Dr. Shashaty's career is focused on epidemiologic and translational research studies of the risks for and mechanisms of acute organ dysfunction, primarily acute kidney injury (AKI), in critical illness populations.
The majority of Dr. Shashaty’s studies involve critically ill trauma and sepsis patients. In collaboration with his research mentor, Dr. Jason Christie, he is the primary manager of Penn’s cohort study of acute organ dysfunction after trauma. In this population he has studied clinical, molecular, and genetic risk factors for AKI. The bulk of his current studies involve the elucidation of mechanisms underlying the association of obesity with AKI in human subjects. Using molecular studies and novel imaging techniques, he is investigating the potential contribution of visceral and subcutaneous adipose tissue-sourced adipokines and inflammatory mediators to the obesity-AKI association. These projects are being done in collaboration with Dr. Muredach Reilly (Penn Cardiovascular Institute) and Dr. Jayaram Udupa (Department of Radiology). Dr. Shashaty is supported in these endeavors as the PI of an NIH K23 Mentored Career Development Award.
Dr. Shashaty is involved in multiple other research efforts at Penn. He is the lead investigator on projects focused on the genetic underpinnings of the association of African American race with AKI after trauma. He also works with Dr. Nuala Meyer to manage the division’s Molecular Epidemiology of Severe Sepsis in the ICU (MESSI) cohort, in which he spearheads both epidemiologic and molecular studies of AKI risk. He partners with other critical care researchers on studies of Acute Respiratory Distress Syndrome (ARDS) risk after trauma. He also has active collaborations with both basic and epidemiologic investigators in the Renal, Electrolyte, and Hypertension Division to study mechanisms, early identification, and outcomes of AKI.
Dr. Shashaty is specialty-trained in internal medicine, pulmonary diseases, and critical care medicine. He is an attending physician at the Hospital of the University of Pennsylvania (HUP), with the majority of his clinical time spent in the medical intensive care unit. He also attends on the Procedure And Resuscitation Service (PARS) and at the Good Shepherd Penn Partners Long Term Acute Care Hospital (LTACH). He is actively engaged in teaching fellows, house officers, and medical students through both HUP clinical services and classes at the Perelman School of Medicine.
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Last updated: 02/05/2016
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