Department of Otorhinolaryngology

faculty photo

Devraj Basu, M.D., Ph.D., F.A.C.S.

Assistant Professor of Otorhinolaryngology: Head and Neck Surgery at the Hospital of the University of Pennsylvania and the Veteran's Administration Medical Center
Full Member, Abramson Cancer Center
Department: Otorhinolaryngology: Head and Neck Surgery

Contact information
5 Ravdin/Silverstein
Hospital of the University of Pennsylvania
3400 Spruce Street
Philadelphia, PA 19104
Sc.B (Biology)
Brown University, 1994.
Ph.D. (Immunology)
Washington University School of Medicine, 2001.
M.D. (Medicine)
Washington University School of Medicine, 2001.
Post-Graduate Training
Intern, Surgery, Barnes-Jewish Hospital, 2001-2002.
Resident, Otolaryngology, Barnes-Jewish Hospital, 2002-2005.
Chief Resident, Otolaryngology, Barnes-Jewish Hospital, 2005-2006.
Fellow, Head and Neck Surgery and Microvascular Reconstruction, Hospital of the University of Pennsylvania, 2006-2007.
American Board of Otolaryngology, 2007.
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Description of Research Expertise

I lead a laboratory whose overall focus is on the mechanisms by which subpopulations of tumor cells within head and neck cancers evade therapy. Our work has pursued how stem cell-like subpopulations with mesenchymal differentiation resist anti-EGFR therapy via both tumor cell-autonomous mechanisms and crosstalk with stromal cells. We have recently sought more precise molecular definition of cancer stem cells within oral cancers as well as detailed understanding of mechanisms involved in regulating their homeostasis. By defining mechanisms responsible for replenishing such cells after their targeted depletion, we are seeking to establish novel approaches for durable cancer stem cell eradication. In the process, we have developed the expertise and infrastructure for analyzing stem cell-like subpopulations within cell lines, patient-derived xenografts, and primary human oral cancer samples based on molecular and functional criteria. We are using lentiviral cDNA and shRNA vectors to investigate the functional crosstalk among genes and signaling pathways involved in cancer stem cell maintenance.

Description of Clinical Expertise

Surgical treatment of disorders of the head and neck
Benign and malignant tumors of the head and neck
Oral Cancer
Laryngeal Cancer
Salivary Cancer
Sinonasal Cancer
Skin Cancer
Thyroid and parathyroid surgery
Transoral laser surgery
Head and neck trauma
Endoscopic sinus surgery

Selected Publications

Basu D, Bewley AF, Sperry SM, Montone KT, Gimotty PA, Rasanen K, Facompre ND, Weinstein GS, Nakagawa H, Diehl JA, Rustgi AK, Herlyn M : EGFR Inhibition Promotes an Aggressive Invasion Pattern Mediated by Mesenchymal-like Tumor Cells within Squamous Cell Carcinomas. Mol. Cancer Ther. 12(10): 2176-87, October 2013.

Facompre N, Nakagawa H, Herlyn M, Basu D: Stem-like cells and therapy resistance in squamous cell carcinomas. Adv. Pharmacol. 65: 235-265, October 2012.

Basu D, Montone KT, Wang LP, Gimotty PA, Hammond R, Diehl JA, Rustgi AK, Lee JT, Rasanen K, Weinstein GS, Herlyn M. : Detecting and targeting mesenchymal-like subpopulations within squamous cell carcinomas. Cell Cycle 10(12): 2008-2016, June 2011.

Basu D, Ngyen TK, Montone KT, Zhang BS, Wang L, Diehl JA, Rustgi AK, Lee JT, Weinstein GS, Herlyn M: Evidence for mesenchymal-like subpopulations within squamous cell carcinomas possessing chemoresistance and phenotypic plasticity. Oncogene 29(29): 4170-4182, July 2010.

Roesch A,Fukunaga-Kalabis M, Schmidt EC, Zabierowski SE, Brafford PA, Vultur A, Basu D, Gimotty P, Vogt T,4 Herlyn M: A Temporarily Distinct Subpopulation of Slow-Cycling Melanoma Cells Is Required for Continuous Tumor Growth. Cell 141(4): 583-594, May 2010.

Ohashi S, Natsuizaka M, Naganuma S, Kagawa S, Kimura S, Itoh H, Kalman RA, Nakagawa M, Darling DS, Basu D, Gimotty PA, Klein-Szanto AJ, Diehl JA, Herlyn M, Nakagawa H.: A NOTCH3-mediated squamous cell differentiation program limits expansion of EMT competent cells that express the ZEB transcription factors. Cancer Research 71(21): 6836-47, November 2011.

Rasanen K, Sriswasdi S, Valiga A, Tang HY, Zhang G, Perego M, Somasundaram R, Li L, Speicher K, Klein-Szanto A, Basu D, Rustgi AK, Speicher DW, Herlyn M.: Comparative secretome analysis of epithelial and mesenchymal subpopulations of head and neck squamous cell carcinoma identifies S100A4 as a potential therapeutic target. Mol Cell Proteomics 12(12): 3778-92, December 2013.

Basu D, Herlyn M: Commentary: defining microenvironments within mouse models that enhance tumor aggressiveness. Cancer Biol Ther 8(4): 380-1, February 2009.

Basu D, Herlyn M: Commentary: Salmonella typhimurium as a novel RNA interference vector for cancer gene therapy. Cancer Biol Ther 7(1): 151-152, January 2008.

Basu D, Siegel BA, McDonald DJ, Nussenbaum B: Detection of occult bone metastasis from head and neck squamous cell carcinoma: impact of PET/CT imaging. Arch Otolaryngol Head Neck Surg 133(8): 801 - 805, August 2007.

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Last updated: 09/18/2016
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