Jason D. Christie, MD, MSCE
Hospital of the University of Pennsylvania
Center for Clinical Epidemiology and Biostatistics
University of Pennsylvania School of Medicine
423 Guardian Drive
717 Blockley Hall
Philadelphia, PA 19104
Fax: (215) 573-0198
Brown University, 1989.
Columbia University, 1993.
M.S.C.E. (Clinical Epidemiology)
University of Pennsylvania, 2002.
Resident in Medicine, Hospital of the University of Pennsylvania, 1993-1996.
Chief Medical Resident, Hospital of the University of Pennsylvania, 1996-1997.
Fellow, Division of Pulmonary and Critical Care Medicine, Hospital of the University of Pennsylvania , 1997-2000.
Fellow, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, 1998-2000.
Internal Medicine, 1996.
Pulmonary Medicine, 2000.
Critical Care Medicine, 2001.
Internal Medicine, 2006.
Pulmonary Disease, 2009.
Critical Care Medicine, 2010.
Description of Research ExpertiseDr. Christie's translational research studies involve the role of oxidative stress, coagulation/fibrinolysis and inflammatory pathways in acute lung injury following lung transplantation (termed primary graft dysfunction); somatic genetic variation; gene expression; and protein biomarkers in the etiology and pathogenesis of acute lung injury in the transplant, sepsis, and trauma populations.
Selected PublicationsYoung J C, Chehoud C, Bittinger K, Bailey A, Diamond J M, Cantu E, Haas A R, Abbas A, Frye L, Christie J D, Bushman F D, Collman R G: Viral metagenomics reveal blooms of anelloviruses in the respiratory tract of lung transplant recipients. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 15(1): 200-9, Jan 2015.
Sayah David M, Mallavia Beñat, Liu Fengchun, Ortiz-Muñoz Guadalupe, Caudrillier Axelle, DerHovanessian Ariss, Ross David J, Lynch Iii Joseph P, Saggar Rajan, Ardehali Abbas, Ware Lorraine B, Christie Jason D, Belperio John A, Looney Mark R: Neutrophil Extracellular Traps Are Pathogenic in Primary Graft Dysfunction After Lung Transplantation. American journal of respiratory and critical care medicine Page: Epub ahead of print, Dec 2014.
Singer JP, Peterson ER, Snyder ME, Katz PP, Golden JA, D'Ovidio F, Bacchetta M, Sonett JR, Kukreja J, Shah L, Robbins H, Van Horn K, Shah RJ, Diamond JM, Wickersham N, Sun L, Hays S, Arcasoy SM, Palmer SM, Ware LB, Christie JD, Lederer DJ: Body composition and mortality after adult lung transplantation in the United States. Am J Respir Crit Care Med 190(9): 1003-1011, Nov 2014.
Ferguson JF, Meyer NJ, Qu L, Xue C, Liu Y, DerOhannessian SL, Rushefski M, Paschos GK, Tang S, Schadt EE, Li M, Christie JD, Reilly MP: Integrative genomics identifies 7p11.2 as a novel locus for fever and clinical stress response in humans. Hum Mol Genet Page: Epub ahead of print, Nov 2014.
Bittinger K, Charlson ES, Loy E, Shirley DJ, Haas AR, Laughlin A, Yi Y, Wu GD, Lewis JD, Frank I, Cantu E, Diamond JM, Christie JD, Collman RG, Bushman FD: Improved characterization of medically relevant fungi in the human respiratory tract using next-generation sequencing. Genome Biol 15(10): Epub ahead of print, Oct 2014.
Ortego A, Gaieski DF, Fuchs BD, Jones T, Halpern SD, Small DS, Sante SC, Drumheller B, Christie JD, Mikkelsen ME: Hospital-Based Acute Care Use in Survivors of Septic Shock. Crit Care Med Page: Epub ahead of print, Oct 2014.
Lund LH, Edwards LB, Kucheryavaya AY, Benden C, Christie JD, Dipchand AI, Dobbels F, Goldfarb SB, Levvey BJ, Meiser B, Yusen RD, Stehlik J; International Society of Heart and Lung Transplantation: The Registry of the International Society for Heart and Lung Transplantation: Thirty-first Official Adult Heart Transplant Report-2014; Focus Theme: Retransplantation. J Heart Lung Transplant 33(10): 996-1008, Oct 2014.
Benden C, Goldfarb SB, Edwards LB, Kucheryavaya AY, Christie JD, Dipchand AI, Dobbels F, Levvey BJ, Lund LH, Meiser B, Yusen RD, Stehlik J; International Society for Heart and Lung Transplantation: The registry of the international society for heart and lung transplantation: seventeenth official pediatric lung and heart-lung transplantation report-2014; focus theme: retransplantation. J Heart Lung Transplant 33(10): 1025-33, Oct 2014.
Walley KR, Thain KR, Russell JA, Reilly MP, Meyer NJ, Ferguson JF, Christie JD, Nakada TA, Fjell CD, Thair SA, Cirstea MS, Boyd JH: PCSK9 is a critical regulator of the innate immune response and septic shock outcome. Sci Transl Med 6(258): 258ra143, Oct 2014.
Meyer NJ, Ferguson JF, Feng R, Wang F, Patel PN, Li M, Xue C, Qu L, Liu Y, Boyd JH, Russell JA, Christie JD, Walley KR, Reilly MP: A functional synonymous coding variant in the IL1RN gene associates with survival in septic shock. Am J Respir Crit Care Med 190(6): 656-64, Sept 2014.
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