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Lachlan James Smith, Ph.D.

Assistant Professor of Neurosurgery
Research Scientist, WOC, Philadelphia VA Medical Center
Co-Director, Histology Core, Penn Center for Musculoskeletal Disorders
Department: Neurosurgery

Contact information
McKay Orthopaedic Research Laboratory
111A Stemmler Hall
3450 Hamilton Walk
Philadelphia, PA 19104
Office: 215-898-8653
Fax: 215-573-2133
B.E. (Mechatronic Engineering)
University of Adelaide, 2001.
Ph.D. (Pathology)
University of Adelaide, 2008.
Post-Graduate Training
Postdoctoral Fellow in Orthopaedic Surgery, University of Pennsylvania, 2008-2011.
Research Associate in Orthopaedic Surgery, University of Pennsylvania, 2011-2013.
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Description of Research Expertise

The focus of my research program is the pathophysiology and treatment of degenerative and developmental disorders affecting the spine, particularly those affecting the intervertebral discs and vertebral bones. The scope of our research includes basic mechanistic studies, translational studies in animal models, and clinical studies in human patients. We use cutting edge techniques in molecular biology, biochemistry and bioengineering, coupled with novel in vitro model systems to study disease mechanisms. Our research in the translational space bridges the fields of tissue engineering, biomaterials, drug delivery and stem cells, and is focused on arresting disease progression, restoring spine function and potentiating long term tissue regeneration. We use novel, naturally occurring and inducible large and small animal models to study disease etiology and evaluate therapeutics. Our multidisciplinary team includes biologists, bioengineers, clinicians and veterinarians.

Selected Publications

Zhang C, Gullbrand SE, Schaer TP, Elliott DM, Dodge GR, Mayck RN, Malhotra NR, Smith LJ: Inflammatory Cytokine Expression in a Goat Model of Intervertebral Disc Degeneration. 65th Annual Meeting, Orthopaedic Research Society, Austin, USA 2019.

Gullbrand SE, Ashinsky BG, Bonnevie ED, Kim DH, Smith LJ, Elliott DM, Schaer TP, Smith HE, Mauck RL: Evaluation of a Human-Scale Tissue Engineered Intervertebral Disc in a Large Animal Model. 65th Meeting or the Orthopaedic Research Society, Austin, USA 2019.

Zhang C, Peck SH, Bendigo JR, Lau YKA, Malhotra NR, Smith, LJ: Non-Invasive Imaging of Therapeutic Cells Delivered Percutaneously to the Mouse Intervertebral Disc. 65th Annual Meeting, Orthopaedic Research Society, Austin, USA 2019.

Peck SH, Lau YKA, Bendigo JR, Lin M, Arginteanu T, Bagel JH, O'Donnell P, Malhotra NR, Klein PS, Shore EM, Casal ML, Smith LJ: Lithium Treatment Improves Vertebral Trabecular Bone Architecture in Mucopolysaccharidosis I Dogs during Postnatal Growth. 65th Annual Meeting, Orthopaedic Research Society, Austin, USA 2019.

Piazza M, Peck SH, Gullbrand SE, Bendigo JR, Zhang Y, Smith HE, Malhotra NR, Smith LJ: Quantitative magnetic resonance imaging correlates with histological grade in a percutaneous needle injury mouse model of disc degeneration Journal of Orthopaedic Research 36(10): 2771-2779, Oct 2018 Notes: [EPUB Ahead of Print]

Smith LJ, Silverman L, Sakai D, Le Maitre CL, Mauck RL, Malhotra NR, Lotz JC, Buckley CT: Advancing Cell-based Therapies for Intervertebral Regeneration from the Lab to the Clinic: Recommendations of the ORS Spine Section. JOR Spine In press, Sept 2018.

Malhotra NR, Piazza M, Demoor R, McClintock SD, Hamilton K, Sharma N, Osiemo B, Berger I, Hossain E, Borovskiy Y, Maloney E, Smith LJ, Grady MS: Impact of Reduced Preincision Antibiotic Infusion Time on Surgical Site Infection Rates: A Retrospective Cohort Study. Annals of Surgery Aug 2018 Notes: [Epub Ahead of Print]

Riester SM, Lin Y, Wang W, Cong L, Ali AM, Peck SH, Smith LJ, Currier B, Clark M, Huddleston P, Krauss W, Yaszemski MJ, Morrey ME, Abdel MP, Bydon M, Qu W, Larson AN, Wijnen AJ, Nassr A: RNA sequencing identifies gene regulatory networks controlling extracellular matrix synthesis in intervertebral disk tissues. Journal of Orthopaedic Research 36(5): 1356-1369, May 2018.

Piazza M, Sharma N, Osiemo B, McClintock S, Missimer E, Gardiner D, Maloney EM, Callahan D, Smith, LJ, Welch WC, Schuster JM, Grady MS, Malhotra NR: Initial Assessment of the Risk Assessment and Prediction Tool in a Heterogeneous Neurosurgical Population. Neurosurgery May 2018 Notes: [Epub Ahead of Print]

Gullbrand SE, Smith LJ, Smith HE, Mauck RL: Promise, Progress, and Problems in Whole Disc Tissue Engineering. JOR Spine 1(2), May 2018 Notes: Online Only.

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Last updated: 02/13/2019
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