Samuel G. Jacobson, MD, PhD
Professor of Ophthalmology
Director, Center for Hereditary Retinal Degenerations and Retinal Function Department
Department: Ophthalmology
Contact information
Scheie Eye Institute
51 North 39th Street
2689
Philadelphia, PA 19104
51 North 39th Street
2689
Philadelphia, PA 19104
Office: 215-662-9981
Fax: 215-662-9388
Fax: 215-662-9388
Email:
jacobsos@mail.med.upenn.edu
jacobsos@mail.med.upenn.edu
Publications
Education:
B.A. (Humanities)
University of Illinois, 1966.
M.D. (Medicine)
University of Illinois, 1970.
Ph.D. (Psychophysics)
University of London, 1977.
B.A. (Humanities)
University of Illinois, 1966.
M.D. (Medicine)
University of Illinois, 1970.
Ph.D. (Psychophysics)
University of London, 1977.
Post-Graduate Training
Intern, Internal Medicine, Rush-Presbyterian St. Luke's Medical Center, Chicago, IL, 1970-1971.
Resident, Rush-Presbyterian St. Luke's Medical Center, Chicago, IL, 1971-1972.
Honorary Clinical Assistant and Doctoral Student, The National Hospital, London, U.K., 1972-1977.
Resident, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, 1977-1980.
Research Affiliate, MIT, Department of Psychology, Cambridge, MA, 1977-1983.
Fellow, Moorfields Eye Hospital, Institute of Ophthalmology and Vision Research, 1980-1982.
Fellow, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, 1982-1983.
Permanent linkIntern, Internal Medicine, Rush-Presbyterian St. Luke's Medical Center, Chicago, IL, 1970-1971.
Resident, Rush-Presbyterian St. Luke's Medical Center, Chicago, IL, 1971-1972.
Honorary Clinical Assistant and Doctoral Student, The National Hospital, London, U.K., 1972-1977.
Resident, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, 1977-1980.
Research Affiliate, MIT, Department of Psychology, Cambridge, MA, 1977-1983.
Fellow, Moorfields Eye Hospital, Institute of Ophthalmology and Vision Research, 1980-1982.
Fellow, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, 1982-1983.
Selected Publications
Jacobson SG., Cideciyan AV., Sumaroka A., Aleman TS., Schwartz SB., Windsor EA., Roman AJ., Stone EM., MacDonald IM.: Remodeling of the human retina in choroideremia: rab escort protein 1 (REP-1) mutations. Investigative Ophthalmology & Visual Science 47(9): 4113-20, Sep 2006.Jacobson SG., Boye SL., Aleman TS., Conlon TJ., Zeiss CJ., Roman AJ., Cideciyan AV., Schwartz SB., Komaromy AM., Doobrajh M., Cheung AY., Sumaroka A., Pearce-Kelling SE., Aguirre GD., Kaushal S., Maguire AM., Flotte TR., Hauswirth WW.: Safety in nonhuman primates of ocular AAV2-RPE65, a candidate treatment for blindness in Leber congenital amaurosis. Human Gene Therapy 17(8): 845-58, Aug 2006.
Williams ML, Coleman JE, Haire SE, Aleman TS, Cideciyan AV, Sokal I, Palczewski K, Jacobson SG, Semple-Rowland SL : Lentiviral expression of retinal guanylate cyclase-1 (RetGC1) restores vision in an avian model of childhood blindness. PLoS Med. 3: e201, Jun 2006.
Jacobson SG, Acland GM, Aguirre GD, Aleman TS, Schwartz SB, Cideciyan AV, et al., Flotte TR, Maguire AM, Bennett JB, Hauswirth WW : Safety of recombinant adeno-asssociated virus type 2-RPE65 vector delivered by ocular subretinal injection. Mol Ther 13: 1074-84, Jun 2006.
Acland GM., Aguirre GD., Bennett J., Aleman TS., Cideciyan AV., Bennicelli J., Dejneka NS., Pearce-Kelling SE., Maguire AM., Palczewski K., Hauswirth WW., Jacobson SG.: Long-term restoration of rod and cone vision by single dose rAAV-mediated gene transfer to the retina in a canine model of childhood blindness. Molecular Therapy: the Journal of the American Society of Gene Therapy 12(6): 1072-82, Dec 2005.
Cideciyan AV., Swider M., Aleman TS., Sumaroka A., Schwartz SB., Roman MI., Milam AH., Bennett J., Stone EM., Jacobson SG.: ABCA4-associated retinal degenerations spare structure and function of the human parapapillary retina. Investigative Ophthalmology & Visual Science 46(12): 4739-46, Dec 2005.
Jacobson SG., Aleman TS., Cideciyan AV., Sumaroka A., Schwartz SB., Windsor EA., Traboulsi EI., Heon E., Pittler SJ., Milam AH., Maguire AM., Palczewski K., Stone EM., Bennett J.: Identifying photoreceptors in blind eyes caused by RPE65 mutations: Prerequisite for human gene therapy success. Proceedings of the National Academy of Sciences of the United States of America 102(17): 6177-82, Apr 26 2005.
Roman AJ., Schwartz SB., Aleman TS., Cideciyan AV., Chico JD., Windsor EA., Gardner LM., Ying GS., Smilko EE., Maguire MG., Jacobson SG.: Quantifying rod photoreceptor-mediated vision in retinal degenerations: dark-adapted thresholds as outcome measures. Experimental Eye Research 80(2): 259-72, Feb 2005.
Cideciyan AV., Jacobson SG., Aleman TS., Gu D., Pearce-Kelling SE., Sumaroka A., Acland GM., Aguirre GD.: In vivo dynamics of retinal injury and repair in the rhodopsin mutant dog model of human retinitis pigmentosa. Proceedings of the National Academy of Sciences of the United States of America 102(14): 5233-8, Apr 5 2005.
Schwartz SB., Aleman TS., Cideciyan AV., Windsor EA., Sumaroka A., Roman AJ., Rane T., Smilko EE., Bennett J., Stone EM., Kimberling WJ., Liu XZ., Jacobson SG.: Disease expression in Usher syndrome caused by VLGR1 gene mutation (USH2C) and comparison with USH2A phenotype. Investigative Ophthalmology & Visual Science 46(2): 734-43, Feb 2005.
Aleman TS, Jacobson SG, Chico JD, Scott ML, Cheung AY, Windsor EA, Furushima M, Redmond TM, Bennett J, Palczewski K, Cideciyan AV: Impairment of the transient pupillary light reflex in Rpe65(-/-) mice and humans with Leber congenital amaurosis. Invest Ophthalmol Vis Sci 45: 1259-1271, 2004.
Wright AF., Jacobson SG., Cideciyan AV., Roman AJ., Shu X., Vlachantoni D., McInnes RR., Riemersma RA.: Lifespan and mitochondrial control of neurodegeneration. [Review] [50 refs] Nature Genetics 36(11): 1153-8, Nov 2004.
Jacobson SG., Cideciyan AV., Aleman TS., Pianta MJ., Sumaroka A., Schwartz SB., Smilko EE., Milam AH., Sheffield VC., Stone EM.: Crumbs homolog 1 (CRB1) mutations result in a thick human retina with abnormal lamination. Human Molecular Genetics 12(9): 1073-8, May 1 2003.
Milam AH., Barakat MR., Gupta N., Rose L., Aleman TS., Pianta MJ., Cideciyan AV., Sheffield VC., Stone EM., Jacobson SG.: Clinicopathologic effects of mutant GUCY2D in Leber congenital amaurosis. Ophthalmology 110(3): 549-58, Mar 2003.
Pianta MJ., Aleman TS., Cideciyan AV., Sunness JS., Li Y., Campochiaro BA., Campochiaro PA., Zack DJ., Stone EM., Jacobson SG.: In vivo micropathology of Best macular dystrophy with optical coherence tomography. Experimental Eye Research 76(2): 203-11, Feb 2003.
Thompson DA, McHenry CL, Li Y, Richards JE, Othman MI, Schwinger E, Vollrath D, Jacobson SG, Gal A: Retinal dystrophy due to parental isodisomy for chromosome 1 or chromosome 2, with homoallelism for mutations in RPE65 or MERTK, respectively. Am J Hum Genet 70: 224-229, 2002.
Jacobson SG., Cideciyan AV., Bennett J., Kingsley RM., Sheffield VC., Stone EM.: Novel mutation in the TIMP3 gene causes Sorsby fundus dystrophy. Archives of Ophthalmology 120(3): 376-9, Mar 2002.
Kijas JW., Cideciyan AV., Aleman TS., Pianta MJ., Pearce-Kelling SE., Miller BJ., Jacobson SG., Aguirre GD., Acland GM.: Naturally occurring rhodopsin mutation in the dog causes retinal dysfunction and degeneration mimicking human dominant retinitis pigmentosa. Proceedings of the National Academy of Sciences of the United States of America 99(9): 6328-33, Apr 30 2002.
Acland GM., Aguirre GD., Ray J., Zhang Q., Aleman TS., Cideciyan AV., Pearce-Kelling SE., Anand V., Zeng Y., Maguire AM., Jacobson SG., Hauswirth WW., Bennett J.: Gene therapy restores vision in a canine model of childhood blindness. Nature Genetics 28(1): 92-5, May 2001.
Aleman TS., LaVail MM., Montemayor R., Ying G., Maguire MM., Laties AM., Jacobson SG., Cideciyan AV.: Augmented rod bipolar cell function in partial receptor loss: an ERG study in P23H rhodopsin transgenic and aging normal rats. Vision Research 41(21): 2779-97, Sep 2001.
Jacobson SG., Cideciyan AV., Wright E., Wright AF.: Phenotypic marker for early disease detection in dominant late-onset retinal degeneration. Investigative Ophthalmology & Visual Science 42(8): 1882-90, Jul 2001.
