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Lachlan James Smith, Ph.D.

Assistant Professor of Neurosurgery
Research Scientist, WOC, Philadelphia VA Medical Center
Co-Director, Histology Core, Penn Center for Musculoskeletal Disorders
Department: Neurosurgery

Contact information
McKay Orthopaedic Research Laboratory
378A Stemmler Hall
3450 Hamilton Walk
Philadelphia, PA 19104
Office: 215-746-2169
Fax: 215-573-2133
B.E. (Mechatronic Engineering)
University of Adelaide, 2001.
Ph.D. (Pathology)
University of Adelaide, 2008.
Post-Graduate Training
Postdoctoral Fellow in Orthopaedic Surgery, University of Pennsylvania, 2008-2011.
Research Associate in Orthopaedic Surgery, University of Pennsylvania, 2011-2013.
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Description of Research Expertise

The focus of my research program is the pathophysiology and treatment of degenerative and developmental disorders affecting the spine, particularly those affecting the intervertebral discs and vertebral bones. The scope of our research includes basic mechanistic studies, translational studies in animal models, and clinical studies in human patients. We use cutting edge techniques in molecular biology, biochemistry and bioengineering, coupled with novel in vitro model systems to study disease mechanisms. Our research in the translational space bridges the fields of tissue engineering, biomaterials, drug delivery and stem cells, and is focused on arresting disease progression, restoring spine function and potentiating long term tissue regeneration. We use novel, naturally occurring and inducible large and small animal models to study disease etiology and evaluate therapeutics. Our multidisciplinary team includes biologists, bioengineers, clinicians and veterinarians.

Selected Publications

Tanpaiboon P, Smith LJ, Casal ML, Chang Y-C, Nampoothiri S, Paiyarom A, Kuptanon C, Trachoo O, Ketudat Cairns JR, Kantaputra PN: Oral Manifestations of Patients and Dogs with Mucopolysaccharidosis Type VII. American Journal of Medical Genetics Part A 179(3): 486-493, Mar 2019.

Pasha S, Smith LJ, Sankar WN: Bone Remodeling and Disc Morphology in the Distal Unfused Spine after Spinal Fusion in Adolescent Idiopathic Scoliosis. Spinal Deformity In press, 2019.

Gullbrand SE, Ashinsky BG, Bonnevie ED, Kim DH, Smith LJ, Elliott DM, Schaer TP, Smith HE, Mauck RL: Evaluation of a Human-Scale Tissue Engineered Intervertebral Disc in a Large Animal Model. 65th Meeting or the Orthopaedic Research Society, Austin, USA 2019.

Zhang C, Peck SH, Bendigo JR, Lau YKA, Malhotra NR, Smith, LJ: Non-Invasive Imaging of Therapeutic Cells Delivered Percutaneously to the Mouse Intervertebral Disc. 65th Annual Meeting, Orthopaedic Research Society, Austin, USA 2019.

Peck SH, Lau YKA, Bendigo JR, Lin M, Arginteanu T, Bagel JH, O'Donnell P, Malhotra NR, Klein PS, Shore EM, Casal ML, Smith LJ: Lithium Treatment Improves Vertebral Trabecular Bone Architecture in Mucopolysaccharidosis I Dogs during Postnatal Growth. 65th Annual Meeting, Orthopaedic Research Society, Austin, USA 2019.

Zhang C, Gullbrand SE, Schaer TP, Elliott DM, Dodge GR, Mayck RN, Malhotra NR, Smith LJ: Inflammatory Cytokine Expression in a Goat Model of Intervertebral Disc Degeneration. 65th Annual Meeting, Orthopaedic Research Society, Austin, USA 2019.

Peck SH, Bendigo JR, Tobias JW, Dodge GR, Malhotra NR, Mauck RL, Smith LJ: Hypoxic preconditioning enhances bone marrow-derived mesenchymal stem cell survival in a low oxygen and nutrient-limited 3D microenvironment. Cartilage In press, 2019.

Piazza M, Peck SH, Gullbrand SE, Bendigo JR, Zhang Y, Smith HE, Malhotra NR, Smith LJ: Quantitative magnetic resonance imaging correlates with histological grade in a percutaneous needle injury mouse model of disc degeneration Journal of Orthopaedic Research 36(10): 2771-2779, Oct 2018 Notes: [EPUB Ahead of Print]

Smith LJ, Silverman L, Sakai D, Le Maitre CL, Mauck RL, Malhotra NR, Lotz JC, Buckley CT: Advancing Cell-based Therapies for Intervertebral Regeneration from the Lab to the Clinic: Recommendations of the ORS Spine Section. JOR Spine In press, Sept 2018.

Malhotra NR, Piazza M, Demoor R, McClintock SD, Hamilton K, Sharma N, Osiemo B, Berger I, Hossain E, Borovskiy Y, Maloney E, Smith LJ, Grady MS: Impact of Reduced Preincision Antibiotic Infusion Time on Surgical Site Infection Rates: A Retrospective Cohort Study. Annals of Surgery Aug 2018 Notes: [Epub Ahead of Print]

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Last updated: 05/06/2019
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