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Joshua M. Diamond, MD, MSCE

Assistant Professor of Medicine at the Hospital of the University of Pennsylvania
Associate Medical Director, Lung Transplantation, University of Pennsylvania
Director Clinical Research Track, University of Pennsylvania - Pulmonary Critical Care Fellowship training program
HUP Regional UNOS Representative, United Network for Organ Sharing
Department: Medicine

Contact information
Hospital of the University of Pennsylvania
3400 Spruce St.
821 West Gates
Philadelphia, PA 19104
Office: 215-615-5030
Education:
B.S. (Microbiology and Immunology)
University of Rochester, 2000.
M.D. (Medicine)
University of Rochester School of Medicine and Dentistry, 2004.
M.S.C.E. (Clinical Epidemiology)
University of Pennsylvania, 2011.
Post-Graduate Training
Intern in Internal Medicine, Hospital of the University of Pennsylvania, 2004-2005.
Resident in Internal Medicine, Hospital of the University of Pennsylvania, 2005-2007.
Chief Resident in Internal Medicine, Hospital of the University of Pennsylvania, 2007-2008.
Fellow in Pulmonary and Critical Care Medicine, Hospital of the University of Pennsylvania, 2008-2011.
Certifications
American Board of Internal Medicine - Internal Medicine, 2007.
American Board of Internal Medicine - Pulmonary Medicine, 2010.
American Board of Internal Medicine - Critical Care, 2012.
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Description of Research Expertise

My research is focused on translational studies of clinical and genetic risk factors for Primary Graft Dysfunction (PGD) and chronic rejection after lung transplantation. In addition to increased perioperative mortality, patients recovering from severe PGD have decreased quality of life and an increase risk of chronic rejection, the leading obstacle to long term survival after lung transplantation. Therefore, studies of the mechanisms of PGD and BOS will have a significant impact on the field of lung transplantation and may lead to therapies that improve the overall survival of lung transplant recipients. My current primary research interest is evaluating the role of innate immune activation in the development of post-lung transplant PGD and chronic rejection. I am also actively involved in integrating data on differential innate immune activation with the expanding body of knowledge on microbial colonization and infection of the lower respiratory tract as part of our evaluation of the microbiome of lung transplant recipients

Description of Clinical Expertise

My clinical practice is focused on Advanced Lung Disease and Lung Transplantation. My outpatient practice is at the Penn Lung Center and is predominantly composed of patients before and after lung transplantation. I also have a significant role in Critical Care Medicine, with a primary practice in the Medical Intensive Care Unit at the Hospital of the University of Pennsylvania. Additionally, my practice includes attending on the Procedure and Rapid Response service at the Hospital of the University of Pennsylvania, as well as at the Long Term Acute Care Hospital, at Good Shepard Penn Partners.

Selected Publications

Cantu Edward, Diamond Joshua M, Suzuki Yoshikazu, Lasky Jared, Schaufler Christian, Lim Brian, Shah Rupal, Porteous Mary, Lederer David J, Kawut Steven M, Palmer Scott M, Snyder Laurie D, Hartwig Matthew G, Lama Vibha N, Bhorade Sangeeta, Bermudez Christian, Crespo Maria, McDyer John, Wille Keith, Orens Jonathan, Shah Pali D, Weinacker Ann, Weill David, Wilkes David, Roe David, Hage Chadi, Ware Lorraine B, Bellamy Scarlett L, Christie Jason D: Quantitative Evidence for Revising the Definition of Primary Graft Dysfunction After Lung Transplant. American journal of respiratory and critical care medicine Sep 2017.

Akimova Tatiana, Zhang Tianyi, Negorev Dmitri, Singhal Sunil, Stadanlick Jason, Rao Abhishek, Annunziata Michael, Levine Matthew H, Beier Ulf H, Diamond Joshua M, Christie Jason D, Albelda Steven M, Eruslanov Evgeniy B, Hancock Wayne W: Human lung tumor FOXP3+ Tregs upregulate four "Treg-locking" transcription factors. JCI insight 2(16), Aug 2017.

Diamond Joshua M, Arcasoy Selim, Kennedy Cassie C, Eberlein Michael, Singer Jonathan P, Patterson Glenda M, Edelman Jeffrey D, Dhillon Gundeep, Pena Tahuanty, Kawut Steven M, Lee James C, Girgis Reda, Dark John, Thabut Gabriel: Report of the International Society for Heart and Lung Transplantation Working Group on Primary Lung Graft Dysfunction, part II: Epidemiology, risk factors, and outcomes-A 2016 Consensus Group statement of the International Society for Heart and Lung Transplantation. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation Jul 2017.

Porteous Mary K, Lee James C, Lederer David J, Palmer Scott M, Cantu Edward, Shah Rupal J, Bellamy Scarlett L, Lama Vibha N, Bhorade Sangeeta M, Crespo Maria M, McDyer John F, Wille Keith M, Localio A Russell, Orens Jonathan B, Shah Pali D, Weinacker Ann B, Arcasoy Selim, Wilkes David S, Ware Lorraine B, Christie Jason D, Kawut Steven M, Diamond Joshua M: Clinical Risk Factors and Prognostic Model for Primary Graft Dysfunction after Lung Transplantation in Patients with Pulmonary Hypertension. Annals of the American Thoracic Society Jul 2017.

Vallabhajosyula Prashanth, Korutla Laxminarayana, Habertheuer Andreas, Reddy Sanjana, Schaufler Christian, Lasky Jared, Diamond Joshua, Cantu Edward: Ex Vivo Lung Perfusion Model to Study Pulmonary Tissue Extracellular Microvesicle Profiles. The Annals of thoracic surgery 103(6), Jun 2017.

Abbas A A, Diamond J M, Chehoud C, Chang B, Kotzin J J, Young J C, Imai I, Haas A R, Cantu E, Lederer D J, Meyer K, Milewski R K, Olthoff K M, Shaked A, Christie J D, Bushman F D, Collman R G: The Perioperative Lung Transplant Virome: Torque Teno Viruses are Elevated in Donor Lungs and Show Divergent Dynamics In Primary Graft Dysfunction. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 17(5): 1313-24, May 2017.

Borders Catherine F, Suzuki Yoshikazu, Lasky Jared, Schaufler Christian, Mallem Djamila, Lee James, Carney Kevin, Bellamy Scarlett L, Bermudez Christian A, Localio A Russell, Christie Jason D, Diamond Joshua M, Cantu Edward: Massive donor transfusion potentially increases recipient mortality after lung transplantation. The Journal of thoracic and cardiovascular surgery 153(5): 1197-1203.e2, May 2017.

T.I. Carter, Y. Suzuki, J. Lasky, C. Schaufler, B. Lim, D. Mallem, C.A. Bermudez, J.M. Diamond, J.D. Christie, X. Yu, R. Feng, E. Cantu: An In Situ Donor Derived Panel of Innate Immune Transcripts Predicts Primary Graft Dysfunction in Lung Transplant Recipients. The Journal of Heart and Lung Transplantation 36(4): S145-146, April 2017.

A. Courtwright, D. Zaleski, V. Ahya, C. Bermudez, N. Blumenthal, E. Cantu, J. Christie, T. Claridge, M. Crespo, J. Golato, D. Hadjiliadis, E. Hobson, J. Lee, M. Molina, N. Patel, M. Porteous, J. Diamond: Causes and Preventability of Unplanned Rehospitalization Following Lung Transplantation. The Journal of Heart and Lung Transplantation 36(4), April 2017.

C. Schaufler, J. Lasky, B. Lim, Y. Suzuki, D. Mallem, M. Oyster, D.J. Lederer, K. Meyer, C.A. Bermudez, J. Tobias, V.M. Van Deerlin, K. Olthoff, A. Shaked, J.M. Diamond, E. Cantu, J.D. Christie : Gene Set Enrichment Analysis Identifies a Potential Link Between Smoking and Upregulation of Olfactory Receptor and Cytokine Enrichment Pathways. The Journal of Heart and Lung Transplantation 36(4): S417, April 2017.

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Last updated: 09/07/2017
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