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Michael G.S. Shashaty, MD, MSCE

Assistant Professor of Medicine at the Hospital of the University of Pennsylvania
Associate Scholar, Center for Clinical Epidemiology and Biostatistics
Rapid Response Medical Director, Hospital of the University of Pennsylvania
Department: Medicine

Contact information
5036 W Gates
Hospital of the University of Pennsylvania
3400 Spruce Street
Philadelphia, PA 19104
Office: 215-615-5031
BS (Biology)
Georgetown University, 1997.
MD (Medicine)
Vanderbilt University School of Medicine, 2003.
MSCE (Clinical Epidemiology)
Perelman School of Medicine, University of Pennsylvania, 2010.
Post-Graduate Training
Intern, Internal Medicine, Hospital of the University of Pennsylvania, 2003-2004.
Resident, Internal Medicine, Hospital of the University of Pennsylvania, 2004-2006.
Fellow, Pulmonary and Critical Care Medicine, Hospital of the University of Pennsylvania, 2007-2010.
Internal Medicine, American Board of Internal Medicine, 2006.
Pulmonary Diseases, American Board of Medical Specialties, 2010.
Critical Care Medicine, American Board of Medical Specialties, 2012.
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Description of Research Expertise

Dr. Shashaty's career is focused on epidemiologic and translational research studies of the risks for and mechanisms of acute organ dysfunction, primarily acute kidney injury (AKI), in critical illness populations.

Dr. Shashaty’s studies are mostly focused on critically ill trauma, sepsis, and lung transplant patients. He is the principal investigator of Penn’s cohort study of acute organ dysfunction after trauma. In this population he has studied clinical, molecular, and genetic risk factors for AKI. Current studies include 1) adipokines and inflammatory mediators as mechanisms underlying the association of obesity and AKI, the subject of his K23 Mentored Career Development Award and 2) programmed necrosis as a mechanism of cell death in AKI, supported by a McCabe Fund Pilot Award and a pilot award from the Penn Acute Research Collaboration.

Dr. Shashaty is also the principal investigator of the Lung Transplant Outcomes Group - Acute Kidney Injury (LTOG-AKI) study, a multicenter R01-funded study of the clinical epidemiology of AKI, molecular markers of AKI, and AKI prediction after lung transplantation. Pilot studies in this population were previously supported by a Penn University Research Foundation Award, and LTOG-AKI utilizes the infrastructure of the R01-funded Lung Transplant Outcomes Group (Dr. Jason Christie, PI) which was created in 2002 to study the epidemiology of primary graft dysfunction.

Dr. Shashaty collaborates in multiple other research efforts at Penn. In trauma, he is a co-investigator for a Department of Defense Grant (Dr. Nilam Mangalmurti, PI) to study molecular markers of necroptosis as mediators of transfusion-associated acute respiratory distress syndrome. He also works with Dr. Nuala Meyer to manage the division’s Molecular Epidemiology of Severe Sepsis in the ICU (MESSI) cohort, in which he spearheads both epidemiologic and molecular studies of AKI risk. He partners with other critical care researchers on studies of ARDS, delirium and cognitive dysfunction, and frailty in both sepsis and trauma populations. He also collaborates with translational and epidemiologic investigators in the Renal, Electrolyte, and Hypertension Division to study mechanisms, early identification, and outcomes of AKI.

Description of Clinical Expertise

Dr. Shashaty is specialty-trained in internal medicine, pulmonary diseases, and critical care medicine. He is an attending physician at the Hospital of the University of Pennsylvania (HUP), with the majority of his clinical time spent in the medical intensive care unit. He also attends on the Critical Care Outreach and Procedure Service (CCOPS) and at the Good Shepherd Penn Partners Long Term Acute Care Hospital (LTACH).

Dr. Shashaty is currently the Rapid Response Medical Director at HUP. In this capacity, he works with a multidisciplinary team to provide oversight, design and conduct training, and pursue quality improvement initiatives in the areas of clinical emergencies and management of cardiac arrest.

Dr. Shashaty is actively engaged in teaching fellows, house officers, medical students, and advanced practice providers through both HUP clinical services, classes at the Perelman School of Medicine, and training programs at the Penn School of Nursing.
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Last updated: 02/07/2018
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