatry
Department: Psychiatry
Graduate Group Affiliations

Contact information
3615 Civic Center Blvd.
Abramson Research Center
Room 517
Philadelphia, PA 19147
Education:
BA (Neuroscience )
Amherst College, 1984.
MD (Medicine)
University of Connecticut, 1989.
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Description of Clinical Expertise

I am a psychiatrist who worked mainly with treatment-resistant outpatients suffering from schizophrenia. Since moving in July, 2012 from Cornell Medical College to UPenn/The Children's Hospital of Philadelphia, I am not seeing patients as I focus on laboratory research into the causes of neuropsychiatric illnesses.

Description of Research Expertise

The focus of my laboratory concerns the molecular and cellular mechanisms that govern the development of the mammalian forebrain. We use mouse genetics, forebrain slice and dissociated culture techniques, as well as mouse and human pluripotent stem cells in cell culture and transplantation experiments to study the fate determination of interneurons of the cerebral cortex. We are particularly interested in understanding the molecular underpinnings behind the fate determination and axon targeting of subclasses of GABAergic interneurons implicated in the neuropathology of schizophrenia. In addition, we are exploring the use of mouse and human stem cell-derived interneurons in cell-based therapies for seizures, and as tools for the study of gene-gene and gene-environment interactions in neuropsychiatric disease, including schizophrenia and autism.

Selected Publications

Tyson JA, Goldberg EM, Maroof AM, Xu Q, Petros TJ, Anderson SA.: Duration of culture and Sonic Hedgehog signaling differentially specify PV versus SST cortical interneuron fates from embryonic stem cells. Development In Press., 2015.

Anderson SA, Parent JM (2015). : Reprogramming patient-derived cells to study the epilepsies. Nature Neuroscience In Press., 2015.

Gilani AI, Inan M, Chohan MO; Schobel SA, Chaudhury NH, Chuhma N, Glickstein S, MerkerR, Steinfeld S, Xu Q, Small SA, Anderson SA*, Ross ME*, Moore H*. *corresponding authors. : Interneuron precursor transplants into adult hippocampus reverse psychosis-relevant features in a mouse hippocampal disinhibition model PNAS 111(20): 7450-7455. 2014.

Lin H, Hsu FC, Baumann BH, Coulter DA, Anderson SA, Lynch DR: Cortical parvalbumin GABAergic deficits with α7 nicotinic acetylcholine receptor deletion: Implications for schizophrenia. Molecular and Cellular Neuroscience 61: 163-175, 2014.

Radonjic NV, Ayoub AE, Memi F, Yu X, Maroof A, Jakovcevski I, Anderson SA, Rakic P, Zecevic N.: Diversity of Cortical Interneurons in Primates: the Role of the Dorsal Proliferative Niche. Cell Reports 9(6): 2139-51, 2014.

Tyson JA, Anderson SA.: GABAergic Interneuron Transplants to Study Development and Treat Disease. Trends in Neurosciences 73 (3): 169-177, 2014.

Inan, M., Petros, T. J., Anderson, S. A.: Losing your inhibition: linking cortical GABAergic interneurons to schizophrenia. Neurobiol Dis 53: 36-48, 2013.

Petros, T. J., Maurer, C. W., Anderson, S. A.: Enhanced derivation of mouse ESC-derived cortical interneurons by expression of Nkx2.1. Stem Cell Res 11(1): 647-56, 2013.

Maroof, A. M., Keros, S., Tyson, J. A., Ying, S. W., Ganat, Y. M., Merkle, F. T., Liu, B., Goulburn, A., Stanley, E. G., Elefanty, A. G., Widmer, H. R., Eggan, K., Goldstein, P. A., Anderson, S. A., Studer, L.: Directed differentiation and functional maturation of cortical interneurons from human embryonic stem cells. Cell Stem Cell 12(5): 559-72, 2013.

Goulburn, A. L., Stanley, E. G., Elefanty, A. G., Anderson, S. A.: Generating GABAergic cerebral cortical interneurons from mouse and human embryonic stem cells. Stem Cell Res 8(3): 416-26, 2012.

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Last updated: 02/06/2015
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