Penn Lung Center

Faculty & Staff

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Joshua M. Diamond, MD, MSCE

Assistant Professor of Medicine at the Hospital of the University of Pennsylvania
Department: Medicine

Contact information
Hospital of the University of Pennsylvania
3400 Spruce St.
5035 West Gates
Philadelphia, PA 19104
Office: 215-615-5030
Education:
B.S. (Microbiology and Immunology)
University of Rochester, 2000.
M.D. (Medicine)
University of Rochester School of Medicine and Dentistry, 2004.
M.S.C.E. (Clinical Epidemiology)
University of Pennsylvania, 2011.
Post-Graduate Training
Intern in Internal Medicine, Hospital of the University of Pennsylvania, 2004-2005.
Resident in Internal Medicine, Hospital of the University of Pennsylvania, 2005-2007.
Chief Resident in Internal Medicine, Hospital of the University of Pennsylvania, 2007-2008.
Fellow in Pulmonary and Critical Care Medicine, Hospital of the University of Pennsylvania, 2008-2011.
Certifications
American Board of Internal Medicine - Internal Medicine, 2007.
American Board of Internal Medicine - Pulmonary Medicine, 2010.
American Board of Internal Medicine - Critical Care, 2012.
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Description of Research Expertise

My research is focused on translational studies of clinical and genetic risk factors for Primary Graft Dysfunction (PGD) and chronic rejection after lung transplantation. In addition to increased perioperative mortality, patients recovering from severe PGD have decreased quality of life and an increase risk of chronic rejection, the leading obstacle to long term survival after lung transplantation. Therefore, studies of the mechanisms of PGD and BOS will have a significant impact on the field of lung transplantation and may lead to therapies that improve the overall survival of lung transplant recipients. My current primary research interest is evaluating the role of innate immune activation in the development of post-lung transplant PGD and chronic rejection. I am also actively involved in integrating data on differential innate immune activation with the expanding body of knowledge on microbial colonization and infection of the lower respiratory tract as part of our evaluation of the microbiome of lung transplant recipients

Description of Clinical Expertise

My clinical practice is focused on Advanced Lung Disease and Lung Transplantation. My outpatient practice is at the Penn Lung Center and is predominantly composed of patients before and after lung transplantation. I also have a significant role in Critical Care Medicine, with a primary practice in the Medical Intensive Care Unit at the Hospital of the University of Pennsylvania. Additionally, my practice includes attending on the Procedure and Rapid Response service at the Hospital of the University of Pennsylvania, as well as at the Long Term Acute Care Hospital, at Good Shepard Penn Partners.

Selected Publications

Diamond Joshua M, Ahya Vivek N: Mechanical ventilation after lung transplantation. It's time for a trial. Annals of the American Thoracic Society 11(4): 598-9, May 2014.

Cohen DG, Christie JD, Anderson BJ, Diamond JM, Judy RP, Shah RJ, Cantu E, Bellamy SL, Blumenthal NP, Demissie E, Hopkins RO, Mikkelsen ME: Cognitive function, mental health, and health-related quality of life after lung transplantation. Annals of the American Thoracic Society 11(4): 522-30, May 2014.

Suzuki Y, Tiwari JL, Plumenthal NP, Lee J, Diamond JM, Carney K, Borders C, Strain J, Alburger GW, Jackson D, Timar J, Berg J, Hasz RD, Halpern SD, Cantu E: Should We Reconsider Lung Transplantation Through Uncontrolled Donation After Circulatory Death? American Journal of Transplantation 14(4): 966-71, April 2014.

Shah RJ, Wickersham N, Lederer DJ, Palmer SM, Cantu E, Diamond JM, Kawut SM, Lama VN, Bhorade S, Crespo M, Demissie E, Sonett J, Wille K, Orens J, Weinacker A, Shah P, Arcasoy S, Wilkes DS, Christie JD, Ware LB: Preoperative plasma club (clara) cell secretory protein levels are associated with primary graft dysfunction after lung transplantation. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 14(2): 446-52, Feb 2014.

Diamond JM, Akimova T, Kazi A, Shah RJ, Cantu E, Feng R, Levine MH, Kawut SM, Meyer NJ, Lee JC, Hancock WW, Aplenc R, Ware LB, Palmer SM, Bhorade S, Lama VN, Weinacker A, Orens J, Wille K, Crespo M, Lederer DJ, Arcasoy S, Demissie E, Christie JD: Genetic Variation in Prostaglandin E2 Pathway is Associated with Primary Graft Dysfunction. American journal of respiratory and critical care medicine Jan 2014.

Cantu E, Shah RJ, Lin W, Daye ZJ, Diamond JM, Suzuki Y, Ellis JH, Borders CF, Andah GA, Beduhn B, Meyer NJ, Ruschefski M, Aplenc R, Feng R, Christie JD: Oxidant stress regulatory genetic variation in recipients and donors contributes to risk of primary graft dysfunction after lung transplantation. The Journal of Thoracic and Cardiovascular Surgery In press 2014.

Baldwin MR, Peterson ER, Easthausen I, Quintanilla I, Colago E, Sonett JR, D'Ovidio F, Costa J, Diamond JM, Christie JD, Arcasoy SM, Lederer DJ: Donor age and early graft failure after lung transplantation: a cohort study. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 13(10): 2685-95, Oct 2013.

Shah RJ, Diamond JM, Cantu E, Lee JC, Lederer DJ, Lama VN, Orens J, Weinacker A, Wilkes DS, Bhorade S, Wille KM, Ware LB, Palmer SM, Crespo M, Localio AR, Demissie EJ, Kawut SM, Bellamy SL, Christie JD: Latent class analysis identifies distinct phenotypes of primary graft dysfunction after lung transplantation. Chest 144(2): 616-622, August 2013.

Diamond Joshua M, Wigfield Christopher H: Role of innate immunity in primary graft dysfunction after lung transplantation. Current opinion in organ transplantation 18(5): 518-523, Aug 2013.

Cantu E, Lederer DJ, Meyer K, Milewski K, Suzuki Y, Shah RJ, Diamond JM, Meyer NJ, Tbias JW, Baldwin DA, Van Deerlin VM, Olthoff KM, Shaked A, Christie JD for the CTOT Investigators : Gene Set Enrichment Analysis Identifies Key Innate Immune Pathways in Primary Graft Dysfunction After Lung Transplantation. American Journal of Transplantation 13(7): 1898-1904, July 2013.

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Last updated: 10/03/2014
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