Penn Lung Center

Faculty & Staff

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Reynold A. Panettieri, Jr., MD

Robert L. Mayock and David A. Cooper Professor of Pulmonary Medicine
Director, Comprehensive Asthma Program, University of Pennsylvania Health System
Chief, Asthma Section, Pulmonary, Allergy & Critical Care Division, University of Pennsylvania
Director, Airways Biology Initiative, University of Pennsylvania
Associate Program Director, General Clinical Research Program, University of Pennsylvania
Director, Integrative Health Sciences Facilty Core, Center of Excellence in Environmental Toxicology, University of Pennsylvania
Deputy Director, Center of Excellence in Environmental Toxicology, University of Pennsylvania
Department: Medicine

Contact information
University of Pennsylvania
125 South 31st Street
TRL Suite 1200
Philadelphia, PA 19104-3413
Office: (215) 573-9860
Fax: (215) 746-1224
Lab: (215) 746-2759
Graduate Group Affiliations
Education:
B.S. (Biology)
St. Joseph's University, Philadelphia, PA, 1979.
M.D. (Medicine)
University of Pennsylvania, 1983.
M.A. (Honorary)
University of Pennsylvania, 1998.
Post-Graduate Training
Intern in Medicine, Hospital of the University of Pennsylvania , 1983-1984.
Resident in Medicine , Hospital of the University of Pennsylvania, 1984-1986.
Fellowship, Pulmonary Diseases, Hospital of the University of Pennsylvania, 1986-1989.
Research Fellowship (Supervisors: Drs. Alan Kelly and Neal Rubinstein) , University of Pennsylvania, 1987-1989.
Research Fellowship (Supervisor: Dr. Peter Nowell) , University of Pennsylvania, 1988-1989.
Certifications
Internal Medicine, 1986.
Pulmonary Medicine, 1988.
Critical Care Medicine, 1992.
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Description of Research Expertise

Smooth muscle biology, airway remodeling, respiratory pharmacology and physiology

Description of Clinical Expertise

Asthma, chronic obstructive pulmonary disease, irreversible airway obstruction

Selected Publications

Morgan Sarah J, Deshpande Deepak A, Tiegs Brian C, Misior Anna M, Yan Huandong, Hershfeld Alena V, Rich Thomas C, Panettieri Reynold A, An Steven S, Penn Raymond B: Beta-agonist-mediated relaxation of airway smooth muscle is PKA-dependent. The Journal of biological chemistry Page: Epub ahead of print, Jun 2014.

Himes Blanca E, Jiang Xiaofeng, Wagner Peter, Hu Ruoxi, Wang Qiyu, Klanderman Barbara, Whitaker Reid M, Duan Qingling, Lasky-Su Jessica, Nikolos Christina, Jester William, Johnson Martin, Panettieri Reynold A, Tantisira Kelan G, Weiss Scott T, Lu Quan: RNA-Seq Transcriptome Profiling Identifies CRISPLD2 as a Glucocorticoid Responsive Gene that Modulates Cytokine Function in Airway Smooth Muscle Cells. PloS one 9(6): e99625, June 2014.

Hu Ruoxi, Pan Wenchi, Fedulov Alexey V, Jester William, Jones Matthew R, Weiss Scott T, Panettieri Reynold A, Tantisira Kelan, Lu Quan: MicroRNA-10a controls airway smooth muscle cell proliferation via direct targeting of the PI3 kinase pathway. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 28(5): 2347-2357, May 2014.

Ge MQ, Kolupoti A, Kokalari B, Redai IG, Kemeny DM, Bailey M, Sheridan JS, Panettieri RA Jr, Penn RB, Haczku A: Lorazepam treatment reversed pulmonary inflammation in a murine model of allergic exacerbation induced by chronic social stress American journal of respiratory and critical care medicine 189: A4225, May 2014.

Pluznick JL, Yoon A-R, Natarajan N, Aisenberg W, De Santiago B, Huang J, Panettieri RA Jr, Liggett SB, An SS: Functional expression of the olfactory signaling system in human airway smooth muscle. American journal of respiratory and critical care medicine 189: A6662, May 2014.

Yoo E, Koziol-White CJ, Jude JA, Panettieri RA Jr : Elevated rho kinase activity mediates intrinsic hypercontractility in airway smooth muscle from fatal asthmatic subjects. American journal of respiratory and critical care medicine 189: A2683, May 2014.

Jude JA, Koziol-White CJ, Cooper P, Jester W, Jia Y, Correll C, Mehmet H, Panettieri RA Jr : Ozone induces airway hyperresponsiveness but decreases cytokine secretion in precision-cut human lung slices. American journal of respiratory and critical care medicine 189: A1689, May 2014.

Jude JA, Koziol-White CJ, Scala J, Ouyang Y, Jester W, Maute C, Dalton P, Panettieri RA Jr: Formaldehyde exposure induces anti-oxidant response in human airway smooth muscle (HASM) cells. American journal of respiratory and critical care medicine 189: A5313, May 2014.

Koziol-White CJ, Strong P, Ito K, Rapeport G, Gern JE, Panettieri RA Jr : Rhinovirus 16 (RV16) induced mediator release, but not airway hyper-responsiveness, from human small airways is modulated by the narrow spectrum kinase inhibitor RV1088. American journal of respiratory and critical care medicine 189: A3532, May 2014.

Koziol-White CJ, Zhao HJ, Vakkalanka S, Panettieri RA Jr: The novel PI3Kdelta/gammma inhibitor, RP6503, differentially modulates mediator release from human precision cut lung slices (hPCLS) and human airway smooth muscle (hASM) in response to TNF╬▒ and IFNgamma stimulation. American journal of respiratory and critical care medicine 189: A5319, May 2014.

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Last updated: 07/25/2014
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