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Jason D. Christie, MD, MSCE

Robert M. Kotloff/Nancy Blumenthal Professor for Advanced Lung Disease
Member, Biomedical Graduate Group, Perelman School of Medicine at the University of Pennsylvania, Department of Biostatistics and Epidemiology
Senior Scholar, Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine at the University of Pennsylvania
Adjunct Investigator, Institute for Environmental Medicine, Perelman School of Medicine at the University of Pennsylvania
Director, Center for Translational Lung Biology, Perelman School of Medicine at the University of Pennsylvania
Program Leader for Transplantation, Institute for Immunology, Perelman School of Medicine at the University of Pennsylvania
Chief, Pulmonary, Allergy, and Critical Care Division, Perelman School of Medicine at the University of Pennsylvania
Department: Medicine

Contact information
Division of Pulmonary and Critical Care Medicine
Hospital of the University of Pennsylvania
Center for Clinical Epidemiology and Biostatistics
University of Pennsylvania School of Medicine
423 Guardian Drive
221 Blockley Hall
Philadelphia, PA 19104
Office: (215) 573-3209
Fax: (215) 573-0198
Graduate Group Affiliations
Sc.B. (Chemistry)
Brown University, 1989.
M.D. (Medicine)
Columbia University, 1993.
M.S.C.E. (Clinical Epidemiology)
University of Pennsylvania, 2002.
Post-Graduate Training
Resident in Medicine, Hospital of the University of Pennsylvania, 1993-1996.
Chief Medical Resident, Hospital of the University of Pennsylvania, 1996-1997.
Fellow, Division of Pulmonary and Critical Care Medicine, Hospital of the University of Pennsylvania , 1997-2000.
Fellow, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, 1998-2000.
Internal Medicine, 1996.
Pulmonary Medicine, 2000.
Critical Care Medicine, 2001.
Epidemiology, 2003.
Internal Medicine, 2006.
Pulmonary Disease, 2009.
Critical Care Medicine, 2010.
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Description of Research Expertise

Dr. Christie's career is focused on translational research studies of the risks, pathogenesis, treatment, and outcomes of acute lung injury in the transplant and non-transplant human populations. His research integrates new knowledge generated from bench studies with epidemiology approaches in well-phenotyped, large human populations to generate new definitions of human syndromes, improved diagnostics and prognostics, and targeted therapy approaches in advanced lung diseases and critical illness.

Dr. Christie is the founder of the lung transplant outcomes group (LTOG), which is a multicentered cohort study the etiology and pathogenesis of acute lung injury following lung transplantation (termed primary graft dysfunction). Active LTOG research themes focus on the mechanisms of clinical factors that elevate PGD risk, including donor smoke exposure, recipient obesity and body composition, pulmonary hypertension, alterations in lung microbiome, and autoimmunity to lung collagens. His multidisciplinary lung transplant research focuses on genetics, innate immunity, regulatory T-cells, innate lymphoid cell (ILC) populations in the lung, ischemia reperfusion injury, inflammation, and autoimmunity.

Selected Publications

Porteous Mary K, Lee James C, Lederer David J, Palmer Scott M, Cantu Edward, Shah Rupal J, Bellamy Scarlett L, Lama Vibha N, Bhorade Sangeeta M, Crespo Maria M, McDyer John F, Wille Keith M, Localio A Russell, Orens Jonathan B, Shah Pali D, Weinacker Ann B, Arcasoy Selim, Wilkes David S, Ware Lorraine B, Christie Jason D, Kawut Steven M, Diamond Joshua M: Clinical Risk Factors and Prognostic Model for Primary Graft Dysfunction after Lung Transplantation in Patients with Pulmonary Hypertension. Annals of the American Thoracic Society Jul 2017.

Borders CF, Suzuki Y, Lasky J, Schaufler C, Mallem D, Lee J, Carney K, Bellamy SL, Bermudez CA, Localio AR, Christie JD, Diamond JM, Cantu E: Massive Donor Transfusion Potentially Increases Recipient Mortality After Lung Transplantation. Journal of Thoracic Cardiovascular Surgery 153(5): 1197-1203, May 2017.

Lama Vibha N, Belperio John A, Christie Jason D, El-Chemaly Souheil, Fishbein Michael C, Gelman Andrew E, Hancock Wayne W, Keshavjee Shaf, Kreisel Daniel, Laubach Victor E, Looney Mark R, McDyer John F, Mohanakumar Thalachallour, Shilling Rebecca A, Panoskaltsis-Mortari Angela, Wilkes David S, Eu Jerry P, Nicolls Mark R: Models of Lung Transplant Research: a consensus statement from the National Heart, Lung, and Blood Institute workshop. JCI insight 2(9), May 2017.

Holena Daniel N, Kaufman Elinore J, Delgado M Kit, Wiebe Douglas J, Carr Brendan G, Christie Jason D, Reilly Patrick M: A Metric of Our Own: Failure to Rescue After Trauma. The journal of trauma and acute care surgery May 2017.

Patterson KC, Shah RJ, Porteous MK, Christie JD, D'Errico C, Chadwick M, Triano M, Deshpande C, Rossman MD, Litzky LA, Kreider ME, Miller WT Jr: Interstitial Lung Disease in the Elderly. Chest 151(4): 838-844, April 2017.

Baldwin Matthew R, Singer Jonathan P, Huang Debbie, Sell Jessica, Gonzalez Wendy C, Pollack Lauren, Maurer Mathew S, D'Ovidio Frank F, Bacchetta Matthew, Sonett Joshua R, Arcasoy Selim M, Shah Lori, Robbins Hilary, Hays Steven R, Kukreja Jasleen, Greenland John R, Shah Rupal J, Leard Lorriana, Morrell Matthew, Gries Cynthia, Katz Patricia P, Christie Jason D, Diamond Joshua M, Lederer David J: Refining Low Physical Activity Measurement Improves Frailty Assessment in Advanced Lung Disease and Survivors of Critical Illness. Annals of the American Thoracic Society Apr 2017.

Tong Y, Udupa JK, Torigian DA, Odhner D, Wu C, Pednekar G, Palmer S, Rozenshtein A, Shirk MA, Newell JD, Porteous M, Diamond JM, Christie JD, Lederer DJ: Chest Fat Quantification via CT Based on Standardized Anatomy Space in Adult Lung Transplant Candidates. PLoS One 12(1): e0168932, January 2017.

Diamond JM, Arcasoy S, McDonnough JA, Sonett JR, Bacchetta M, D'Ovidio F, Cantu E, Bermudez CA, McBurnie A, Rushefski M, Kalman LH, Oyster M, D'Errico C, Suzuki Y, Giles JT, Ferrante A, Lippel M, Singh G, Lederer DJ, Christie JD: Adipose Gene Expression Profile Changes with Lung Allograft Reperfusion. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 17(1): 239-245, Jan 2017.

Diamond JM, Cantu E, Porteous M, Suzuki Y, Meyer KC, Lederer D, Milewski RK, Arcasoy S, D'Ovidio F, Bacchetta M, Sonett JR, Singh G, Costa J, Tobias JW, Rodriguez H, Van Deerlin VM, Olthoff KM, Shaked A, Chang BL, Christie JD: Peripheral Blood Gene Expression Changes Associated with Primary Graft Dysfunction after Lung Transplantation. American Journal of Transplant Epub ahead of Print, January 2017.

Anderson BJ, Reilly JP, Shashaty MG, Palakshappa JA, Wysoczanski A, Dunn TG, Kazi A, Tommasini A, Mikkelsen ME, Schweickert WD, Kolson DL, Christie JD, Meyer NJ: Admission Plasma Levels of the Neuronal Injury Marker Neuron-specific Enolase are Associated with Mortality and Delirium in Sepsis. Journal of Critical Care 36: 18-23, December 2016.

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Last updated: 09/05/2017
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