My research is dedicated to improving treatment outcomes of patients with HIV and tuberculosis (TB) and other AIDS-associated opportunistic infections. Current research projects are evaluating the relationship between very early virologic and immunologic response to antiretroviral therapy and clinical outcomes in adults with HIV/TB or HIV and Cryptococcal meningitis. Many patients with advanced HIV die soon after antiretroviral therapy initiation, and our research group focuses on trying to understand the pathophysiologic and social mechanisms underlying these early deaths. In addition, we are pursuing translational projects evaluating the epidemiology and molecular epidemiology of drug resistant TB.
Selected Publications
Bisson GP, Molefi M, Bellamy S, Thakur R, Steenhoff A, Tamuhla N, Rantleru T, Tsimako I, Gluckman S, Ravimohan S, Weissman D, Tebas P: Early versus delayed antiretroviral therapy and CSF fungal clearance in adults with HIV and cryptococcal meningitis. Clinical Infectious Diseases 56(8): 1165-73, April 2013.
Hafkin J, Modongo C, Newcomb C, Lowenthal E, Macgregor RR, Steenhoff AP, Friedman H, Bisson, GP: Impact of the human immunodeficiency virus on early multidrug-resistant tuberculosis treatment outcomes in Botswana. International Journal of Tuberculosis and Lung Disease(3), 348-53, March 2013.
Vinnard C, Wileyto P, Bisson GP, Winston C: First Use of Multiple Imputation with the National Tuberculosis Surveillance System. Epidemiology Research International December 2012.
Bisson G, Mehaffy C, Broeckling C, Prenni J, Rifat D, Lun D, Burgos M, Weissman D, Karakousis P, Dobos K: Upregulation of the phthiocerol dimycocerosate biosynthetic pathway by rifampicin-resistant, rpoB-mutant Mycobacterium tuberculosis. Journal of Bacteriology 194(23): 6441-52, December 2012.
Zetola N, Modongo C, Kip E, Gross R, Bisson GP, Collman R
: Alcohol use and abuse among patients with multi-drug resistant tuberculosis in Botswana. International Journal of Tuberculosis and Lung Disease(11), 1529-34, November 2012.
Puryear S, Seropola G, Ho-Foster A, Arscott-Mills T, Mazhani L, Ncube R, Bisson GP, Steenhoff AP: Yield of contact tracing among household contacts of children diagnosed with TB in Gaborone, Botswana. Poster Presentation PC-636-17 at the 43rd Union World Conference on Lung Health, Kuala Lumpur, Malaysia November 2012.
Han J, Crane H, Bellamy S, FRANK I, Cardillo S, Bisson GP : HIV Infection and Glycemic Response to Newly Initiated Diabetic Medical Therapy. AIDS 26(16): 2087-2095, October 2012.
Steenhoff AP, Redwood A, Pettifor JM, Hove J, Bisson GP, Mosepele M,
Pusoesele P, Thakur R, Kovarik C, Gross R
: Vitamin D Status in HIV Infected Patients with and without Tuberculosis: A Pilot Study
JAIDS 61(2): 21-3, October 2012.
Schwartz A, Tamuhla N, Steenhoff A, Nkakana K, Letlhogile R, Chadborn T, Bisson GP: Outcomes among HIV-infected adults with active pulmonary TB treated in clinics with and without on-site HIV clinics in Botswana: a retrospective cohort study. Poster Presentation #928 at the 19th Conference on Retroviruses and Opportunistic Infections (CROI), Seattle, Washington 2012.
Han J, Crane H, Bellamy S, Frank I, Cardillo S, Bisson GP: HIV Infection and Glycemic Response to Initial Diabetic Medical Therapy Poster Presentation #852 at the 19th Conference on Retroviruses and Opportunistic Infections (CROI), Seattle, Washington 2012.
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Last updated: 05/07/2013
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