My research is dedicated to improving treatment outcomes of patients with HIV and tuberculosis (TB) and other AIDS-associated opportunistic infections. Current research projects are evaluating the relationship between very early virologic and immunologic response to antiretroviral therapy and clinical outcomes in adults with HIV/TB or HIV and Cryptococcal meningitis. Many patients with advanced HIV die soon after antiretroviral therapy initiation, and our research group focuses on trying to understand the pathophysiologic and social mechanisms underlying these early deaths. In addition, we are pursuing translational projects evaluating the epidemiology and molecular epidemiology of drug resistant TB.
Ravimohan S, Tamuhla N, Steenhoff AP, Letlhogile R, Nfanyanam K, Bellamy S, MacGregor RR, Gross R, Weissman D, Bisson GP: Immunological profiling of tuberculosis-associated immune reconstitution inflammatory syndrome and non-immune reconstitution inflammatory syndrome death in HIV-infected adults with pulmonary tuberculosis starting antiretroviral therapy: a prospective observational cohort study. The Lancet Infectious Diseases 15(4): 429-438, April 2015.
Bisson GP, Zetola N, Collman R: Persistent High Mortality in Advanced HIV/TB Despite Appropriate Antiretroviral and Antitubercular Therapy: An Emerging Challenge. Current HIV/AIDS Reports 12(1): 107-116, March 2015.
Zetola NM, Modongo C, Moonan PK, Ncube R, Matlhagela K, Sepako E, Collman RG, Bisson GP: Clinical outcomes among persons with pulmonary tuberculosis disease caused by M. tuberculosis isolates with phenotypic DST heterogeneity Journal of Infectious Diseases
209(11): 1754-63, June 2014.
Ravimohan S, Tamuhla N, Steenhoff AP, Letlhogile R, Makutu DK, Nfanyanan K, Rantleru T, Tierney A, Nkakana K, Schwartz AB, Gross R, MacGregor RR, Bellamy S, Frank I, Weissman D, Bisson GP: Early Immunologic Failure is Associated with Early Mortality Among Advanced HIV-Infected Adults Initiating ART with Active Tuberculosis
Journal of Infectious Diseases 208(11): 1784-93, Dec 2013 Notes: Epub ahead of print.
Bisson GP, Molefi M, Bellamy S, Thakur R, Steenhoff A, Tamuhla N, Rantleru T, Tsimako I, Gluckman S, Ravimohan S, Weissman D, Tebas P: Early versus delayed antiretroviral therapy and cerebospinal fluid fungal clearance in adults with HIV and cryptococcal meningitis. Clinical Infectious Diseases 56(8): 1165-73, April 2013.
Hafkin J, Modongo C, Newcomb C, Lowenthal E, Macgregor RR, Steenhoff AP, Friedman HM, Bisson GP: Impact of the human immunodeficiency virus on early multidrug-resistant tuberculosis treatment outcomes in Botswana. International Journal of Tuberculosis and Lung Disease 17(3): 348-53, March 2013.
Schwartz AB, Tamuhla N, Steenhoff AP, Nkakana K, Letlhogile R, Chadborn TR, Kestler M, Zetola N, Ravimohan S, Bisson GP: Outcomes in HIV-infected Adults with Tuberculosis at Clinics with and without co-located HIV Clinics in Botswana. International Journal of Tuberculosis and Lung Disease 17(10): 1298-303, October 2013.
Bisson GP, Mehaffy C, Broeckling C, Prenni J, Rifat D, Lun D, Burgos M, Weissman D, Karakousis PC, Dobos K: Upregulation of the phthiocerol dimycocerosate biosynthetic pathway by rifampicin-resistant, rpoB-mutant Mycobacterium tuberculosis. Journal of Bacteriology 194(23): 6441-52, December 2012.
Vinnard C, Winston CA, Wileyto EP, MacGregor RR, Bisson GP: Isoniazid Resistance and Death in Patients with Tuberculous Meningitis: Retrospective Cohort Study. British Medical Journal 17(3): 341:c4451, September 2010.
Bisson GP, Gross R, Bellamy S, Rollins C, Chittams J, Frank I, Maartens G, Nachega J
: Pharmacy Refill Assessment Compared With CD4 Count Monitoring for Predicting Virologic Failure Among HIV-Infected Patients on Highly Active Antiretroviral Therapy. PLoS Medicine 5(5), May 2008.
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Last updated: 05/12/2015
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