Institute for Environmental Medicine

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Suiping Zhou, Ph.D.

Sr. Research Investigator, University of Pennsylvania, Institute for Environmental Medicine

Contact information
3620 Hamilton Walk
Philadelphia, PA 19104
Office: 215-898-5647
Fax: 215-898-0868
Jiangxi Medical College, Nanchang, Jiangxi, PRC, 1984.
Ph.D. (Biochemistry)
Simon Fraser University, Burnaby, BC Canada, 2003.
Post-Graduate Training
Postdoctoral Fellow, Children's Hospital of Philadelphia, 2003-2006.
Senior Research Fellow, MGH Harvard Medical School, 2006-2008.
Permanent link
> Perelman School of Medicine   > Faculty   > Details

Description of Research Expertise

Research Interests
Protein-protein interaction in acute lung injury

Key words
Oxidants, antioxidant enzymes, protein-protein interaction.

Research description
Prdx6 is a non-selenium GSH peroxidase that has an important role in anti-oxidant defense. Using in vitro assay and by liposome-mediated delivery of the two proteins into the cells, we have shown previously that the regeneration of Prdx6’s peroxidase activity requires piGST. Now, we plan to confirm this finding in cell culture studies using the Duolink Proximity Ligation Assay, siRNA knockdown, and co-transfection approaches.

Selected Publications

Zhou S, Lien YC, Shuvaeva T, Debolt K, Feinstein SI, Fisher AB: Functional interaction of glutathione S-transferase pi and peroxiredoxin 6 in intact cells. Int J Biochem Cell Biol. S1357-2725(12): 00368-8, Nov 2012.

Rahaman H, Zhou S, Dodia C, Feinstein SI, Huang S, Speicher D, Fisher AB: Increased phospholipase A2 activity with phosphorylation of peroxiredoxin 6 requires a conformational change in the protein. Biochemistry. 51(27): 5521-30, Jul 2012.

Sorokina EM, Feinstein SI, Zhou S, Fisher AB.: Intracellular targeting of peroxiredoxin 6 to lysosomal organelles requires MAPK activity and binding to 14-3-3ε. Am J Physiol Cell Physiol. 300(6): C1430-41, Jun 2011.

Gell DA, Feng L, Zhou S, Jeffrey PD, Bendak K, Gow A, Weiss MJ, Shi Y, Mackay JP.: A cis-proline in alpha-hemoglobin stabilizing protein directs the structural reorganization of alpha-hemoglobin. J Biol Chem. 2009 Oct 23;284(43):. Epub 2009 Aug 25. 284(43): 29462-9, Oct 2009.

Tamehiro N, Mujawar Z, Zhou S, Zhuang DZ, Hornemann T, von Eckardstein A, Fitzgerald ML.: Cell polarity factor Par3 binds SPTLC1 and modulates monocyte serine palmitoyltransferase activity and chemotaxis. J Biol Chem. (eds.). 284(37): 24881-90, Sep 2009.

Tamehiro N, Zhou S (Co-First Author), Okuhira K, Benita Y, Brown CE, Zhuang DZ, Latz E, Hornemann T, von Eckardstein A, Xavier RJ, Freeman MW, Fitzgerald ML.: SPTLC1 Binds ABCA1 To Negatively Regulate Trafficking and Cholesterol Efflux Activity of the Transporter. Biochemistry. Biochemistry 47(23): 6138-47, June 2008.

Yu X, Kong Y, Dore LC, Abdulmalik O, Katein AM, Zhou S, Choi JK, Gell D, Mackay JP, Gow AJ, Weiss MJ: An erythroid chaperone that facilitates folding of alpha-globin subunits for hemoglobin synthesis. J Clin Invest. 117(7): 1856-65, Jul 2007.

Dos Santos CO, Zhou S, Secolin R, Wang X, Cunha AF, Higgs DR, Kwiatkowski JL, Thein SL, Gallagher PG, Costa FF, Weiss MJ.: Population analysis of the alpha hemoglobin stabilizing protein (AHSP) gene identifies sequence variants that alter expression and function. Am J Hematol. 83(2): 103-108, September 2007.

Zhou S, Olson JS, Fabian M, Weiss MJ, Gow AJ.: Biochemical fates of alpha hemoglobin bound to alpha hemoglobin-stabilizing protein AHSP. J Biol Chem 281(43): 32611-32618, October 2006.

Feng L, Zhou S (Co-First Author), Gu L, Gell D, Mackay J, Weiss M, Gow A, and Shi Y.: Structure of oxidized alpha-hemolgobin bound to AHSP reveals a protective mechanism for heme. Nature 435(7042): 697-710, June 2005.

Weiss M, Zhou S, Feng L, Gell D, Mackay J, Shi Y, and Gow A.: The role of alpha hemoglobin stabilizing protein in normal erythropoiesis and beta-thalassemia. Ann. N. Y. Acad. Sci. 1054: 1-15, 2005.

Feng L, Gell D, Zhou S (Co-First Author), Gu L, Kong Y, Li J, Hu M, Yan N, Lee C, Rich A, Armstrong R, Lay P, Gow A, Weiss M, Mackay J, Shi Y. : Molecular mechanism of AHSP-mediated stabilization of alpha-hemoglobin. Cell. 119(5): 629-640, November 2004.

Zhou S, Yao Y, Davison A, Vieira A.: A cytochrome c-enhanced peroxidation reaction with potential use in screening dietary antioxidants. J Pharm Biomed Anal. 34(5): 1057-61, Mar 2004.

Kong Y, Zhou S, Kihm A, Katein A, Yu X, Gell D, Mackay J, Adachi K, Foster-Brown L, Louden C, Gow A, Weiss M.: Loss of alpha-hemoglobin-stabilizing protein impairs erythropoiesis and exacerbates beta-thalassemia. J Clin Invest. 114(10): 1457-66, Nov 2004.

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Last updated: 06/05/2013
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