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Lachlan James Smith, Ph.D.

Assistant Professor of Neurosurgery
Co-Director, Histology Core, Penn Center for Musculoskeletal Disorders
Department: Neurosurgery

Contact information
424 Stemmler Hall
3450 Hamilton Walk
Philadelphia, PA 19104
Education:
B.E. (Mechatronic Engineering)
University of Adelaide, 2001.
Ph.D. (Pathology)
University of Adelaide, 2008.
Post-Graduate Training
Postdoctoral Fellow in Orthopaedic Surgery, University of Pennsylvania, 2008-2011.
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Description of Research Expertise

The focus of my research program is the pathophysiology and treatment of degenerative and developmental disorders affecting the spine, particularly those affecting the intervertebral discs and vertebral bones. The scope of our research includes basic mechanistic studies, translational studies in animal models, and clinical studies in human patients. We use cutting edge techniques in molecular biology, biochemistry and bioengineering, coupled with novel in vitro model systems to study disease mechanisms. Our research in the translational space bridges the fields of tissue engineering, biomaterials, drug delivery and stem cells, and is focused on arresting disease progression, restoring spine function and potentiating long term tissue regeneration. We use novel, naturally occurring and inducible large and small animal models to study disease etiology and evaluate therapeutics. Our multidisciplinary team includes biologists, bioengineers, clinicians and veterinarians.

Selected Publications

Gullbrand SE, Malhotra NR, Schaer TP, Zawacki Z, Martin JT, Bendigo J, Milby AH, Dodge GR, Vresilovic EJ, Elliott DM, Mauck RL, Smith LJ: A Large Animal Model that Recapitulates the Spectrum of Human Intervertebral Disc Degeneration. Osteoarthritis and Cartilage 25(1): 146-156, Jan 2017.

Tong W, Luc Z, Qin L, Mauck RL, Smith HE, Smith LJ, Malhotra NR, Heyworth MF, Caldera F, Enomoto-Iwamoto M, Zhang Y: Cell Therapy for the Degenerating Intervertebral Disc. Translational Research In press, 2017.

Peck SH, Casal ML, Malhotra NR, Ficicioglu C, Smith LJ: Pathogenesis and Treatment of Spine Disease in the Mucopolysaccharidoses. Molecular Genetics and Metabolism 118(4): 232-243, Aug 2016 Notes: Featured as cover art.

DeLucca JL, Peloquin JM, Smith LJ, Wright AC, Vresilovic EJ, Elliott DM: Endplate Geometry in the Human Spine Using Magnetic Resonance Imaging: Effects of Disc Level, Age, and Degeneration. Journal of Orthopaedic Research 34(8): 1410-1417, Aug 2016.

Gullbrand SE, Ashinsky BG, Martin JT, Pickup S, Smith LJ, Mauck RL, Smith HE: Correlations between Quantitative T2 and T1ρ MRI, Mechanical Properties and Biochemical Composition in a Rabbit Intervertebral Disc Degeneration Model. Journal of Orthopaedic Research 34(8): 1382-1388, Aug 2016.

Simonaro CM, Tomatsu S, Sikora T, Kubaski F, Frohbergh M, Guevara JM, Wang RY, Vera M, Kang JL, Smith LJ, Schuchman EH, Haskins ME: Pentosan Polysulfate: Oral Versus Subcutaneous Injection in Mucopolysaccharidosis Type I Dogs. PLoS One 11(4), April 2016.

Han WM, Heo SJ, White RE, Driscoll TP, Macleod CM, Smith LJ, Duncan RL, Mauck RL, Elliott DM: Microstructural heterogeneity in native and engineered fibrocartilage directs tissue micromechanics and mechanobiology. Nature Materials Page: In Press, Jan 2016.

Martin JT, Gullbrand SE, Ashinsky BG, Kim DH, Ikuta K, Smith LJ, Elliott DM, Mauck RL, Smith HE: Optimization of in vitro pre-culture conditions to maximize in vivo performance of engineered intervertebral discs. 62nd Annual Meeting, Orthopaedic Research Society, Orlando, USA 2016 Notes: Poster.

Gullbrand SE, Ashinsky BG, Martin JT, Pickup S, Smith LJ, Mauck RL, Smith HE: Correlations between Quantitative T2 and T1ρ MRI Parameters and Mechanics and Biochemical Content in a Rabbit Disc Degeneration Model. 62nd Annual Meeting, Orthopaedic Research Society, Orlando, USA 2016 Notes: Podium - presented by trainee (S Gullbrand).

Kim DH, Martin JT, Ikuta K, Smith HE, Elliott DM, Smith LJ, Mauck RL: Variations in Media Formulation Impact ECM Synthesis and Retention in NP Cell-laden HA Hydrogels. 62nd Annual Meeting, Orthopaedic Research Society, Orlando, USA 2016 Notes: Poster.

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Last updated: 03/14/2017
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