5e
4
a4
Ophthalmology Home >
e-
5a
- Faculty f
2
28
60
2
51
16
c
19
1
49
2
13
1b
1d
18
3e
54
1d
2 29
1d
25
Kenneth S. Shindler, M.D., Ph.D.
78
54
F.M. Kirby Professor of Molecular Ophthalmology
28
7a
3
64
Medical Staff Physician, Hospital of the University of Pennsylvania
70
Medical Staff Physician, Penn Presbyterian Medical Center
74
Member, Institute for Translational Medicine and Therapeutics
57
Member, Institute for Immunology
7b
Director, Neuro-Ophthalmology Fellowship, University of Pennsylvania
6a
Faculty Search Advisor, Department of Ophthalmology
11
Department: Ophthalmology
4
1
b
1d
46
Contact information
42
4
3
23
42
Scheie Eye Institute
37 51 North 39th Street
Philadelphia, PA 19104
26
37 51 North 39th Street
Philadelphia, PA 19104
35
f
1f
Graduate Group Affiliations
8
3
1d
-
64
- Neuroscience e
18
Publications
23 a
3
2
29
23 a
Links
115 Search PubMed for articles
d
4
b
1f
115 Search PubMed for articles
d
13
Education:
21 8 ScB 19 (Biochemistry) c
35 Brown University, Providence, 1991.
21 c MD, PhD 22 (Medicine/Neuroscience) c
39 Washington University, St. Louis, 1999.
c
3
3
21
21 8 ScB 19 (Biochemistry) c
35 Brown University, Providence, 1991.
21 c MD, PhD 22 (Medicine/Neuroscience) c
39 Washington University, St. Louis, 1999.
c
1f
Post-Graduate Training
24 64 Transitional Internship, Presbyterian Medical Center, Philadelphia, PA, 1999-2000.
24 51 Ophthalmology Residency, University of Pennsylvania, 2000-2003.
24 58 Neuro-Ophthalmology Fellowship, University of Pennsylvania, 2003-2004.
c
3
25
24 64 Transitional Internship, Presbyterian Medical Center, Philadelphia, PA, 1999-2000.
24 51 Ophthalmology Residency, University of Pennsylvania, 2000-2003.
24 58 Neuro-Ophthalmology Fellowship, University of Pennsylvania, 2003-2004.
c
17
Certifications
28 38 American Board of Ophthalmology, 2005.
c
3
8a
Permanent link28 38 American Board of Ophthalmology, 2005.
c
2 29
21
1e
1d
24
5e
8
17 Keywords
6e Neuro-ophthalmologic conditions, including optic neuropathies, papilledema, and binocular double vision
65
1a 29
27
Description of Research Expertise
232 Dr. Shindler's research is examining potential mechanisms to provide neuroprotection of retinal ganglion cells in optic neuritis. Optic neuritis is an inflammatory disease of the optic nerve that often occurs as part of the neurodegenerative disease multiple sclerosis. Damage to nerve cells can lead to permanent vision loss in these patients. Dr. Shindler's studies are helping to identify new therapies to prevent nerve damage in this disease, and such therapies will also likely have benefits for other neurodegenerative diseases as well.8
17 Keywords
6e Neuro-ophthalmologic conditions, including optic neuropathies, papilledema, and binocular double vision
65
Description of Clinical Expertise
b0 Neuro-ophthalmology. Dr. Shindler treats patients with neuro-ophthalmologic conditions, including optic neuropathies, papilledema, and binocular double vision.1a 29
23
140 Kwok A, Chaqour B, Khan RS, Aravand P, Dine K, Ross AG, Shindler KS: Pharmacological Activation and Transgenic Overexpression of SIRT1 Attenuate Traumatic Optic Neuropathy Induced by Blunt Head Impact. Transl. Vis. Sci. Technol. 13: 27, Sept 2024.
9b Chaqour B, Duong TT, Yue J, Liu T, Camacho D, Dine KE, Esteve-Rudd J, Ellis S, Bennett J, Shindler KS, Ross AG. 65 : AAV2 vector optimization for retinal ganglion cell-targeted delivery of therapeutic genes. 3a Gene Ther. 31: 175-186, Mar 2024.
162 Yue J, Khan RS, Duong TT, Dine KE, Cui QN, O'Neill N, Aravand P, Liu T, Chaqour B, Shindler KS, Ross AG.: Cell-Specific Expression of Human SIRT1 by Gene Therapy Reduces Retinal Ganglion Cell Loss Induced by Elevated Intraocular Pressure. Neurotherapeutics. 20: 896-907, Apr 2023.
83 Shamsher E, Khan RS, Davis BM, Dine K, Luong V, Somavarapu S, Cordeiro MF, Shindler KS. b2 : Nanoparticles Enhance Solubility and Neuroprotective Effects of Resveratrol in Demyelinating Disease. Neurotherapeutics. 20: 1138-1153, Jul 2023.
18b Ross AG, Chaqour B, McDougald DS, Dine KE, Duong TT, Shindler RE, Yue J, Liu T, Shindler KS: Selective Upregulation of SIRT1 Expression in Retinal Ganglion Cells by AAV-Mediated Gene Delivery Increases Neuronal Cell Survival and Alleviates Axon Demyelination Associated with Optic Neuritis. Biomolecules 12: 830, Jun 2022.
110 Saadi F, Chakravarty D, Kumar S, Kamble M, Saha B, Shindler KS, Das Sarma J: CD40L protects against mouse hepatitis virus-induced neuroinflammatory demyelination. PLoS Pathog. 17: e1010059, Dec 2021.
151 McDougald DS, Dine KE, Zezulin AU, Bennett J, Shindler KS: SIRT1 and NRF2 Gene Transfer Mediate Distinct Neuroprotective Effects Upon Retinal Ganglion Cell Survival and Function in Experimental Optic Neuritis. Invest. Ophthalmol. Vis. Sci. 59: 1212-1220, Mar 2018.
129 Grinblat GA, Khan RS, Dine K, Wessel H, Brown L, Shindler KS: RGC Neuroprotection Following Optic Nerve Trauma Mediated By Intranasal Delivery of Amnion Cell Secretome. Invest. Ophthalmol. Vis. Sci. 59: 2470-2477, May 2018.
15e Khan RS, Dine K, Bauman B, Lorentsen M, Lin L, Brown H, Hanson LR, Svitak AL, Wessel H, Brown L, Shindler KS: Intranasal Delivery of A Novel Amnion Cell Secretome Prevents Neuronal Damage and Preserves Function In A Mouse Multiple Sclerosis Model. Sci. Rep. 7: 41768, Jan 2017.
2c
7
1d
1f
Selected Publications
113 Alhadi SA, Camacho D, Chaqour B, Rossman JB, Pham JC, Shindler KS, Ross AG.: Neuroprotective effects of SIRT1 in human RGCs derived from iPSCs following oxidative stress induction at early and late stages of differentiation. 3e Exp. Eye Res. 259: 110526, Oct 2025.140 Kwok A, Chaqour B, Khan RS, Aravand P, Dine K, Ross AG, Shindler KS: Pharmacological Activation and Transgenic Overexpression of SIRT1 Attenuate Traumatic Optic Neuropathy Induced by Blunt Head Impact. Transl. Vis. Sci. Technol. 13: 27, Sept 2024.
9b Chaqour B, Duong TT, Yue J, Liu T, Camacho D, Dine KE, Esteve-Rudd J, Ellis S, Bennett J, Shindler KS, Ross AG. 65 : AAV2 vector optimization for retinal ganglion cell-targeted delivery of therapeutic genes. 3a Gene Ther. 31: 175-186, Mar 2024.
162 Yue J, Khan RS, Duong TT, Dine KE, Cui QN, O'Neill N, Aravand P, Liu T, Chaqour B, Shindler KS, Ross AG.: Cell-Specific Expression of Human SIRT1 by Gene Therapy Reduces Retinal Ganglion Cell Loss Induced by Elevated Intraocular Pressure. Neurotherapeutics. 20: 896-907, Apr 2023.
83 Shamsher E, Khan RS, Davis BM, Dine K, Luong V, Somavarapu S, Cordeiro MF, Shindler KS. b2 : Nanoparticles Enhance Solubility and Neuroprotective Effects of Resveratrol in Demyelinating Disease. Neurotherapeutics. 20: 1138-1153, Jul 2023.
18b Ross AG, Chaqour B, McDougald DS, Dine KE, Duong TT, Shindler RE, Yue J, Liu T, Shindler KS: Selective Upregulation of SIRT1 Expression in Retinal Ganglion Cells by AAV-Mediated Gene Delivery Increases Neuronal Cell Survival and Alleviates Axon Demyelination Associated with Optic Neuritis. Biomolecules 12: 830, Jun 2022.
110 Saadi F, Chakravarty D, Kumar S, Kamble M, Saha B, Shindler KS, Das Sarma J: CD40L protects against mouse hepatitis virus-induced neuroinflammatory demyelination. PLoS Pathog. 17: e1010059, Dec 2021.
151 McDougald DS, Dine KE, Zezulin AU, Bennett J, Shindler KS: SIRT1 and NRF2 Gene Transfer Mediate Distinct Neuroprotective Effects Upon Retinal Ganglion Cell Survival and Function in Experimental Optic Neuritis. Invest. Ophthalmol. Vis. Sci. 59: 1212-1220, Mar 2018.
129 Grinblat GA, Khan RS, Dine K, Wessel H, Brown L, Shindler KS: RGC Neuroprotection Following Optic Nerve Trauma Mediated By Intranasal Delivery of Amnion Cell Secretome. Invest. Ophthalmol. Vis. Sci. 59: 2470-2477, May 2018.
15e Khan RS, Dine K, Bauman B, Lorentsen M, Lin L, Brown H, Hanson LR, Svitak AL, Wessel H, Brown L, Shindler KS: Intranasal Delivery of A Novel Amnion Cell Secretome Prevents Neuronal Damage and Preserves Function In A Mouse Multiple Sclerosis Model. Sci. Rep. 7: 41768, Jan 2017.
2c
