University of Pennsylvania Health System

Department of Ophthalmology

Ophthalmology Faculty

Faculty Overview

Joan M O'Brien, M.D.

faculty photo
Harold G. Scheie-Nina C. Mackall Research Professor of Ophthalmology
Chairman, Department of Ophthalmology, University of Pennsylvania
Director, Scheie Eye Institute
Department: Ophthalmology

Contact information
University of Pennsylvania
Scheie Eye Institute
Department of Ophthalmology
51 N. 39th Street
Philadelphia, PA 19104
Graduate Group Affiliations
Education:
BA
Middlebury College, Middlebury, VT, 1979.
MD
Dartmouth Medical School, Hanover, NH, 1986.
Post-Graduate Training
Postbaccalaureate Premedical Studies, Bryn Mawr College, Bryn Mawr, PA, 1980-1982.
Internal Medicine Internship, Beth Israel Hospital, Boston, MA, 1986-1987.
Postdoctoral Fellow in Immunology (Rheumatology and Uveitis), Beth Israel Hospital, Boston, MA, 1987-1988.
Clinical Fellow, Internal Medicine, Harvard Medical School, Boston, MA, 1987-1988.
Research Fellow, Internal Medicine (Rheumatology) , Harvard Medical School, Boston, MA, 1987-1988.
Clinical Fellow Ophthalmic Pathology, Massachusetts Eye and Ear Infirmary, Boston, MA, 1988-1989.
Clinical Fellow Ophthalmology, Harvard Medical School, Boston, MA, 1988-1992.
Research Fellow Ophthalmic Pathology, Howe Laboratory, Harvard, Whitehead Institute, Mass Institute of Technology, and Cancer Research Center, Mass General Hospital, Boston, MA, 1988-1989.
Resident, Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, MA, 1989-1992.
Fellow, Ocular Oncology, Plastics and Orbital Surgery, University of California, San Francisco, CA, 1992-1993.
Certifications
Diplomate, National Board of Medical Examiners, 1987.
Diplomate, American Board of Ophthalmology, 1996.
Diplomate, Re-certification American Board of Ophthalmology, 2006.
Diplomate, Re-certification American Board of Ophthalmology , 2016.
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Description of Clinical Expertise

Dr. O’Brien cares for patients at the Scheie Eye Institute. She specializes in the treatment of ocular tumors, including retinoblastoma, ocular melanoma, conjunctival malignancies, ocular metastases, and ocular and CNS lymphoma.

Description of Research Expertise

Dr. Joan O’Brien has extensive expertise in the study of the genetics of ocular diseases including retinoblastoma, melanoma and glaucoma. Dr. O’Brien’s laboratory has identified numerous unique pathogenic variants in the retinoblastoma gene (RB1). This testing has allowed retinoblastoma therapy to be directed according to underlying genetic risk, and is offered nationwide at no charge to patients through NEI’s eyeGENE™ initiative. Dr. O’Brien directs a research laboratory with next generation sequencing and high-throughput, automated Sanger sequencing capabilities, which focuses on translational genetics research with an emphasis on molecular sub-classification and endophenotyping of ocular disease. Currently, Dr. O’Brien is the primary investigator on an $11.25 million 5-year Primary Open Angle African American Glaucoma Genetics (POAAGG) study.

Clinical Trials
Dr. O’Brien has 15 years of National Cancer Institute funded leadership roles in clinical trials and phenotype validation for all retinoblastoma studies administered through the Children’s Oncology Group (COG). Over the past five years, in collaboration with colleagues at UCSF, the group has discovered and characterized two novel oncogenes (GNAQ, Nature 2009 and GNA11, NEJM 2010) which regulate the MAP kinase pathway. This has allowed Dr. O’Brien’s uveal melanoma patients to have personalized and targeted therapy with MEK inhibitors, providing prolongation of life for these patients with widely metastatic melanoma.

Key Words
retinoblastoma, melanoma, genetics research, glaucoma

Selected Publications

Addis V, Chan L, Chen J, Goodyear K, Pistilli M, Salowe R, Lee R, Sankar P, Miller-Ellis E, Cui Q, Maguire MG, O’Brien JM: Evaluation of the Cirrus HD-OCT Normative Database Probability Codes in an African American Population. Ophthalmology Glaucoma 5(1): 110-118, Jan-Feb 2022.

Brodin AC, Tamhankar MA, Whitehead G, MacKay D, Kim BJ, O'Brien JM: Approach of an Academic Ophthalmology Department to Recovery During the Coronavirus Pandemic. Clinical Ophthalmology 16: 695-704, 2022.

Daniel E, Addis A, Maguire MG, McGeehan B, Chen M, Salowe RJ, Zenebe-Gete S, Meer E, Lee R, Smith E, Gudiseva HV, Sankar PS, O’Brien JM: Prevalence and Factors Associated with Optic Disc Tilt in the Primary Open-Angle African American Glaucoma Genetics (POAAGG) Study. Ophthalmology Glaucoma 2022 Notes: In press.

Alapati T, Sagal KM, Gudiseva HV, Pistilli M, Pyfer M, Chavali VRM, O'Brien JM : Evaluating TNF-α and interleukin-2 (IL-2) as biomarkers for Primary Open-Angle Glaucoma in African Americans. Genes 13: 54, 2022.

Meer E, Nguyen BJ, Tapino PJ, O'Brien JM, Choi D, Addis V: Assessing the Efficacy of 3D-printed Ear Protectors on Mask Adherence at an Academic Ophthalmology Center. Indian Journal of Ophthalmology 70(2): 635-640, Fed 2022.

Addis V, Chen M, Zorger R, Salowe R, Daniel E, Lee R, Pistilli M, Gao J, Maguire MG, Chan L, Gudiseva HV, Zenebe-Gete S, Merriam S, Smith EJ, Martin R, Ostroff CP, Gee JC, Cui QN, Miller-Ellis E, O’Brien JM, Sankar PS: A Precise Method to Evaluate 360 Degree Measures of Optic Cup and Disc Morphology in an African American Cohort and its Genetic Applications. Genes 12(12): 1961, Dec 2021.

Zenebe-Gete S, Salowe R, O’Brien JM: Benefits of Cohort Studies in a Consortia-Dominated Landscape. Frontiers in Genetics 12: 2476, Dec 2021.

Ayala M, Zetterberg M, Skoog I, Zettergren A : Association of Single Nucleotide Polymorphisms Located in LOXL1 with Exfoliation Glaucoma in Southwestern Sweden. Genes. O'Brien, JM (eds.). 12: 1384, Sep 2021 Notes: https://doi.org/10.3390/genes12091384.

Kim CD, Gudiseva HV, McGeehan B, Daniel E, Ying GS, Chavali VRM, O’Brien JM: Association of the SNP rs112369934 near TRIM66 Gene with POAG Endophenotypes in African Americans. Genes 12(9): 1420, Sep 2021 Notes: https://doi.org/10.3390/genes12091420.

Elana Meer, Vivian L Qin, Harini V. Gudiseva, Brendan McGeehan, Rebecca Salowe, Maxwell Pistilli, Jie He, Ebenezer Daniel, Gui-Shuang Ying, Venkata RM Chavali, Joan M O’Brien: LMX1B locus Associated with Low-Risk Baseline Glaucoma-tous Features in the POAAGG Study. Genes 12(8): 1252, Aug 2021.

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Last updated: 06/28/2022
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