University of Pennsylvania Health System

Department of Ophthalmology

Ophthalmology Faculty

Faculty Overview

In Memoriam

Samuel G. Jacobson, MD, PhD

faculty photo
Director, Center for Hereditary Retinal Degenerations, Scheie Eye Institute, University of Pennsylvania
Director, Retinal Function Department,, Scheie Eye Institute, University of Pennsylvania
Department: Ophthalmology

Contact information
Scheie Eye Institute
51 North 39th Street
Philadelphia, PA 19104
B.A. (Humanities)
University of Illinois, 1966.
M.D. (Medicine)
University of Illinois, 1970.
Ph.D. (Psychophysics)
University of London, 1977.
Post-Graduate Training
Intern, Internal Medicine, Rush-Presbyterian St. Luke's Medical Center, Chicago, IL, 1970-1971.
Resident, Rush-Presbyterian St. Luke's Medical Center, Chicago, IL, 1971-1972.
Honorary Clinical Assistant and Doctoral Student, The National Hospital, London, U.K., 1972-1977.
Research Affiliate, MIT, Department of Psychology, Cambridge, MA, 1977-1983.
Resident, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, 1977-1980.
Fellow, Moorfields Eye Hospital, Institute of Ophthalmology and Vision Research, 1980-1982.
Fellow, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, 1982-1983.
Permanent link
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Selected Publications

Moreno-Leon L; West EL; O'Hara-Wright M; Li L; Nair R; He J; Anand M; Sahu B; Chavali VRM; Smith AJ; Ali RR; Jacobson SG; Cideciyan AV; Khanna H : RPGR isoform imbalance causes ciliary defects due to exon ORF15 mutations in X-linked retinitis pigmentosa (XLRP). Human Molecular Genetics 29(22): 3706-3716, Jan 2021.

Semenov EP; Sheplock R; Roman AJ; McGuigan DB; Swider M; Cideciyan AV; Jacobson SG : Reading Performance in Blue Cone Monochromacy: Defining an Outcome Measure for a Clinical Trial. Translational Vision Science & Technology 9(13): 13, Dec 2020.

Song C; Dufour VL; Cideciyan AV; Ye GJ; Swider M; Newmark JA; Timmers AM; Robinson PM; Knop DR; Chulay JD; Jacobson SG; Aguirre GD; Beltran WA; Shearman MS : Dose Range Finding Studies with Two RPGR Transgenes in a Canine Model of X-Linked Retinitis Pigmentosa Treated with Subretinal Gene Therapy. Human Gene Therapy 31(13-14): 743-755, Jul 2020.

Cideciyan AV; Jacobson SG; Roman AJ; Sumaroka A; Wu V; Charng J; Lisi B; Swider M; Aguirre GD; Beltran WA : Rod function deficit in retained photoreceptors of patients with class B Rhodopsin mutations. Scientific Reports 10(1), Jul 2020.

Krishnan AK; Jacobson SG; Roman AJ; Iyer BS; Garafalo AV; Heon E; Cideciyan AV: Transient pupillary light reflex in CEP290- or NPHP5-associated Leber congenital amaurosis: Latency as a potential outcome measure of cone function. Vision Research 168: 53-63, Mar 2020.

Dufour VL; Cideciyan AV; Ye GJ; Song C; Timmers A; Habecker PL; Pan W; Weinstein NM; Swider M; Durham AC; Ying GS; Robinson PM; Jacobson SG; Knop DR; Chulay JD; Shearman MS; Aguirre GD; Beltran WA : Toxicity and Efficacy Evaluation of an Adeno-Associated Virus Vector Expressing Codon-Optimized RPGR Delivered by Subretinal Injection in a Canine Model of X-linked Retinitis Pigmentosa. Human Gene Therapy 31(3-4): 253-267, Feb 2020.

Weisschuh N; Sturm M; Baumann B; Audo I; Ayuso C; Bocquet B; Branham K; Brooks BP; Catala-Mora J; Giorda R; Heckenlively JR; Hufnagel RB; Jacobson SG; Kellner U; Kitsiou-Tzeli S; Matet A; Martorell Sampol L; Meunier I; Rudolph G; Sharon D; Stingl K; Streubel B; Varsanyi B; Wissinger B; Kohl S: Deep-intronic variants in CNGB3 cause achromatopsia by pseudoexon activation. Human Mutation 41(1): 255-264, Jan 2020.

Gardiner KL; Cideciyan AV; Swider M; Dufour VL; Sumaroka A; Komaromy AM; Hauswirth WW; Iwabe S; Jacobson SG; Beltran WA; Aguirre GD : Long-Term Structural Outcomes of Late-Stage RPE65 Gene Therapy. Molecular Therapy: the Journal of the American Society of Gene Therapy 28(1): 266-278, Jan 2020.

Sumaroka A; Cideciyan AV; Sheplock R; Wu V; Kohl S; Wissinger B; Jacobson SG: Foveal Therapy in Blue Cone Monochromacy: Predictions of Visual Potential From Artificial Intelligence. Frontiers in Neuroscience 14, 2020.

Felden J; Baumann B; Ali M; Audo I; Ayuso C; Bocquet B; Casteels I; Garcia-Sandoval B; Jacobson SG; Jurklies B; Kellner U; Kessel L; Lorenz B; McKibbin M; Meunier I; de Ravel T; Rosenberg T; Ruther K; Vadala M; Wissinger B; Stingl K; Kohl S: Mutation spectrum and clinical investigation of achromatopsia patients with mutations in the GNAT2 gene. Human Mutation 40(8): 1145-1155, Aug 2019.

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Last updated: 02/01/2021
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