My research is focused on translational studies of clinical and genetic risk factors for Primary Graft Dysfunction (PGD) and chronic rejection after lung transplantation. In addition to increased perioperative mortality, patients recovering from severe PGD have decreased quality of life and an increase risk of chronic rejection, the leading obstacle to long term survival after lung transplantation. Therefore, studies of the mechanisms of PGD and BOS will have a significant impact on the field of lung transplantation and may lead to therapies that improve the overall survival of lung transplant recipients. My current primary research interest is evaluating the role of innate immune activation in the development of post-lung transplant PGD and chronic rejection. I am also actively involved in integrating data on differential innate immune activation with the expanding body of knowledge on microbial colonization and infection of the lower respiratory tract as part of our evaluation of the microbiome of lung transplant recipients
My clinical practice is focused on Advanced Lung Disease and Lung Transplantation. My outpatient practice is at the Penn Lung Center and is predominantly composed of patients before and after lung transplantation. I also have a significant role in Critical Care Medicine, with a primary practice in the Medical Intensive Care Unit at the Hospital of the University of Pennsylvania. Additionally, my practice includes attending on the Procedure and Rapid Response service at the Hospital of the University of Pennsylvania, as well as at the Long Term Acute Care Hospital, at Good Shepard Penn Partners.
Abbas A A, Diamond J M, Chehoud C, Chang B, Kotzin J J, Young J C, Imai I, Haas A R, Cantu E, Lederer D J, Meyer K, Milewski R K, Olthoff K M, Shaked A, Christie J D, Bushman F D, Collman R G: The Perioperative Lung Transplant Virome: Torque Teno Viruses are Elevated in Donor Lungs and Show Divergent Dynamics In Primary Graft Dysfunction. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons Oct 2016.
Diamond Joshua M, Arcasoy Selim, McDonnough Jamiela A, Sonett Joshua R, Bacchetta Matthew, D'Ovidio Frank, Cantu Edward, Bermudez Christian A, McBurnie Amika, Rushefski Melanie, Kalman Laurel H, Oyster Michelle, D'Errico Carly, Suzuki Yoshikazu, Giles Jon T, Ferrante Anthony, Lippel Matthew, Singh Gopal, Lederer David J, Christie Jason D: Adipose Gene Expression Profile Changes with Lung Allograft Reperfusion. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons Jul 2016 Notes: Poster presentation.
Monticelli Laurel A, Buck Michael D, Flamar Anne-Laure, Saenz Steven A, Tait Wojno Elia D, Yudanin Naomi A, Osborne Lisa C, Hepworth Matthew R, Tran Sara V, Rodewald Hans-Reimer, Shah Hardik, Cross Justin R, Diamond Joshua M, Cantu Edward, Christie Jason D, Pearce Erika L, Artis David: Arginase 1 is an innate lymphoid-cell-intrinsic metabolic checkpoint controlling type 2 inflammation. Nature immunology 17(6): 656-65, Jun 2016.
Purnema Madahar, Jonathan P. Singer, Jessica Sell, Patricia Katz, Jeffrey A. Golden, Hilary Y. Robbins, Lori Shah, Kashif Raza, Jaime Hook, Matthew Bacchetta, Frank D'Ovidio, Joshua R. Sonett, Jasleen Kukreja, Lorriana Leard, Steven Hays, Selim Arcasoy, Joshua M. Diamond, Jason D. Christie, David J. Lederer: Body Composition Phenotypes in Adults Awaiting Lung Transplantation. American Journal of Respiratory and Critical Care Medicine 193: A4664, May 2016 Notes: Poster presentation.
Joshua M. Diamond, Selim Arcasoy, Jamiela McDonnough, Edward Cantu, Joshua R. Sonett, Matthew Bacchetta, Frank D'Ovidio, Christian A. Bermudez, Amika McBurnie, Melanie Rushefski, Yoshikazu Suzuki, Jon Giles, Michelle Oyster, Carly D'Errico, Anthony Ferrante, Matthrw Lippel, Gopal Singh, Jason D. Christie, David J. Lederer: Adipose Gene Expression Profile Changes with Lung Allograft Reperfusion. American Journal of Respiratory and Critical Care Medicine 193: A4680, May 2016 Notes: Poster presentation.
Brian J. Anderson, Colin Christie, Ryan Tino, Kristy Ramphal, Alex Wysoczanski, Miranda Theodore, Nancy Blumenthal, Jaclyn Golato, Eric Hobson, Kevin Carney, James Mendez, Christian A. Bermudez, Edward Cantu, Joshua M. Diamond: Neuron Specific Enolase Is an Early Marker of Delirium Following Lung Transplantation. American Journal of Respiratory and Critical Care Medicine 193: A4672, May 2016 Notes: Poster presentation.
C. D’Errico, M. Hotz, E. Cantu, M. Porteous, M. Oyster, R. Shah, S. Arcasoy, L. Snyder, K.M. Wille, M. Hartwig, L.B. Ware, P. Shah, M. Crespo, C. Hage, A. Weinacker, V. Lama, Y. Suzuki, J. Orens, S. Kawut, S. Palmer, D.J. Lederer, J.D. Christie, N. Mangalmurti, J.M. Diamond: Plasma RIP3 Is Decreased in PGD after Lung Transplantation. The Journal of Heart and Lung Transplantation 35(4): S87, April 2016 Notes: Poster presentation.
C. Borders, Y. Suzuki, C. Schaufler, J. Lasky, D. Mallem, J. Lee, K. Carney, C. Bermudez, J. Diamond, J. Christie, E. Cantu: Massive Donor Transfusion Increases Recipient Early Mortality after Lung Transplantation. The Journal of Heart and Lung Transplantation 35(4): S370, April 2016 Notes: Poster presentation.
E. Cantu, J. Diamond, J. Nellen, B. Beduhn, Y. Suzuki, C. Borders, J. Lasky, C. Schaufler, R. Shah, M. Porteous, D.J. Lederer, S.M. Kawut, S. Arcasoy, S.M. Palmer, L. Snyder, M.G. Hartwig, V.N. Lama, M. Crespo, K. Wille, J. Orens, P.D. Shah, A. Weinacker, L.B. Ware, S.L. Bellamy, J.D. Christie: Redefining Primary Graft Dysfunction after Lung Transplantation. The Journal of Heart and Lung Transplantation 35(4): S89, April 2016 Notes: Poster presentation.
Cantu E, Suzuki Y, Diamond J M, Ellis J, Tiwari J, Beduhn B, Nellen J R, Shah R, Meyer N J, Lederer D J, Kawut S M, Palmer S M, Snyder L D, Hartwig M G, Lama V N, Bhorade S, Crespo M, Demissie E, Wille K, Orens J, Shah P D, Weinacker A, Weill D, Wilkes D, Roe D, Ware L B, Wang F, Feng R, Christie J D: Protein Quantitative Trait Loci Analysis Identifies Genetic Variation in the Innate Immune Regulator TOLLIP in Post-Lung Transplant Primary Graft Dysfunction Risk. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 16(3): 833-40, March 2016.
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Last updated: 12/08/2016
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