Kenneth Scott Shindler, MD, PhD
Assistant Professor of Ophthalmology
Department: Ophthalmology
Contact information
Scheie Eye Institute
51 North 39th Street
Philadelphia, PA 19104
51 North 39th Street
Philadelphia, PA 19104
Office: 215-662-8042
Fax: 215-243-4694
Fax: 215-243-4694
Publications
Education
ScB
Brown University, Providence, 1991.
MD, PhD
Washington University, St. Louis, 1999.
ScB
Brown University, Providence, 1991.
MD, PhD
Washington University, St. Louis, 1999.
Post-Graduate Training
Transitional Internship, Presbyterian Medical Center, Philadelphia, PA, 1999-2000.
Ophthalmology Residency, University of Pennsylvania, 2000-2003.
Neuro-Ophthalmology Fellowship, University of Pennsylvania, 2003-2004.
Transitional Internship, Presbyterian Medical Center, Philadelphia, PA, 1999-2000.
Ophthalmology Residency, University of Pennsylvania, 2000-2003.
Neuro-Ophthalmology Fellowship, University of Pennsylvania, 2003-2004.
Certifications
American Board of Ophthalmology, 2005.
Permanent linkAmerican Board of Ophthalmology, 2005.
Description of Research Expertise
Dr. Shindler's research is examing potential mechanisms to provide neuroprotection of retinal ganglion cells in optic neuritis. Optic neuritis is an inflammatory disease of the optic nerve that often occurs as part of the neurodegenerative disease multiple sclerosis. Damage to nerve cells can lead to permanent vision loss in these patients. Dr. Shindler's studies are helping to identify new therapies to prevent nerve damage in this disease, and such therapies will also likely have benefits for other neurodegenerative diseases as well.Keywords
Neuro-ophthalmologic conditions, including optic neuropathies, papilledema, and binocular double vision
Description of Clinical Expertise
Neuro-ophthalmology. Dr. Shindler treats patients with neuro-ophthalmologic conditions, including optic neuropathies, papilledema, and binocular double vision.Selected Publications
Shindler KS, Ventura E, Rex, TS, Elliott P, Rostami A: SIRT1 activation confers neuroprotection in experimental optic neuritis. Invest. Ophthalmol. Vis. Sci. 48(8): 3602-3609, August 2007.Shindler KS, Guan Y, Ventura E, Bennett J, Rostami AM: Retinal ganglion cell loss induced by acute optic neuritis in a relapsing model of multiple sclerosis. Multiple Sclerosis 12: 526-532, 2006.
Guan Y, Shindler KS, Tabuena P, Rostami AM: Retinal ganglion cell damage induced by spontaneous autoimmune optic neuritis in MOG-specific TCR transgenic mice. J. Neuroimmunol. 178(1-2): 40-48, Sept 2006.
Cheng X, Zhao Z, Ventura E, Gran B, Shindler KS, Rostami AM: The PD-1/PD-L pathway is up-regulated during IL-12-induced suppression of EAE mediated by IFN-gamma. J. Neuroimmunol. 185(1-2): 75-86, April 2007.
Shindler KS, Sankar PS, Volpe NJ, Piltz-Seymour JR: Intermittent headaches as the presenting sign of subacute angle-closure glaucoma. Neurology 65(5): 757-758, Sept 2005.
Shindler KS, Liu GT, Womer RB: Long-term follow-up and prognosis of orbital apex syndrome resulting from nasopharyngeal rhabdomyosarcoma. Am. J. Ophthalmol. 140(2): 236-241, Aug 2005.
Shindler KS, Zurakowski D, Dreyer EB: Caspase inhibitors block zinc-chelator induced death of retinal ganglion cells. Neuroreport 11: 2299-302, 2000.
Shindler KS, Yunker AMR, Cahn R, Roth KA: Trophic support promotes survival of bcl-x-deficient telencephalic cells in vitro. Cell Death Diff. 5: 901-910, 1998.
Srinivasan A, Roth KA, Sayers RO, Shindler KS, Wong AM, Fritz LC, Tomaselli KJ: In situ immunodetection of activated caspase-3 in apoptotic neurons in the developing nervous system. Cell Death Diff. 5: 1004-1016, 1998.
Shindler KS, Latham CB, Roth KA: Bax deficiency prevents the increased cell death of immature neurons in bcl-x-deficient mice. J. Neurosci. 17: 3112-3119, 1997.
