My research is dedicated to improving treatment outcomes of patients with HIV and tuberculosis (TB) and other AIDS-associated opportunistic infections. Current research projects are evaluating the relationship between very early virologic and immunologic response to antiretroviral therapy and clinical outcomes in adults with HIV/TB or HIV and Cryptococcal meningitis. Many patients with advanced HIV die soon after antiretroviral therapy initiation, and our research group focuses on trying to understand the pathophysiologic and social mechanisms underlying these early deaths. In addition, we are pursuing translational projects evaluating the epidemiology and molecular epidemiology of drug resistant TB.
Ravimohan S, Tamuhla N, Steenhoff AP, Letlhogile R, Nfanyanam K, Bellamy S, MacGregor RR, Gross R, Weissman D, Bisson GP: Immunological profiling of tuberculosis-associated immune reconstitution inflammatory syndrome and non-immune reconstitution inflammatory syndrome death in HIV-infected adults with pulmonary tuberculosis starting antiretroviral therapy: a prospective observational cohort study. The Lancet Infectious Diseases February 2015.
Bisson GP, Zetola N, Collman R: Persistent High Mortality in Advanced HIV/TB Despite Appropriate Antiretroviral and Antitubercular Therapy: An Emerging Challenge. Current HIV/AIDS Reports In press, 2015.
Ravimohan S, Tamuhla N, Steenhoff AP, Letlhogile R, Nfanyana K, Rantleru T, Gross R, Weissman D, Bisson GP: Pre-ART Immunologic Profiles Characterize Risk of Early Mortality and TB-IRIS in HIV/TB Co-infected Adults. ICAAC 54th Interscience Conference on Antimicrobial Agents and Chemotherapy H-1199b, September 2014 Notes: Late breaker oral abstract.
Khensouvann L, Kutzler M, Gumbo T, Pasipanodya J, Schlecht H, Bisson GP, Peloquin C, Vinnard C: Urine Colorimetry to Detect Low Rifampicin Bioavailability: A Proof-of-Concept Study. ICAAC 54th Interscience Conference on Antimicrobial Agents and Chemotherapy September 2014 Notes: Poster Presentation.
Zentner I, Khensouvann L, Kutzler M, Schlecht H, Bisson GP, Peloquin C, Vinnard C: A Urine Colorimetric Assay to Detect Low Peak Serum Concentrations of Pyrazinamide: A Proof-of-Concept Study
ICAAC 54th Interscience Conference on Antimicrobial Agents and Chemotherapy September 2014 Notes: Poster Presentation.
Ravimohan S, Bisson GP: Early Immunologic Responses Distinguish Early Mortality and Immune Reconstitution Inflammatory Syndrome in Advanced HIV/Tuberculosis Co-infected Adults Initiating Antiretroviral Therapy. 20th International AIDS Conference, Melbourne, Australia July 2014.
Zetola NM, Modongo C, Moonan PK, Ncube R, Matlhagela K, Sepako E, Collman RG, Bisson GP: Clinical outcomes among persons with pulmonary tuberculosis disease caused by M. tuberculosis isolates with phenotypic DST heterogeneity Journal of Infectious Diseases
209(11): 1754-63, June 2014.
Ravimohan S, Tamuhla N, Steenhoff AP, Letlhogile R, Nfanyana K, Makutu DM, Rantleru T, Gross R, Weissman D, Bisson GP
: Depleted DHEA-S reserves are associated with early mortality after ART initiation in HIV/TB co-infected patients in Botswana
20th Conference on Retroviruses and Opportunistic Infections, Boston MA 827, March 2014.
Bearden D, Steenhoff A, Dlugos D, Kolson D, Mehta P, Kessler S, Lowenthal E, Monokwane B, Anabwani G, Bisson GP: Early Antiretroviral Therapy is Protective against Epilepsy in Children with Human Immunodeficiency Virus Infection in Botswana. JAIDS 2014.
Ravimohan S, Tamuhla N, Steenhoff AP, Letlhogile R, Makutu DK, Nfanyanan K, Rantleru T, Tierney A, Nkakana K, Schwartz AB, Gross R, MacGregor RR, Bellamy S, Frank I, Weissman D, Bisson GP: Early Immunologic Failure is Associated with Early Mortality Among Advanced HIV-Infected Adults Initiating ART with Active Tuberculosis
Journal of Infectious Diseases 208(11): 1784-93, Dec 2013 Notes: Epub ahead of print.
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Last updated: 03/02/2015
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