Kenneth Scott Shindler, MD, PhD
Assistant Professor of Ophthalmology
Medical Staff Physician, Hospital of the University of Pennsylvania
Medical Staff Physician, Penn Presbyterian Medical Center
Department: Ophthalmology
Contact information
Scheie Eye Institute
51 North 39th Street
Philadelphia, PA 19104
51 North 39th Street
Philadelphia, PA 19104
Office: 215-662-8042
Fax: 215-243-4694
Fax: 215-243-4694
Publications
Education:
ScB (Biochemistry)
Brown University, Providence, 1991.
MD, PhD (Medicine/Neuroscience)
Washington University, St. Louis, 1999.
ScB (Biochemistry)
Brown University, Providence, 1991.
MD, PhD (Medicine/Neuroscience)
Washington University, St. Louis, 1999.
Post-Graduate Training
Transitional Internship, Presbyterian Medical Center, Philadelphia, PA, 1999-2000.
Ophthalmology Residency, University of Pennsylvania, 2000-2003.
Neuro-Ophthalmology Fellowship, University of Pennsylvania, 2003-2004.
Transitional Internship, Presbyterian Medical Center, Philadelphia, PA, 1999-2000.
Ophthalmology Residency, University of Pennsylvania, 2000-2003.
Neuro-Ophthalmology Fellowship, University of Pennsylvania, 2003-2004.
Certifications
American Board of Ophthalmology, 2005.
Permanent linkAmerican Board of Ophthalmology, 2005.
Description of Research Expertise
Dr. Shindler's research is examing potential mechanisms to provide neuroprotection of retinal ganglion cells in optic neuritis. Optic neuritis is an inflammatory disease of the optic nerve that often occurs as part of the neurodegenerative disease multiple sclerosis. Damage to nerve cells can lead to permanent vision loss in these patients. Dr. Shindler's studies are helping to identify new therapies to prevent nerve damage in this disease, and such therapies will also likely have benefits for other neurodegenerative diseases as well.Keywords
Neuro-ophthalmologic conditions, including optic neuropathies, papilledema, and binocular double vision
Description of Clinical Expertise
Neuro-ophthalmology. Dr. Shindler treats patients with neuro-ophthalmologic conditions, including optic neuropathies, papilledema, and binocular double vision.Selected Publications
Das Sarma J, Kenyon LC, Hingley ST, Shindler KS: Mechanisms of primary axonal damage in a viral model of multiple sclerosis J. Neurosci. 29(33): 10272-10280, Aug 2009.Dutt M, Tabuena P, Ventura E, Rostami AM, Shindler KS: Timing of corticosteroid therapy is critical to prevent retinal ganglion cell loss in experimental optic neuritis. Invest. Ophthalmol. Vis. Sci. 2009 Notes: In press.
Shindler KS, Ventura E, Dutt M, Rostami AM: Inflammatory demyelination induces axonal injury and retinal ganglion cell apoptosis in experimental optic neuritis. Exp. Eye Res. 87(3): 208-213, Sept 2008.
Shindler KS, Kenyon LC, Dutt M, Hingley ST, Das Sarma J : Experimental optic neuritis induced by a demyelinating strain of mouse hepatitis virus. J. Virol. 82(17): 8882-8886, Sept 2008.
Shindler KS, Ventura E, Rex, TS, Elliott P, Rostami A: SIRT1 activation confers neuroprotection in experimental optic neuritis. Invest. Ophthalmol. Vis. Sci. 48(8): 3602-3609, August 2007.
Shindler KS, Guan Y, Ventura E, Bennett J, Rostami AM: Retinal ganglion cell loss induced by acute optic neuritis in a relapsing model of multiple sclerosis. Multiple Sclerosis 12: 526-532, 2006.
Guan Y, Shindler KS, Tabuena P, Rostami AM: Retinal ganglion cell damage induced by spontaneous autoimmune optic neuritis in MOG-specific TCR transgenic mice. J. Neuroimmunol. 178(1-2): 40-48, Sept 2006.
Shindler KS, Liu GT, Womer RB: Long-term follow-up and prognosis of orbital apex syndrome resulting from nasopharyngeal rhabdomyosarcoma. Am. J. Ophthalmol. 140(2): 236-241, Aug 2005.
Shindler KS, Sankar PS, Volpe NJ, Piltz-Seymour JR: Intermittent headaches as the presenting sign of subacute angle-closure glaucoma. Neurology 65(5): 757-758, Sept 2005.
Shindler KS, Latham CB, Roth KA: Bax deficiency prevents the increased cell death of immature neurons in bcl-x-deficient mice. J. Neurosci. 17: 3112-3119, 1997.
