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Devraj Basu, M.D., Ph.D., F.A.C.S.Assistant Professor of Otorhinolaryngology: Head and Neck Surgery at the Hospital of the University of Pennsylvania and the Veteran's Administration Medical Center
Department: Otorhinolaryngology: Head and Neck Surgery
Contact information
5 Ravdin/Silverstein
Hospital of the University of Pennsylvania 3400 Spruce Street Philadelphia, PA 19104
Education:
Sc.B (Biology) Brown University, 1994. Ph.D. (Immunology) Washington University School of Medicine, 2001. M.D. (Medicine) Washington University School of Medicine, 2001.
Post-Graduate Training
Intern, Surgery, Barnes-Jewish Hospital, 2001-2002. Resident, Otolaryngology, Barnes-Jewish Hospital, 2002-2005. Chief Resident, Otolaryngology, Barnes-Jewish Hospital, 2005-2006. Fellow, Head and Neck Surgery and Microvascular Reconstruction, Hospital of the University of Pennsylvania, 2006-2007.
Certifications
Permanent linkAmerican Board of Otolaryngology, 2007. Description of Research ExpertiseSquamous cell carcinoma biology3-dimensional in vitro cancer models Tumor heterogeneity Epithelial to mesenchymal transition Tumor cell quiescence Description of Clinical ExpertiseSurgical treatment of disorders of the head and neckBenign and malignant tumors of the head and neck Oral Cancer Laryngeal Cancer Salivary Cancer Sinonasal Cancer Skin Cancer Thyroid and parathyroid surgery Transoral laser surgery Head and neck trauma Endoscopic sinus surgery Selected PublicationsBasu D, Ngyen TK, Montone KT, Zhang BS, Wang L, Diehl JA, Rustgi AK, Lee JT, Weinstein GS, Herlyn M: Evidence for mesenchymal-like subpopulations within squamous cell carcinomas possessing chemoresistance and phenotypic plasticity. Oncogene 29(29): 4170-4182, July 2010.Basu D, Montone KT, Wang LP, Gimotty PA, Hammond R, Diehl JA, Rustgi AK, Lee JT, Rasanen K, Weinstein GS, Herlyn M. : Detecting and targeting mesenchymal-like subpopulations within squamous cell carcinomas. Cell Cycle 10(12): 2008-2016, June 2011. Ohashi S, Natsuizaka M, Naganuma S, Kagawa S, Kimura S, Itoh H, Kalman RA, Nakagawa M, Darling DS, Basu D, Gimotty PA, Klein-Szanto AJ, Diehl JA, Herlyn M, Nakagawa H.: A NOTCH3-mediated squamous cell differentiation program limits expansion of EMT competent cells that express the ZEB transcription factors. Cancer Research 71(21): 6836-47, November 2011. Roesch A,Fukunaga-Kalabis M, Schmidt EC, Zabierowski SE, Brafford PA, Vultur A, Basu D, Gimotty P, Vogt T,4 Herlyn M: A Temporarily Distinct Subpopulation of Slow-Cycling Melanoma Cells Is Required for Continuous Tumor Growth. Cell 141(4): 583-594, May 2010. Basu D, Herlyn M: Commentary: defining microenvironments within mouse models that enhance tumor aggressiveness. Cancer Biol Ther 8(4): 380-1, February 2009. Rasanen K, Herlyn M, Rustgi A, Basu D : Modeling the Crosstalk Between Head and Neck Carcinoma Cells and Stromal Fibroblasts that Drives Malignant Invasion American Head and Neck Society Research Workshop on the Biology, Prevention, and Treatment of Head and Neck Cancer (poster) October 2010. Basu D, Siegel BA, McDonald DJ, Nussenbaum B: Detection of occult bone metastasis from head and neck squamous cell carcinoma: impact of PET/CT imaging. Arch Otolaryngol Head Neck Surg 133(8): 801 - 805, August 2007. Basu D, Horvath S, O’Mara L, Donermeyer D, Allen PM: Two MHC surface amino acid differences distinguish foreign peptide recognition from autoantigen specificity. J. Immunol 166(6): 4005 - 4011, March 2001. Basu D, Horvath S, Matsumoto I, Fremont DH, Allen PM. : Molecular basis for recognition of an arthritic peptide and a foreign epitope on distinct MHC molecules by as single TCR. J. Immunol 164(11): 5788 - 5796, June 2000. Basu D, Williams CB, Allen PM. : In vivo antagonism of a T cell response by an endogenous ligand. Proc. Natl. Acad. Sci. 95(24): 14332 -14336, November 1998.
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