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Nilam S. Mangalmurti, MD

Assistant Professor of Medicine at the Hospital of the University of Pennsylvania
Attending Physician, Hospital of University of Pennsylvania
Department: Medicine

Contact information
Stemmler Hall
3450 Hamilton Walk
Philadelphia, PA 19104
Office: 2155739918
Fax: 2155734469
BA (Biology and South Asian Studies)
University of Pennsylvania, 1998.
MD (Medicine)
Temple University School of Medicine, 2002.
Post-Graduate Training
Intern - Internal Medicine, NYU Langone Medical Center, New York, NY, 2002-2003.
Fellowship/Residency - Internal Medicine, NYU Langone Medical Center, New York, NY, 2003-2005.
Fellowship - Pulmonary/Critical Care Medicine, University of Pittsburgh Medical Center, 2005-2008.
Postdoctoral Fellowship - Pulmonary/Critical Care Medicine, University of Pennsylvania, 2008-2010.
Diplomate, American Board of Internal Medicine, 2005.
Diplomate, Pulmonary Medicine, 2008 (initial certification), 2018.
Diplomate, Critical Care Medicine, 2009 (initial certification), 2019.
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Description of Clinical Expertise

Dr. Mangalmurti serves as an attending physician for the Medical Intensive Care Unit and the Procedure and Resuscitation Service at the Hospital of the University of Pennsylvania. Dr. Mangalmurti’s clinical interests include acute lung injury and the management of the critically ill patient.

Description of Research Expertise

My research interests stem from my clinical interest in sepsis and lung injury. Our lab investigates how red blood cells and lung endothelium modulate innate immune responses. Our current research aims to understand the mechanisms of the programmed cell death pathway necroptosis in lung endothelium and the role of danger signals released during necroptosis in the development of lung injury. We have also focused on defining the immunomodulatory properties of RBCs and their role in the development of lung injury. Our lab utilizes murine models, human cell culture models, patient samples and dynamic microfluidic models of RBC-induced endothelial injury in order to understand how perturbations of normal RBC and endothelial function contribute to lung inflammation and injury.

Selected Publications

Nilam Mangalmurti and Christopher A. Hunter: Cytokine Storms: Understanding COVID-19. Immunity 53(1): 19-25, July 2020 Notes:

H. Luke Anderson, Igor E. Brodsky, Nilam S. Mangalmurti: The evolving erythrocyte: RBCs as modulators of innate immunity. Journal of Immunology 201(5): 1343-1351, September 2018.

Meghan J. Hotz, Danielle Qing, Michael G. S. Shashaty, Peggy Zhang, Hilary Faust, Neal Sondheimer, Stefano Rivella, G. Scott Worthen, and Nilam S. Mangalmurti : Red Blood Cells Homeostatically Bind Mitochondrial DNA through TLR9 to Maintain Quiescence and to Prevent Lung Injury. American Journal of Respiratory and Critical Care Medicine 197(4): 470-480, February 2018.

Hilary Faust, Metthew LK Lam, Danielle Qing, Nilam S. Mangalmurti: RAGE Interacts with the Necroptotic Protein RIPK3 and Mediates Transfusion-Induced Danger Signal Release Vox Sanguinis 115(8), November 2020.

Michael G. S. Shashaty, MD, MSCE; John P. Reilly, M.D., M.S.C.E.; Hilary E. Faust, M.D.; Caitlin M. Forker, B.A.; Caroline A. G. Ittner, Ph.D.; Peggy X. Zhang, B.S.; Meghan J. Hotz, B.S.; David Fitzgerald; Wei Yang, Ph.D.; Brian J. Anderson, M.D., M.S.C.E.; Daniel N. Holena, MD, MSCE; Paul N. Lanken, M.D., M.S.C.E.; Jason D. Christie, M.D., M.S.C.E.; Nuala J. Meyer, MD, MS; Nilam S. Mangalmurti, M.D.: Plasma receptor interacting protein kinase-3 levels are associated with acute respiratory distress syndrome in sepsis and trauma: a cohort study. Critical Care 23(1), June 2019.

Jeongyun Seo1, David Conegliano1, Megan Farrell, Minseon Cho, Xueting Ding, Thomas Seykora, Danielle Qing, Nilam S. Mangalmurti, Dongeun Huh : A microengineered model of RBC transfusion-induced pulmonary vascular injury. Scientific Reports 7(1): 3413, June 2017.

Qing D,Conegliano D, Shashaty MG, Seo J, Reilly JP, Worthen GS, Huh D, Meyer NJ, Mangalmurti NS.: Red Blood Cells Induce Necroptosis of Lung Endothelial Cells and Increase Susceptibility to Lung Inflammation. American Journal of Respiratory and Critical Care Medicine 190(11): 1243-54, December 2014.

Faust HE, Reilly JP, Anderson BJ, Ittner CAG, Forker CM, Zhang P, Weaver BA, Holena DN, Lanken PN, Christie JD, Meyer NJ, Mangalmurti NS, Shashaty MGS: Plasma Mitochondrial DNA Levels Are Associated With ARDS in Trauma and Sepsis Patients. Chest 157(1): 67-76, January 2020.

Mangalmurti NS, Friedman JL, Wang LC, Stolz DB, Muthukumaran G, Siegel DL, Schmidt AM, Lee JS, Albelda SM: The Receptor for Advanced Glycation End Products Mediates Lung Endothelial Activation by RBCs. Am J Physiol Lung Cell Mol Physiol 304(4): L250-63, February 2013.

Mangalmurti Nilam S, Xiong Zeyu, Hulver Mei, Ranganathan Mrunalini, Liu Xiang Hong, Oriss Timothy, Fitzpatrick Meghan, Rubin Marc, Triulzi Darrell, Choi Augustine, Lee Janet S: Loss of red cell chemokine scavenging promotes transfusion-related lung inflammation. Blood 113(5): 1158-66, Jan 2009.

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Last updated: 07/21/2021
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