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Sandhitsu Das, Ph.D.
4eResearch Associate Professor of Neurology
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Department: Neurology
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Contact information
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University of Pennsylvania
3b 3700 Hamilton Walk, Fl 6
Philadelphia, PA 19104
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3b 3700 Hamilton Walk, Fl 6
Philadelphia, PA 19104
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Office: (267) 408-3001
35 Fax: (215) 573-2701
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35 Fax: (215) 573-2701
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Education:
21 c B. Tech 23 (Electrical Engineering) c
37 Indian Institute of Technology, 1997.
21 c M. Tech 26 (Digital Signal Processing) c
37 Indian Institute of Technology, 1999.
21 a Ph.D. 1d (Neuroengineering) c
33 University of Pennsylvania, 2006.
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21 c B. Tech 23 (Electrical Engineering) c
37 Indian Institute of Technology, 1997.
21 c M. Tech 26 (Digital Signal Processing) c
37 Indian Institute of Technology, 1999.
21 a Ph.D. 1d (Neuroengineering) c
33 University of Pennsylvania, 2006.
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Post-Graduate Training
24 93 Postdoctoral Fellow, University of Pennsylvania, Penn Image Computing and Science Laboratory, Department of Radiology, 2006-2008.
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Permanent link24 93 Postdoctoral Fellow, University of Pennsylvania, Penn Image Computing and Science Laboratory, Department of Radiology, 2006-2008.
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1c5 Brown CA, Mundada NS, Cousins KAQ, Sadeghpour N, Lyu X, McGrew E, Korecka M, Chen-Plotkin A, Xie L, Wisse LEM, Detre JA, McMillan CT, Lee EB, Nasrallah IM, Das SR, Mechanic-Hamilton D, Yushkevich PA, Shaw LM; Alzheimer’s Disease Neuroimaging Initiative; Wolk DA.: Tau-Clinical Mismatch Identifies Individuals with Co-Pathology and Predicts Clinical Trajectory. medRxiv Jul 2025.
16f Gugger JJ, Kulick-Soper CV, Sinha N, Jaskir M, Hadar PN, Josyula M, Petillo N, Raghupathi R, Shinohara RT, Das S, Stein JM, Davis KA.: Evaluation of limbic microstructural abnormalities in temporal lobe epilepsy: A neurite orientation distribution and density imaging study. Epilepsia Jun 2025.
210 Athalye C, Bahena A, Khandelwal P, Emrani S, Trotman W, Levorse LM, Khodakarami Z, Ohm DT, Teunissen-Bermeo E, Capp N, Sadaghiani S, Arezoumandan S, Lim SA, Prabhakaran K, Ittyerah R, Robinson JL, Schuck T, Lee EB, Tisdall MD, Das SR, Wolk DA, Irwin DJ, Yushkevich PA.: Operationalizing postmortem pathology-MRI association studies in Alzheimer's disease and related disorders with MRI-guided histology sampling. Acta Neuropathol Commun 13: 120, May 2025.
12c Lucas A, Cornblath EJ, Sinha N, Caciagli L, Hadar P, Tranquille A, Stein JM, Das S, Davis KA.: Seizure-onset zone lateralization in temporal lobe epilepsy using 7T rs-fMRI: Direct comparison with 3T rs-fMRI. Epilepsia May 2025.
12d Cohen JS, Radhakrishnan H, Olm CA, Das SR, Cook PA, Wolk DA, Weintraub D, Irwin DJ, McMillan CT.: Microstructural Changes in the Tuberal Hypothalamus Correlate with Daytime Sleepiness in Lewy Body Disorders. Mov Disord May 2025.
1fd Zahra Khodakarami; Pulkit Khandelwal; Michael Tran Duong; Amanda E Denning; Sydney A. Lim; Eunice Chung; Alejandra Bahena; Karthik Prabhakaran; Gabor Mizsei; Theresa Schuck; Winifred Trotman; John L. Robinson; Daniel T Ohm; Adam Brickman; Eddie B. Lee, MD; David J. Irwin; John A. Detre; M. Dylan Tisdall; Sandhitsu R. Das; David A. Wolk; Paul A. Yushkevich, and Sheina Emrani: Assessing white matter hyperintensities on matched antemortem and postmortem MRI 28 AAIC 2025 2025.
16b Brown CA, Das SR, Cousins KAQ, Tropea TF, Plotkin AC, Detre JA, Yushkevich PA, McMillan CT, Lee EB, Shaw LM, Nasrallah IM; Alzheimer's Disease Neuroimaging Initiative; Wolk DA.: Tau burden is best captured by magnitude and extent: Tau-MaX as a measure of global tau. Alzheimers Dement 2025.
17c Wuestefeld A, Xie L, McGrew E, Pichet-Binette A, Spotorno N, van Westen D, Mattsson-Carlgren N, Yushkevich PA, Das SR, Wolk DA, Wisse LEM; and for the Alzheimer's Disease Neuroimaging Initiative.: Tau, atrophy, and domain-specific cognitive impairment in typical Alzheimer's disease. Alzheimers Dement 2025.
18c Christopher A Brown; Manuel Taso; Sandhitsu R. Das; Danielle Hing; Emily McGrew; Paul A. Yushkevich; Dawn Mechanic-Hamilton; Ilya M. Nasrallah, MD; David C Alsop; John A. Detre and David A. Wolk: Microstructural and Water Exchange Alterations in ARIA-E in a Real-World Cohort Receiving Anti-Amyloid Therapy. AAIC 2025 2025.
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Selected Publications
161 Huang LY, Tan CC, Xu W, Tan L; Alzheimer’s Disease Neuroimaging Initiative.: Relationships of PGRN with sTREM2 in AD continuum and non-AD pathophysiology and their reciprocal roles in modulating amyloid pathology: two population-based study. Transl Psychiatry 15: 233, Jul 2025.1c5 Brown CA, Mundada NS, Cousins KAQ, Sadeghpour N, Lyu X, McGrew E, Korecka M, Chen-Plotkin A, Xie L, Wisse LEM, Detre JA, McMillan CT, Lee EB, Nasrallah IM, Das SR, Mechanic-Hamilton D, Yushkevich PA, Shaw LM; Alzheimer’s Disease Neuroimaging Initiative; Wolk DA.: Tau-Clinical Mismatch Identifies Individuals with Co-Pathology and Predicts Clinical Trajectory. medRxiv Jul 2025.
16f Gugger JJ, Kulick-Soper CV, Sinha N, Jaskir M, Hadar PN, Josyula M, Petillo N, Raghupathi R, Shinohara RT, Das S, Stein JM, Davis KA.: Evaluation of limbic microstructural abnormalities in temporal lobe epilepsy: A neurite orientation distribution and density imaging study. Epilepsia Jun 2025.
210 Athalye C, Bahena A, Khandelwal P, Emrani S, Trotman W, Levorse LM, Khodakarami Z, Ohm DT, Teunissen-Bermeo E, Capp N, Sadaghiani S, Arezoumandan S, Lim SA, Prabhakaran K, Ittyerah R, Robinson JL, Schuck T, Lee EB, Tisdall MD, Das SR, Wolk DA, Irwin DJ, Yushkevich PA.: Operationalizing postmortem pathology-MRI association studies in Alzheimer's disease and related disorders with MRI-guided histology sampling. Acta Neuropathol Commun 13: 120, May 2025.
12c Lucas A, Cornblath EJ, Sinha N, Caciagli L, Hadar P, Tranquille A, Stein JM, Das S, Davis KA.: Seizure-onset zone lateralization in temporal lobe epilepsy using 7T rs-fMRI: Direct comparison with 3T rs-fMRI. Epilepsia May 2025.
12d Cohen JS, Radhakrishnan H, Olm CA, Das SR, Cook PA, Wolk DA, Weintraub D, Irwin DJ, McMillan CT.: Microstructural Changes in the Tuberal Hypothalamus Correlate with Daytime Sleepiness in Lewy Body Disorders. Mov Disord May 2025.
1fd Zahra Khodakarami; Pulkit Khandelwal; Michael Tran Duong; Amanda E Denning; Sydney A. Lim; Eunice Chung; Alejandra Bahena; Karthik Prabhakaran; Gabor Mizsei; Theresa Schuck; Winifred Trotman; John L. Robinson; Daniel T Ohm; Adam Brickman; Eddie B. Lee, MD; David J. Irwin; John A. Detre; M. Dylan Tisdall; Sandhitsu R. Das; David A. Wolk; Paul A. Yushkevich, and Sheina Emrani: Assessing white matter hyperintensities on matched antemortem and postmortem MRI 28 AAIC 2025 2025.
16b Brown CA, Das SR, Cousins KAQ, Tropea TF, Plotkin AC, Detre JA, Yushkevich PA, McMillan CT, Lee EB, Shaw LM, Nasrallah IM; Alzheimer's Disease Neuroimaging Initiative; Wolk DA.: Tau burden is best captured by magnitude and extent: Tau-MaX as a measure of global tau. Alzheimers Dement 2025.
17c Wuestefeld A, Xie L, McGrew E, Pichet-Binette A, Spotorno N, van Westen D, Mattsson-Carlgren N, Yushkevich PA, Das SR, Wolk DA, Wisse LEM; and for the Alzheimer's Disease Neuroimaging Initiative.: Tau, atrophy, and domain-specific cognitive impairment in typical Alzheimer's disease. Alzheimers Dement 2025.
18c Christopher A Brown; Manuel Taso; Sandhitsu R. Das; Danielle Hing; Emily McGrew; Paul A. Yushkevich; Dawn Mechanic-Hamilton; Ilya M. Nasrallah, MD; David C Alsop; John A. Detre and David A. Wolk: Microstructural and Water Exchange Alterations in ARIA-E in a Real-World Cohort Receiving Anti-Amyloid Therapy. AAIC 2025 2025.
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