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Gregory P Bisson, MD, MSCE

Assistant Professor of Medicine
Attending Physician, Infectious Diseases Division, Department of Medicine, Philadelphia Veterans Affairs Medical Center
Senior Scholar, Department of Biostatistics and Epidemiology, University of Pennsylvania Perelman School of Medicine
Department: Medicine

Contact information
832 Blockley Hall
423 Guardian Drive
Center for Clinical Epidemiology and Biostatistics
University of Pennsylvania
Philadelphia, PA 19104-6021
Office: 215-573-5811
Fax: 215-573-5315
Graduate Group Affiliations
BA (Japanese)
University of Wisconsin-Madison, 1992.
University of Minnesota School of Medicine, 1997.
University of Pennsylvania School of Medicine, Epidemiology, 2006.
Post-Graduate Training
Intern , Department of Medicine, University of Pennsylvania School of Medicine, 1997-1998.
Resident , Department of Medicine, University of Pennsylvania School of Medicine, 1998-2000.
Fellow, Division of Infectious Diseases, Department of Medicine, University of Pennsylvania School of Medicine, 2000-2003.
Fellow, Pharmacoepidemiology, Division of Epidemiology, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, 2001-2003.
American Board of Internal Medicine, Internal Medicine, 2000.
American Board of Internal Medicine, Infectious Diseases, 2002.
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Description of Research Expertise

My research is dedicated to improving treatment outcomes of patients with HIV and tuberculosis (TB) and other AIDS-associated opportunistic infections. Current research projects are evaluating the relationship between very early virologic and immunologic response to antiretroviral therapy and clinical outcomes in adults with HIV/TB or HIV and Cryptococcal meningitis. Many patients with advanced HIV die soon after antiretroviral therapy initiation, and our research group focuses on trying to understand the pathophysiologic and social mechanisms underlying these early deaths. In addition, we are pursuing translational projects evaluating the epidemiology and molecular epidemiology of drug resistant TB.

Selected Publications

Ravimohan, S: Early Immunologic Responses Distinguish Early Mortality and Immune Reconstitution Inflammatory Syndrome in Advanced HIV/Tuberculosis Co-infected Adults Initiating Antiretroviral Therapy. 20th International AIDS Conference, Melbourne, Australis July 2014.

Shruthi Ravimohan, Neo Tamuhla, Andrew P. Steenhoff, Rona Letlhogile, Kebatshabile Nfanyana, Didi Malang Makutu, Tumelo Rantleru, Robert Gross, Drew Weissman, Gregory P. Bisson : Depleted DHEA-S reserves are associated with early mortality after ART initiation in HIV/TB co-infected patients in Botswana 20th Conference on Retroviruses and Opportunistic Infections, Boston Ma 827, March 2014.

Nicola M. Zetola1, Chawangwa Modongo, Patrick K. Moonan, Ronald Ncube, Keikantse Matlhagela, Enoch Sepako, Ronald G. Collman, Gregory P. Bisson : Clinical outcomes among persons with pulmonary tuberculosis disease caused by M. tuberculosis isolates with phenotypic DST heterogeneity Journal of Infectious Diseases January 2014.

Ravimohan S, Tamuhla N, Steenhoff AP, Letlhogile R, Makutu DK, Nfanyanan K, Rantleru T, Tierney A, Nkakana K, Schwartz AB, Gross R, MacGregor RR, Bellamy S, Frank I, Weissman D, Bisson GP: Early Immunologic Failure is Associated with Early Mortality Among Advanced HIV-Infected Adults Initiating ART with Active Tuberculosis Journal of Infectious Diseases 208(11): 1784-93, Dec 2013 Notes: Epub ahead of print.

Schwartz AB, Tamuhla N, Steenhoff AP, Nkakana K, Letlhogile R, Chadborn TR, Kestler M, Zetola N, Ravimohan S, Bisson GP: Outcomes in HIV-infected Adults with Tuberculosis at Clinics with and without co-located HIV Clinics in Botswana. International Journal of Tuberculosis and Lung Disease 17(10): 1298-303, October 2013.

Auld SC, Click ES, Heilig CM, Miramontes R, Cain KP, Bisson GP, Mac Kenzie WR: Association between tuberculin skin test result and clinical presentation of tuberculosis disease. BMC Infectious Diseases 13(1): 460, October 2013 Notes: Epub ahead of print.

Puryear S, Seropola G, Ho-Foster A, Arscott-Mills T, Mazhani L, Firth J, Goldfarb DM, Ncube R, Bisson GP, Steenhoff AP: Yield of contact tracing from pediatric tuberculosis index cases in Gaborone, Botswana. International Journal of Tuberculosis and Lung Disease 17(8): 1049-55, Aug 2013.

Bisson GP, Molefi M, Bellamy S, Thakur R, Steenhoff A, Tamuhla N, Rantleru T, Tsimako I, Gluckman S, Ravimohan S, Weissman D, Tebas P: Early versus delayed antiretroviral therapy and cerebospinal fluid fungal clearance in adults with HIV and cryptococcal meningitis. Clinical Infectious Diseases 56(8): 1165-73, April 2013.

Hafkin J, Modongo C, Newcomb C, Lowenthal E, Macgregor RR, Steenhoff AP, Friedman HM, Bisson GP: Impact of the human immunodeficiency virus on early multidrug-resistant tuberculosis treatment outcomes in Botswana. International Journal of Tuberculosis and Lung Disease 17(3): 348-53, March 2013.

Vinnard C, Wileyto EP, Bisson GP, Winston CA: First Use of Multiple Imputation with the National Tuberculosis Surveillance System. Epidemiology Research International 18: pii:875234, December 2012.

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Last updated: 04/14/2014
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