Joan M O'Brien, M.D.
William F. Norris and George E. de Schweinitz Professor of Ophthalmology
Chair, Department of Ophthalmology, Scheie Eye Institute
Department: Ophthalmology
Contact information
University of Pennsylvania
Scheie Eye Institute
Department of Ophthalmology
51 N. 39th Street
Philadelphia, PA 19104
Scheie Eye Institute
Department of Ophthalmology
51 N. 39th Street
Philadelphia, PA 19104
Office: 215-662-8657
Fax: 215-662-9676
Fax: 215-662-9676
Education:
BA (Psychology)
Middlebury College, Middlebury, VT, 1979.
MD
Dartmouth Medical School, Hanover, NH, 1986.
BA (Psychology)
Middlebury College, Middlebury, VT, 1979.
MD
Dartmouth Medical School, Hanover, NH, 1986.
Post-Graduate Training
Postbaccalaureate Premedical Studies, Bryn Mawr College, Bryn Mawr, PA, 1980-1982.
Internal Medicine Internship, Beth Israel Hospital, Boston, MA, 1986-1987.
Clinical Fellow, Internal Medicine, Harvard Medical School, Boston, MA, 1987-1988.
Research Fellow, Internal Medicine (Rheumatology) Harvard Medical School, 1987-1988.
Immunology (Rheumatology and Uveitis), Beth Israel Hospital, Boston, MA, 1987-1988.
Research Fellow, Ophthalmic Pathology, Howe Laboratory, Harvard, Whitehead Institute, Mass Institute of Technology, and Cancer Research Ctr, Mass General Hospital, 1988-1989.
Clinical Fellow, Ophthalmic Pathology, Massachusetts Eye and Ear Infirmary, Boston, MA, 1988-1989.
Clinical Fellow, Ophthalmology, Harvard Medical School, Boston, MA, 1988-1992.
Resident, Ophthalmology Residency, Massachusetts Eye and Ear Infirmary, Boston, MA, 1989-1992.
Ocular Oncology, University of California, San Francisco, 1992-1993.
Postbaccalaureate Premedical Studies, Bryn Mawr College, Bryn Mawr, PA, 1980-1982.
Internal Medicine Internship, Beth Israel Hospital, Boston, MA, 1986-1987.
Clinical Fellow, Internal Medicine, Harvard Medical School, Boston, MA, 1987-1988.
Research Fellow, Internal Medicine (Rheumatology) Harvard Medical School, 1987-1988.
Immunology (Rheumatology and Uveitis), Beth Israel Hospital, Boston, MA, 1987-1988.
Research Fellow, Ophthalmic Pathology, Howe Laboratory, Harvard, Whitehead Institute, Mass Institute of Technology, and Cancer Research Ctr, Mass General Hospital, 1988-1989.
Clinical Fellow, Ophthalmic Pathology, Massachusetts Eye and Ear Infirmary, Boston, MA, 1988-1989.
Clinical Fellow, Ophthalmology, Harvard Medical School, Boston, MA, 1988-1992.
Resident, Ophthalmology Residency, Massachusetts Eye and Ear Infirmary, Boston, MA, 1989-1992.
Ocular Oncology, University of California, San Francisco, 1992-1993.
Certifications
Diplomate, National Board of Medical Examiners, 1987.
Diplomate, American Board of Ophthalmology, 1996.
Permanent linkDiplomate, National Board of Medical Examiners, 1987.
Diplomate, American Board of Ophthalmology, 1996.
Selected Publications
Bejjani A, Choi M, Cassidy L, Collins D, O'Brien J, Murray T, Ksander B, Seigel G.: RB116: An RB+ retioblastoma cell line expressing primitive markers. Molecular Vision 2012 18: 2805-2813, November 2012.Shields C, Ganguly A, O'Brien J, Sato T, Shields J: Uveal Melanoma Trapped in the Temple of Doom. American Journal of Ophthalmology. Elsevier, 154: 219-221, August 2012.
Sachdeva U, O'Brien J: Understanding pRb: toward the necessary development of targeted treatments for retinoblastoma. Journal of Clinical Investigation 122(2): 425-434, February 2012.
McDermott MW, Treseler PA, O'Brien J, Shuman MA, Cha S, Damon LE, Rubenstein J, : Immunochemotherapy with Intensive Consolidation for Primary Central Nervous System Lymphoma: A Pilot Study and Prognostic Assessment by Diffusion-Weighted MRI. Clinical Cancer Research Epub ahead of print, January 2012.
Van Raamsdonk CD, Griewand KG, Crosby MB, Garrido MC, Vemula S, Wiesner T, Obenauf AC, Wackernagel W, Green G, Bouvier N, Sozen MM, Baimukanova G, Roy R, Heguy A, Dolgalev I, Khanin R, Busam K, Speicher MR, O'Brien J, Bastian BC: Mutations in GNA11 in uveal melanoma. N Eng J Med 363(23): 2191-9, Dec 2010.
Kang, SJ, Durairaj, C, Kompella, UB, O'Brien, JM, Grossniklaus, HE.: Subconjunctival nanoparticle carboplatin in the treatment of murine retinoblastoma. Archives of Ophthalmol 127(8): 1043-7, Aug 2009.
Dalgard CL, Gonzalez M, deNiro JE, O'Brien JM.: Differential microRNA-34a expression and tumor suppressor function in retinoblastoma cells. Invest Ophthalmol Vis Sci 50: 4542-51, 2009.
Van Raamsdonk CD, Bezrookove V, Green G, Bauer J, Gaugler L, O'Brien JM, Simpson EM, Barsh GS, Bastian BC.: Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi. Nature 457: 599-602, 2009.
de Alba C, Alejandra G, O'Brien, JM: Poliosis as a manifestation of conjunctival melanoma. Archives of Ophthalmol 126(7): 1006-7, Jul 2008.
Tsai T, O'Brien, JM.: The future promise and the current reality of genetic prognostication in patients with uveal melanoma. Archives of Ophthalmol 126(3): 413-5, Mar 2008.
