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Gregory P Bisson, MD, MSCE

Assistant Professor of Medicine
Attending Physician, Philadelphia Veterans Affairs Medical Center
Senior Scholar, Department of Biostatistics and Epidemiology, Perelman School of Medicine
Department: Medicine

Contact information
832 Blockley Hall
423 Guardian Drive
Center for Clinical Epidemiology and Biostatistics
University of Pennsylvania
Philadelphia, PA 19104-6021
Office: 215-573-5811
Fax: 215-573-5315
BA (Japanese)
University of Wisconsin-Madison, 1992.
University of Minnesota School of Medicine, 1997.
MSCE (Epidemiology)
Perelman School of Medicine, University of Pennsylvania, 2006.
Post-Graduate Training
Intern , Department of Medicine, School of Medicine, University of Pennsylvania, 1997-1998.
Resident , Department of Medicine, School of Medicine, University of Pennsylvania, 1998-2000.
Fellow, Division of Infectious Diseases, Department of Medicine, School of Medicine, University of Pennsylvania, 2000-2003.
Fellow, Pharmacoepidemiology, Division of Epidemiology, Department of Biostatistics and Epidemiology, School of Medicine, University of Pennsylvania, 2001-2003.
American Board of Internal Medicine, Internal Medicine, 2000.
American Board of Internal Medicine, Infectious Diseases, 2015.
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Description of Research Expertise

My research is dedicated to improving treatment outcomes of patients with HIV and tuberculosis (TB) and other AIDS-associated opportunistic infections. Current research projects are evaluating the relationship between very early virologic and immunologic response to antiretroviral therapy and clinical outcomes in adults with HIV/TB. Many patients with advanced HIV die soon after antiretroviral therapy initiation, and our research group focuses on trying to understand the pathophysiologic and social mechanisms underlying these early deaths. In addition, we are pursuing translational projects evaluating novel host-directed therapies for treatment of drug resistant TB.

Selected Publications

Hosseinipour MC*, Bisson GP*, Miyahara S, Sun X, Moses A, Riviere C, Kirui FK, Badal-Faesen S, Lagat D, Nyirenda M, Naidoo K, Hakim J, Mugyenyi P, Henostroza G, Leger PD, Lama JR, Mohapi L, Alave J, Mave V, Veloso VG, Pillay S, Kumarasamy N, Bao J, Hogg E, Jones L, Zolopa A, Kumwenda J, Gupta A and the Adult AIDS Clinical Trials Group A5274 (REMEMBER) Study Team: Empiric Tuberculosis Therapy versus Isoniazid in Advanced HIV-infected Adult Outpatients Initiating Antiretroviral Therapy: a Multi-Country Randomized Controlled Trial. The Lancet 387 (10024): 1198-209, March 2016 Notes: *Contributed equally.

Gross R, Bellamy S, Ratshaa B, Han X, Steenhoff A, Mosepele M, Bisson GP: Effects of Alcohol Use and Sex on Antiretroviral Therapy Outcomes in Botswana: A Cohort Study. Addiction July 2016 Notes: Epub ahead of print.

Zentner I, Schlecht H, Khensouvann L Tamuhla N, Kutzler M, Ivaturi V, Pasipanodya J, Gumbo T, Peloquin C, Bisson GP, Vinnard C : Urine Colorimetry to Detect Low Rifampin Exposure during Tuberculosis Therapy: A Proof-of-Concept Study BMC Infectious Diseases 16(1): 242, June 2016.

Ravimohan S, Tamuhla N, Nfanyana K, Steenhoff AP, Letlhogile R, Frank I, MacGregor RR, Gross R, Weissman D, Bisson GP: Robust Reconstitution of Tuberculosis-Specific Polyfunctional CD4+ T-Cell Responses and Rising Systemic Interleukin 6 in Paradoxical Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome. Clinical Infectious Diseases 62(6): 795-803, March 2016.

Ravimohan S, Tamuhla N, Kung SJ, Nfanyana K, Steenhoff AP, Gross R, Weissman D, Bisson GP: Matrix metalloproteinases in TB-IRIS and impaired lung function among advanced HIV/TB co-infected patients initiating ART. eBiomedicine. Elsevier, 3: 100-107, January 2016.

Han JH, Gordon K, Womack JA, Gibert CL, Leaf DA, Rimland D, Rodriquez-Barradas MC, Bisson GP : Comparative Effectiveness of Diabetic Oral Medications among HIV-Infected and HIV-Uninfected Veterans. Diabetes Care In press 2016.

C Vinnard, Ravimohan S, Tamuhla N, Ivaturi V, Pasipanodya J, Kant S, Weissman D, Gumbo T, Bisson GP: Immune Activation and Isoniazid Metabolism in HIV-associated Tuberculosis. British Journal of Clinical Pharmacology In press, 2016.

Bearden D, Steenhoff A, Dlugos D, Kolson D, Mehta P, Kessler S, Lowenthal E, Monokwane B, Anabwani G, Bisson GP: Early Antiretroviral Therapy is Protective against Epilepsy in Children with Human Immunodeficiency Virus Infection in Botswana. JAIDS 69(2): 193-199, June 2015.

Molefi M, Chofle AA, Molloy SF, Kalluvya S, Changalucha JM, Cainelli F ,Leeme T, Lekwape N, Goldberg DW, Haverkamp M, Bisson GP, Perfect JR, Letang E, Fenner L, Meintjes G, Burton R, Makadzange T, Ndhlovu CE, Hope W, Harrison T, Jarvis JN: AMBITION-cm: intermittent high dose AmBisome on a high dose fluconazole backbone for cryptococcal meningitis induction therapy in sub-Saharan Africa: study protocol for a randomized controlled trial. Trials 16(1): 276, June 2015.

Ravimohan S, Tamuhla N, Steenhoff AP, Letlhogile R, Nfanyanam K, Bellamy S, MacGregor RR, Gross R, Weissman D, Bisson GP: Immunological profiling of tuberculosis-associated immune reconstitution inflammatory syndrome and non-immune reconstitution inflammatory syndrome death in HIV-infected adults with pulmonary tuberculosis starting antiretroviral therapy: a prospective observational cohort study. The Lancet Infectious Diseases 15(4): 429-438, April 2015.

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Last updated: 10/17/2016
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