Dr. Mangalmurti serves as an attending physician for the Medical Intensive Care Unit and the Procedure and Resuscitation Service at the Hospital of the University of Pennsylvania. Dr. Mangalmurti’s clinical interests include acute lung injury and the management of the critically ill patient.
Dr. Mangalmurti’s research interests include lung inflammation, erythrocyte-endothelial interactions and the role of red cell transfusions in altering the lung inflammatory response to injury. She is interested in how the formation of novel red cell antigens during erythrocyte storage can alter cell-cell interactions and augment lung injury in vivo. The primary focus of the lab has been examining the role of the Receptor for Advanced Glycation End-Products (RAGE),a multi-ligand receptor that is highly expressed in the lung and may perpetuate lung inflammation following transfusion. Dr. Mangalmurti’s research seeks to advance our understanding of how the red cell “storage lesion” may adversely affect susceptible transfusion recipients.
Shashaty MGS, Reilly JP, Sims C, Holena DN, Qing D, Meyer NJ, Lanken PN, Feldman HI, Christie JD, Mangalmurti NS
: Plasma levels of receptor interacting protein kinase-3 (RIP3), an essential mediator of necroptosis, are associated with acute kidney injury in critically ill trauma patients. Shock 2016.
Qing D,Conegliano D, Shashaty MG, Seo J, Reilly JP, Worthen GS, Huh D, Meyer NJ, Mangalmurti NS.: RBCs Induce Necroptosis of Lung Endothelial Cells and Increase Susceptibility to Lung Inflammation. American Journal of Respiratory and Critical Care Medicine 190(11): 1243-54, December 2014.
Mangalmurti NS, Friedman JL, Wang LC, Stolz DB, Muthukumaran G, Siegel DL, Schmidt AM, Lee JS, Albelda SM: The Receptor for Advanced Glycation End Products Mediates Lung Endothelial Activation by RBCs. Am J Physiol Lung Cell Mol Physiol 304(4): 250-63, February 2013.
Mangalmurti Nilam S, Chatterjee Shampa, Cheng Guanjun, Andersen Emily, Mohammed Aishat, Siegel Donald L, Schmidt Ann Marie, Albelda Steven M, Lee Janet S: Advanced glycation end products on stored red blood cells increase endothelial reactive oxygen species generation through interaction with receptor for advanced glycation end products. Transfusion 50(11): 2353-61, Nov 2010.
Mangalmurti Nilam S, Xiong Zeyu, Hulver Mei, Ranganathan Mrunalini, Liu Xiang Hong, Oriss Timothy, Fitzpatrick Meghan, Rubin Marc, Triulzi Darrell, Choi Augustine, Lee Janet S: Loss of red cell chemokine scavenging promotes transfusion-related lung inflammation. Blood 113(5): 1158-66, Jan 2009.
Christie JD, Shah CV, Kawut SM, Mangalmurti N, Lederer DJ, Sonett JR,
Ahya VN, Palmer SM, Wille K, Lama V, Shah PD, Shah A, Weinacker A,
Deutschman CS, Kohl BA, Demissie E, Bellamy S, Ware LB.: Plasma Levels of Receptor for Advanced Glycation End-Products (sRAGE), Blood Transfusion, and Risk Of Primary Graft Dysfunction. American Journal of Respiratory and Critical Care Medicine. 180(10): 1010-1015, 2009.
Yani Zhao, Nilam Mangalmurti, Zeyu Xiong, Bharat Prakash, Fengli Guo, Donna B. Stolz, and Janet S. Lee: DARC-mediated CXCL1 endocytosis is caveolin-1 independent and occurs through a macropinocytosis-like process in endothelial cells. Plos One 6(12), December 2011.
Reilly JP, Anderson BJ, Mangalmurti NS, Nguyen TD, Holena DN, Wu Q, Nguyen ET, Reilly MP, Lanken PN, Christie JD, Meyer NJ, Shashaty MGS: The ABO histo-blood group and acute kidney injury in critically ill trauma and sepsis patients. Clinical Journal of the American Society of Nephrology. September 2015
Shah RJ, Bellamy SL, Lee JC, Cantu E, Diamond JM, Mangalmurti N, Kawut, SM, Ware LB, Christie JD: Early plasma soluble Receptor for Advanced Glycation End Product levels are associated with bronchiolitis obliterans syndrome. American Journal of Transplantation 13(3): 754-9, March 2013.
Zhao Y, Xiong Z, Lechner EJ, Klenotic PA, Hamburg BJ, Hulver M, Khare A, Oriss T, Mangalmurti N, Chan Y, Zhang Y, Ross MA, Stolz DB, Rosengart MR, Pilewski J, Ray P, Ray A, Silverstein RL, Lee JS: Thrombospondin-1 triggers macrophage IL-10 production and promotes resolution of experimental lung injury. Mucosal Immunology September 2013.
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Last updated: 09/16/2016
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