Aili L. Lazaar - Faculty Biosketch

Aili L. Lazaar, MD

Adjunct Associate Professor of Medicine (Pulmonary, Allergy and Critical Care)

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Department: Medicine

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46 Contact information
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Penn Medicine University City
1a 3737 Market Street
32 10th floor
Philadelphia, PA 19104-4318

2e Office: 215-662-8766
32 Fax: 215-243-5265
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13 Education:
21 9 A.B. 19 (Biochemistry) c
2b Harvard University, 1982.
21 9 M.D. 15 (Medicine) c
2c New York University, 1986.
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1f Post-Graduate Training
24 59 Intern, Internal Medicine, Boston City Hospital, Boston, MA, 1986-1987.
24 5b Resident, Internal Medicine, Boston City Hospital, Boston, MA, 1987-1989.
24 71 Research Registrar, Department of Medicine, Charing Cross Hospital, London, England, 1989-1990.
24 80 Pulmonary and Critical Care Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, 1990-1995.
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17 Certifications
28 3b Board Certified, Internal Medicine, 1989.
28 3c Board Certified, Pulmonary Diseases, 2012.
28 37 Board Certified, Critical Care, 2013.
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3 90 Permanent link
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b6 > Perelman School of Medicine > Faculty > Details a

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Description of Research Expertise

82 Phase I-II clinical trials (COPD, critical care, pulmonary hypertension, respiratory viral infection, Hepatitis B)
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Description of Clinical Expertise

32 Asthma, COPD, COPD clinical trials
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Selected Publications

e0 Esther CR, Lazaar AL, Bordonali E, Qaqish B, Boucher RC: Elevated airway purines in chronic obstructive pulmonary disease. Chest 140(4): 954-960, 2011.

15d Lazaar AL, Sweeney LE, MacDonald AJ, Alexis NE, Chen C, Deans A, Tal-Singer R: SB-656933, a novel CXCR2 selective antagonist, inhibits ex-vivo neutrophil activation and ozone-induced airway inflammation in humans. British Journal of Clinical Pharmacology 72(2): 282-293, 2011.

10e Singh D, Petavy F, Macdonald AJ, Lazaar A and O`Connor BJ: The inhaled phosphodiesterase 4 inhibitor GSK256066 inhibits allergen challenge responses in asthma. Respiratory Research 11(1): 26, 2010.

db Kim JH, Van Biesen C, Lazaar AL: VEGF alters tracheal ring force generation in a rho-dependent manner. Am J Respir Crit Care Med 169: A445, 2004.

13b Kazi AS, Lotfi S, Krymskaya VP, Lazaar AL. : Vascular endothelial growth factor (VEGF) up regulates fibronectin and matrix metalloproteinase-2 (MMP-2) secretion by human airway smooth muscle cells. Am J Respir Crit Care Med 167: A689, 2003.

fe Goncharova EA, Goncharov DA, Panettieri RA, Lazaar AL, Krymskaya VP. : VEGF stimulates proliferation and migration of LAM-derived cells. Am J Respir Crit Care Med 167: A953, 2003.

ee Kim JH, Ammit AJ, Puré E, Lazaar AL. : Hyaluronan activates NF-kB and induces IL-6 by human airway smooth muscle cells. Am J Respir Crit Care Med 167: A690, 2003.

10d Lazaar AL, Panettieri RA: Airway Smooth Muscle: An Immunomodulatory Cell? Therapeutic Targets in Airway Inflammation. Eissa NT, Huston DP (eds.). Marcel Dekker, Inc., New York 177: 767-780, 2003.

146 Lazaar AL, Albelda SM, Pilewski JM, Brennan B, Pure E, Panettieri RA Jr.: T lymphocytes adhere to airway smooth muscle cells via integrins and CD44 and induce smooth muscle cell DNA synthesis. Journal of Experimental Medicine 180(3): 807-16, Sep 1 1994.

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26 Last updated: 12/22/2022
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