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Ian A. Blair, Ph.D.

A.N. Richards Professor of Pharmacology
Director, Center for Cancer Pharmacology, University of Pennsylvania School of Medicine
Investigator, Abramson Cancer Center, University of Pennsylvania School of Medicine
Member, Institute for Medicine and Engineering, University of Pennsylvania School of Medicine
Investigator, Genomics Institute, University of Pennsylvania School of Medicine
Scientific Director, Proteomics Core Laboratory, Genomics Institute and Abramson Cancer Center, University of Pennsylvania School of Medicine
Vice Chair, Department of Pharmacology, University of Pennsylvania School of Medicine
Scientific Director, Mass Spectrometry Facility, Department of Chemistry, University of Pennsylvania
Director, Program in Systems Biology, Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine
Member, Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine
Department: Pharmacology

Contact information
854 Biomedical Research Building II/III
University of Pennsylvania School of Medicine
Center for Cancer Pharmacology
421 Curie Boulevard
Philadelphia, PA 19104-6160
Office: (215) 573-9880
Fax: (215) 573-9889
Graduate Group Affiliations
Education:

Cambridge Grammar School for Boys, United Kingdom , 1960.

Prince of Wales School, Nairobi, Kenya, 1963.
B.Sc. ((Special) Chemistry, ARCS)
Imperial College of Science and Technology, University of London, United Kingdom, 1968.
Ph.D.
Imperial College of Science and Technology, University of London, United Kingdom, 1971.
MRSC (Organic Chemistry)
Adelaide University, Australia, 1972.
ARACI
Australian National University, 1977.
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Description of Research Expertise

Oxidative stress, carcinogenesis, cardiovascular disease, and neurodegenerative disease
Oxidative stress results in damage to lipids through the formation of lipid hydroperoxides. Our laboratory is involved in determining the factors that control lipid hydroperoxide-mediated damage to DNA, and proteins. We are also characterizing the lesions in these macromolecules using novel mass spectrometry methodology, determining how the lesions affect proliferation and apoptosis using model in vitro systems, and assessing how such processes can be prevented using novel pharmacological agents. We also have a program in biomarker discovery and analysis, which is focused on metabolomic and proteomic biomarkers of smoking, pancreatic cancer, breast cancer, and neurodegenerative diseases. This involves the use of quantitative stable isotope dilution liquid chromatography-mass spectrometry methodology. We recently implement the use of stable isotope dilution by essential nutrients in cell culture (SILEC) as a method for analyzing important Krebs cycle coenzyme A-thioesters. This has made it possible to examine the effects of chemicals and disease on mitochondrial dysfunction.

Selected Publications

Mesaros C, Blair IA.: Mass spectrometry-based approaches to targeted quantitative proteomics in cardiovascular disease. Clin Proteom 13:20. eCollection, October 2016

Pinney SE, Mesaros CA, Snyder NW, Busch CM, Xiao R, Aijaz S, Ijaz N, Blair IA, Manson JM. : Second trimester amniotic fluid bisphenol a concentration is associated with decreased birth weight in term infants. Reprod Toxicol. November 2016 Notes: pii: S0890-6238(16)30403-8. doi: 10.1016/j.reprotox.2016.11.007. [Epub ahead of print]

Pinney SE, Mesaros CA, Snyder NW, Busch CM, Xiao R, Aijaz S, Ijaz N, Blair IA, Manson JM: Second trimester amniotic fluid bisphenol a concentration is associated with decreased birth weight in term infants. Reprod Toxicol. November 2016.

Zhao S, Torres A, Henry RA, Trefely S, Wallace M, Lee JV, Carrer A, Sengupta A, Campbell SL, Kuo YM, Frey AJ, Meurs N, Viola JM, Blair IA, Weljie AM, Metallo CM, Snyder NW, Andrews AJ, Wellen KE. : ATP-Citrate Lyase Controls a Glucose-to-Acetate Metabolic Switch. Cell Rep. 17(4): 1037-1052, October 2016.

Bagley SJ, Vitale S, Zhang S, Aggarwal C, Evans TL, Alley EW, Cohen RB, Langer CJ, Blair IA, Vachani A, Whitehead AS: Pretreatment Red Blood Cell Total Folate Concentration Is Associated With Response to Pemetrexed in Stage IV Nonsquamous Non-Small-cell Lung Cancer. Clin Lung Cancer October 2016.

Zhao S, Torres A, Henry RA, Trefely S, Wallace M, Lee JV, Carrer A, Sengupta A, Campbell SL, Kuo YM, Frey AJ, Meurs N, Viola JM, Blair IA, Weljie AM, Metallo CM, Snyder NW, Andrews AJ, Wellen KE.: ATP-Citrate Lyase Controls a Glucose-to-Acetate Metabolic Switch. Cell Rep 177(4): 1037-1052, October 2016.

Frey AJ, Wang Q, Busch C, Feldman D, Bottalico L, Mesaros CA, Blair IA, Vachani A, Snyder NW.: Validation of highly sensitive simultaneous targeted and untargeted analysis of keto-steroids by Girard P derivatization and stable isotope dilution-liquid chromatography-high resolution mass spectrometry. Steroids 116: 60-66, October 2016.

Wang Q, Mesaros C, Blair IA. : Ultra-high sensitivity analysis of estrogens for special populations in serum and plasma by liquid chromatography-mass spectrometry: Assay considerations and suggested practices. J Steroid Biochem Mol Biol. 162: 70-79, September 2016.

Zhao X, Lorent K, Wilkins B, Marchione DM, Gillespie K, Waisbourd-Zinman O, So J, Koo KA, Shin D, Porter JR, Wells RG, Blair I, Pack M: Glutathione antioxidant pathway activity and reserve determine toxicity and specificity of the biliary toxin biliatresone in zebrafish. Hepatology 64(3): 894-907, September 2016.

Mazaleuskaya LL, Lawson JA, Li X, Grant G, Mesaros C, Grosser T, Blair IA, Ricciotti E, FitzGerald GA. : A broad-spectrum lipidomics screen of antiinflammatory drug combinations in human blood. J CIin Inv. 1(12): pii: e87031, August 2016.

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Last updated: 12/01/2016
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