Penn Lung Center

Faculty & Staff

faculty photo

Aili L. Lazaar, MD

Department: Medicine

Contact information
Penn-Presbyterian Medical Center
39th and Market Streets
PHI, 1st floor
Philadelphia, PA 19104-4318
Office: 215-662-8766
Fax: 215-243-5265
Education:
A.B. (Biochemistry)
Harvard University, 1982.
M.D. (Medicine)
New York University, 1986.
Post-Graduate Training
Intern, Internal Medicine, Boston City Hospital, Boston, MA, 1986-1987.
Resident, Internal Medicine, Boston City Hospital, Boston, MA, 1987-1989.
Research Registrar, Department of Medicine, Charing Cross Hospital, London, England, 1989-1990.
Pulmonary and Critical Care Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, 1990-1995.
Certifications
Board Certified, Internal Medicine, 1989.
Board Certified, Pulmonary Diseases, 1992.
Board Certified, Critical Care, 1993.
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Description of Research Expertise

Airway smooth muscle, matrix, VEGF, signal transduction

Description of Clinical Expertise

Asthma, COPD, COPD clinical trials

Selected Publications

Bloomer JC, Nash M, Webb A, Miller BE, Lazaar A, Beaumont C, Guiney WJ: Assessment of potential drug interactions by characterisation of human drug metabolism pathways using non-invasive bile sampling. British Journal of Clinical Pharmacology 75: 488-496, 2012.

Esther CR, Lazaar AL, Bordonali E, Qaqish B, Boucher RC: Elevated airway purines in chronic obstructive pulmonary disease. Chest 140: 954-960, 2011.

Lazaar AL, Sweeney LE, MacDonald AJ, Alexis NE, Chen C, Deans A, Tal-Singer R: SB-656933, a novel CXCR2 selective antagonist, inhibits ex-vivo neutrophil activation and ozone-induced airway inflammation in humans. British Journal of Clinical Pharmacology 72: 282-293, 2011.

Singh D, Petavy F, Macdonald AJ, Lazaar A and O`Connor BJ: The inhaled phosphodiesterase 4 inhibitor GSK256066 inhibits allergen challenge responses in asthma. Respiratory Research 11: 26, 2010.

Kim JH, Van Biesen C, Lazaar AL: VEGF alters tracheal ring force generation in a rho-dependent manner. Am J Respir Crit Care Med 169: A445, 2004.

Kazi AS, Lotfi S, Krymskaya VP, Lazaar AL. : Vascular endothelial growth factor (VEGF) up regulates fibronectin and matrix metalloproteinase-2 (MMP-2) secretion by human airway smooth muscle cells. Am J Respir Crit Care Med 167: A689, 2003.

Goncharova EA, Goncharov DA, Panettieri RA, Lazaar AL, Krymskaya VP. : VEGF stimulates proliferation and migration of LAM-derived cells. Am J Respir Crit Care Med 167: A953, 2003.

Kim JH, Ammit AJ, Puré E, Lazaar AL. : Hyaluronan activates NF-kB and induces IL-6 by human airway smooth muscle cells. Am J Respir Crit Care Med 167: A690, 2003.

Lazaar AL, Panettieri RA: Airway Smooth Muscle: An Immunomodulatory Cell? Therapeutic Targets in Airway Inflammation. Eissa NT, Huston DP (eds.). Marcel Dekker, Inc., New York 177: 767-780, 2003.

Lazaar, A L. Albelda, S M. Pilewski, J M. Brennan, B. Pure, E. Panettieri, R A Jr.: T lymphocytes adhere to airway smooth muscle cells via integrins and CD44 and induce smooth muscle cell DNA synthesis. Journal of Experimental Medicine 180(3): 807-16, Sep 1 1994.

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Last updated: 01/27/2013
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