faculty photo

Sandhitsu Das, Ph.D.

Research Associate Professor of Neurology
Department: Neurology

Contact information
University of Pennsylvania
3700 Hamilton Walk, Fl 6
Philadelphia, PA 19104
Office: (267) 408-3001
Fax: (215) 573-2701
Education:
B. Tech (Electrical Engineering)
Indian Institute of Technology, 1997.
M. Tech (Digital Signal Processing)
Indian Institute of Technology, 1999.
Ph.D. (Neuroengineering)
University of Pennsylvania, 2006.
Post-Graduate Training
Postdoctoral Fellow, University of Pennsylvania, Penn Image Computing and Science Laboratory, Department of Radiology, 2006-2008.
Permanent link
 
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Selected Publications

Huang LY, Tan CC, Xu W, Tan L; Alzheimer’s Disease Neuroimaging Initiative.: Relationships of PGRN with sTREM2 in AD continuum and non-AD pathophysiology and their reciprocal roles in modulating amyloid pathology: two population-based study. Transl Psychiatry 15: 233, Jul 2025.

Brown CA, Mundada NS, Cousins KAQ, Sadeghpour N, Lyu X, McGrew E, Korecka M, Chen-Plotkin A, Xie L, Wisse LEM, Detre JA, McMillan CT, Lee EB, Nasrallah IM, Das SR, Mechanic-Hamilton D, Yushkevich PA, Shaw LM; Alzheimer’s Disease Neuroimaging Initiative; Wolk DA.: Tau-Clinical Mismatch Identifies Individuals with Co-Pathology and Predicts Clinical Trajectory. medRxiv Jul 2025.

Gugger JJ, Kulick-Soper CV, Sinha N, Jaskir M, Hadar PN, Josyula M, Petillo N, Raghupathi R, Shinohara RT, Das S, Stein JM, Davis KA.: Evaluation of limbic microstructural abnormalities in temporal lobe epilepsy: A neurite orientation distribution and density imaging study. Epilepsia Jun 2025.

Athalye C, Bahena A, Khandelwal P, Emrani S, Trotman W, Levorse LM, Khodakarami Z, Ohm DT, Teunissen-Bermeo E, Capp N, Sadaghiani S, Arezoumandan S, Lim SA, Prabhakaran K, Ittyerah R, Robinson JL, Schuck T, Lee EB, Tisdall MD, Das SR, Wolk DA, Irwin DJ, Yushkevich PA.: Operationalizing postmortem pathology-MRI association studies in Alzheimer's disease and related disorders with MRI-guided histology sampling. Acta Neuropathol Commun 13: 120, May 2025.

Lucas A, Cornblath EJ, Sinha N, Caciagli L, Hadar P, Tranquille A, Stein JM, Das S, Davis KA.: Seizure-onset zone lateralization in temporal lobe epilepsy using 7T rs-fMRI: Direct comparison with 3T rs-fMRI. Epilepsia May 2025.

Cohen JS, Radhakrishnan H, Olm CA, Das SR, Cook PA, Wolk DA, Weintraub D, Irwin DJ, McMillan CT.: Microstructural Changes in the Tuberal Hypothalamus Correlate with Daytime Sleepiness in Lewy Body Disorders. Mov Disord May 2025.

Zahra Khodakarami; Pulkit Khandelwal; Michael Tran Duong; Amanda E Denning; Sydney A. Lim; Eunice Chung; Alejandra Bahena; Karthik Prabhakaran; Gabor Mizsei; Theresa Schuck; Winifred Trotman; John L. Robinson; Daniel T Ohm; Adam Brickman; Eddie B. Lee, MD; David J. Irwin; John A. Detre; M. Dylan Tisdall; Sandhitsu R. Das; David A. Wolk; Paul A. Yushkevich, and Sheina Emrani: Assessing white matter hyperintensities on matched antemortem and postmortem MRI AAIC 2025 2025.

Brown CA, Das SR, Cousins KAQ, Tropea TF, Plotkin AC, Detre JA, Yushkevich PA, McMillan CT, Lee EB, Shaw LM, Nasrallah IM; Alzheimer's Disease Neuroimaging Initiative; Wolk DA.: Tau burden is best captured by magnitude and extent: Tau-MaX as a measure of global tau. Alzheimers Dement 2025.

Wuestefeld A, Xie L, McGrew E, Pichet-Binette A, Spotorno N, van Westen D, Mattsson-Carlgren N, Yushkevich PA, Das SR, Wolk DA, Wisse LEM; and for the Alzheimer's Disease Neuroimaging Initiative.: Tau, atrophy, and domain-specific cognitive impairment in typical Alzheimer's disease. Alzheimers Dement 2025.

Christopher A Brown; Manuel Taso; Sandhitsu R. Das; Danielle Hing; Emily McGrew; Paul A. Yushkevich; Dawn Mechanic-Hamilton; Ilya M. Nasrallah, MD; David C Alsop; John A. Detre and David A. Wolk: Microstructural and Water Exchange Alterations in ARIA-E in a Real-World Cohort Receiving Anti-Amyloid Therapy. AAIC 2025 2025.

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Last updated: 08/25/2025
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