faculty photo

Sandhitsu Das, Ph.D.

Research Associate Professor of Neurology
Department: Neurology

Contact information
University of Pennsylvania
3700 Hamilton Walk, Fl 6
Philadelphia, PA 19104
Office: (267) 408-3001
Fax: (215) 573-2701
Education:
B. Tech (Electrical Engineering)
Indian Institute of Technology, 1997.
M. Tech (Digital Signal Processing)
Indian Institute of Technology, 1999.
Ph.D. (Neuroengineering)
University of Pennsylvania, 2006.
Post-Graduate Training
Postdoctoral Fellow, University of Pennsylvania, Penn Image Computing and Science Laboratory, Department of Radiology, 2006-2008.
Permanent link
 
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Selected Publications

Huang LY, Tan CC, Xu W, Tan L; Alzheimer’s Disease Neuroimaging Initiative.: Relationships of PGRN with sTREM2 in AD continuum and non-AD pathophysiology and their reciprocal roles in modulating amyloid pathology: two population-based study. Transl Psychiatry 15: 233, Jul 2025.

Brown CA, Mundada NS, Cousins KAQ, Sadeghpour N, Lyu X, McGrew E, Korecka M, Chen-Plotkin A, Xie L, Wisse LEM, Detre JA, McMillan CT, Lee EB, Nasrallah IM, Das SR, Mechanic-Hamilton D, Yushkevich PA, Shaw LM; Alzheimer’s Disease Neuroimaging Initiative; Wolk DA.: Tau-Clinical Mismatch Identifies Individuals with Co-Pathology and Predicts Clinical Trajectory. medRxiv Jul 2025.

Gugger JJ, Kulick-Soper CV, Sinha N, Jaskir M, Hadar PN, Josyula M, Petillo N, Raghupathi R, Shinohara RT, Das S, Stein JM, Davis KA.: Evaluation of limbic microstructural abnormalities in temporal lobe epilepsy: A neurite orientation distribution and density imaging study. Epilepsia Jun 2025.

Athalye C, Bahena A, Khandelwal P, Emrani S, Trotman W, Levorse LM, Khodakarami Z, Ohm DT, Teunissen-Bermeo E, Capp N, Sadaghiani S, Arezoumandan S, Lim SA, Prabhakaran K, Ittyerah R, Robinson JL, Schuck T, Lee EB, Tisdall MD, Das SR, Wolk DA, Irwin DJ, Yushkevich PA.: Operationalizing postmortem pathology-MRI association studies in Alzheimer's disease and related disorders with MRI-guided histology sampling. Acta Neuropathol Commun 13: 120, May 2025.

Lucas A, Cornblath EJ, Sinha N, Caciagli L, Hadar P, Tranquille A, Stein JM, Das S, Davis KA.: Seizure-onset zone lateralization in temporal lobe epilepsy using 7T rs-fMRI: Direct comparison with 3T rs-fMRI. Epilepsia May 2025.

Cohen JS, Radhakrishnan H, Olm CA, Das SR, Cook PA, Wolk DA, Weintraub D, Irwin DJ, McMillan CT.: Microstructural Changes in the Tuberal Hypothalamus Correlate with Daytime Sleepiness in Lewy Body Disorders. Mov Disord May 2025.

Christopher A Brown; Manuel Taso; Sandhitsu R. Das; Danielle Hing; Emily McGrew; Paul A. Yushkevich; Dawn Mechanic-Hamilton; Ilya M. Nasrallah, MD; David C Alsop; John A. Detre and David A. Wolk: Microstructural and Water Exchange Alterations in ARIA-E in a Real-World Cohort Receiving Anti-Amyloid Therapy. AAIC 2025 2025.

Brown CA, Das SR, Cousins KAQ, Tropea TF, Plotkin AC, Detre JA, Yushkevich PA, McMillan CT, Lee EB, Shaw LM, Nasrallah IM; Alzheimer's Disease Neuroimaging Initiative; Wolk DA.: Tau burden is best captured by magnitude and extent: Tau-MaX as a measure of global tau. Alzheimers Dement 2025.

Wuestefeld A, Xie L, McGrew E, Pichet-Binette A, Spotorno N, van Westen D, Mattsson-Carlgren N, Yushkevich PA, Das SR, Wolk DA, Wisse LEM; and for the Alzheimer's Disease Neuroimaging Initiative.: Tau, atrophy, and domain-specific cognitive impairment in typical Alzheimer's disease. Alzheimers Dement 2025.

Zahra Khodakarami; Pulkit Khandelwal; Michael Tran Duong; Amanda E Denning; Sydney A. Lim; Eunice Chung; Alejandra Bahena; Karthik Prabhakaran; Gabor Mizsei; Theresa Schuck; Winifred Trotman; John L. Robinson; Daniel T Ohm; Adam Brickman; Eddie B. Lee, MD; David J. Irwin; John A. Detre; M. Dylan Tisdall; Sandhitsu R. Das; David A. Wolk; Paul A. Yushkevich, and Sheina Emrani: Assessing white matter hyperintensities on matched antemortem and postmortem MRI AAIC 2025 2025.

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Last updated: 08/25/2025
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