My research is focused on translational studies of clinical and genetic risk factors for Primary Graft Dysfunction (PGD) and chronic rejection after lung transplantation. In addition to increased perioperative mortality, patients recovering from severe PGD have decreased quality of life and an increase risk of chronic rejection, the leading obstacle to long term survival after lung transplantation. Therefore, studies of the mechanisms of PGD and BOS will have a significant impact on the field of lung transplantation and may lead to therapies that improve the overall survival of lung transplant recipients. My current primary research interest is evaluating the role of innate immune activation in the development of post-lung transplant PGD and chronic rejection. I am also actively involved in integrating data on differential innate immune activation with the expanding body of knowledge on microbial colonization and infection of the lower respiratory tract as part of our evaluation of the microbiome of lung transplant recipients
My clinical practice is focused on Advanced Lung Disease and Lung Transplantation. My outpatient practice is at the Penn Lung Center and is predominantly composed of patients before and after lung transplantation. I also have a significant role in Critical Care Medicine, with a primary practice in the Medical Intensive Care Unit at the Hospital of the University of Pennsylvania. Additionally, my practice includes attending on the Procedure and Rapid Response service at the Hospital of the University of Pennsylvania, as well as at the Long Term Acute Care Hospital, at Good Shepard Penn Partners.
Cantu E, Suzuki Y, Diamond J M, Ellis J, Tiwari J, Beduhn B, Nellen J R, Shah R, Meyer N J, Lederer D J, Kawut S M, Palmer S M, Snyder L D, Hartwig M G, Lama V N, Bhorade S, Crespo M, Demissie E, Wille K, Orens J, Shah P D, Weinacker A, Weill D, Wilkes D, Roe D, Ware L B, Wang F, Feng R, Christie J D: Protein Quantitative Trait Loci Analysis Identifies Genetic Variation in the Innate Immune Regulator TOLLIP in Post-Lung Transplant Primary Graft Dysfunction Risk. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 16(3): 833-40, March 2016.
Anderson Brian J, Diamond Joshua M: Under Pressure: Reduced Cerebral Perfusion as a Risk Factor for Postoperative Delirium in Lung Transplant Recipients. Annals of the American Thoracic Society 13(2): 156-7, Feb 2016.
Diamond J M, Shah R J, Cantu E, Porteous M K, Christie J D: Survey of Lung Transplant Community's Views on Primary Graft Dysfunction. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 16(2): 724-6, Feb 2016.
Porteous Mary K, Ky Bonnie, Kirkpatrick James N, Shinohara Russell, Diamond Joshua M, Shah Rupal J, Lee James C, Christie Jason D, Kawut Steven M: Diastolic Dysfunction Increases the Risk of Primary Graft Dysfunction After Lung Transplantation. American journal of respiratory and critical care medicine Jan 2016.
Diamond Joshua M, Porteous Mary K, Jackson Roberts L, Wickersham Nancy, Rushefski Melanie, Kawut Steven M, Shah Rupal J, Cantu Edward, Lederer David J, Chatterjee Shampa, Lama Vibha N, Bhorade Sangeeta, Crespo Maria, McDyer John, Wille Keith, Orens Jonathan, Weinacker Ann, Arcasoy Selim, Shah Pali D, Wilkes David S, Hage Chadi, Palmer Scott M, Snyder Laurie, Calfee Carolyn S, Ware Lorraine B, Christie Jason D: The relationship between plasma lipid peroxidation products and primary graft dysfunction after lung transplantation is modified by donor smoking and reperfusion hyperoxia. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation Jan 2016.
Laurel A Monticelli, Michael D Buck, Anne-Laure Flamar, Steven A Saenz, Elia D Tait Wojno, Naomi A Yudanin, Lisa C Osborne, Matthew R Hepworth, Sara V Tran, Hans-Reimer Rodewald, Hardik Shah, Justin R Cross, Joshua M Diamond, Edward Cantu, Jason D Christie, Erika L Pearce, David Artis: Arginase 1 is an innate lymphoid-cell-intrinsic metabolic checkpoint controlling type 2 inflammation. Nature Immunology. Nature Publishing Group, 2016.
Singer Jonathan P, Diamond Joshua M, Gries Cynthia J, McDonnough Jamiela, Blanc Paul D, Shah Rupal, Dean Monica Y, Hersh Beverly, Wolters Paul J, Tokman Sofya, Arcasoy Selim M, Ramphal Kristy, Greenland John R, Smith Nancy, Heffernan Pricilla, Shah Lori, Shrestha Pavan, Golden Jeffrey A, Blumenthal Nancy P, Huang Debbie, Sonett Joshua, Hays Steven, Oyster Michelle, Katz Patricia P, Robbins Hilary, Brown Melanie, Leard Lorriana E, Kukreja Jasleen, Bacchetta Matthew, Bush Errol, D'Ovidio Frank, Rushefski Melanie, Raza Kashif, Christie Jason D, Lederer David J: Frailty Phenotypes, Disability, and Outcomes in Adult Candidates for Lung Transplantation. American journal of respiratory and critical care medicine 192(11): 1325-34, Dec 2015.
Porteous Mary K, Diamond Joshua M, Christie Jason D: Primary graft dysfunction: lessons learned about the first 72 h after lung transplantation. Current opinion in organ transplantation Aug 2015.
Shah R J, Diamond J M, Cantu E, Flesch J, Lee J C, Lederer D J, Lama V N, Orens J, Weinacker A, Wilkes D S, Roe D, Bhorade S, Wille K M, Ware L B, Palmer S M, Crespo M, Demissie E, Sonnet J, Shah A, Kawut S M, Bellamy S L, Localio A R, Christie J D: Objective Estimates Improve Risk Stratification for Primary Graft Dysfunction after Lung Transplantation. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons Apr 2015.
Eberlein Michael, Reed Robert M, Bolukbas Servet, Diamond Joshua M, Wille Keith M, Orens Jonathan B, Brower Roy G, Christie Jason D: Lung size mismatch and primary graft dysfunction after bilateral lung transplantation. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 34(2): 233-40, Feb 2015.
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Last updated: 04/15/2016
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