Jason D. Christie

faculty photo
Associate Professor of Medicine
Member, Biomedical Graduate Group, Perelman School of Medicine at the University of Pennsylvania, Department of Biostatistics and Epidemiology
Senior Scholar, Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine at the University of Pennsylvania
Director, Special Programs in Education, Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine at the University of Pennsylvania
Co-Director, Research Fellowship Training, Pulmonary and Critical Care Fellowship Program, Perelman School of Medicine at the University of Pennsylvania
Director of Clinical Research, Pulmonary and Critical Care Division, Perelman School of Medicine at the University of Pennsylvania
Chief, Section of Medical Critical Care, Perelman School of Medicine at the University of Pennsylvania
Adjunct Investigator, Institute for Environmental Medicine, Perelman School of Medicine at the University of Pennsylvania
Director, Center for Translational Lung Biology, Perelman School of Medicine at the University of Pennsylvania
Program Leader for Transplantation, Institute for Immunology, Perelman School of Medicine at the University of Pennsylvania
Department: Medicine

Contact information
Division of Pulmonary and Critical Care Medicine
Hospital of the University of Pennsylvania
Center for Clinical Epidemiology and Biostatistics
University of Pennsylvania School of Medicine
423 Guardian Drive
717 Blockley Hall
Philadelphia, PA 19104
Office: (215) 573-3209
Fax: (215) 573-0198
Graduate Group Affiliations
Education:
Sc.B. (Chemistry)
Brown University, 1989.
M.D. (Medicine)
Columbia University, 1993.
M.S.C.E. (Clinical Epidemiology)
University of Pennsylvania, 2002.
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Description of Research Expertise

Dr. Christie's translational research studies involve the role of oxidative stress, coagulation/fibrinolysis and inflammatory pathways in acute lung injury following lung transplantation (termed primary graft dysfunction); somatic genetic variation; gene expression; and protein biomarkers in the etiology and pathogenesis of acute lung injury in the transplant, sepsis, and trauma populations.

Description of Itmat Expertise

Dr. Christie's translational research studies involve the role of oxidative stress, coagulation/fibrinolysis and inflammatory pathways in acute lung injury following lung transplantation (termed primary graft dysfunction); somatic genetic variation; gene expression; and protein biomarkers in the etiology and pathogenesis of acute lung injury in the transplant, sepsis, and trauma populations.

Selected Publications

Singer JP, Peterson ER, Snyder ME, Katz PP, Golden JA, D'Ovidio F, Bacchetta M, Sonett JR, Kukreja J, Shah L, Robbins H, Van Horn K, Shah RJ, Diamond JM, Wickersham N, Sun L, Hays S, Arcasoy SM, Palmer SM, Ware LB, Christie JD, Lederer DJ: Body composition and mortality after adult lung transplantation in the United States. Am J Respir Crit Care Med 190(9): 1003-1011, Nov 2014.

Bittinger K, Charlson ES, Loy E, Shirley DJ, Haas AR, Laughlin A, Yi Y, Wu GD, Lewis JD, Frank I, Cantu E, Diamond JM, Christie JD, Collman RG, Bushman FD: Improved characterization of medically relevant fungi in the human respiratory tract using next-generation sequencing. Genome Biol 15(10): Epub ahead of print, Oct 2014.

Lund LH, Edwards LB, Kucheryavaya AY, Benden C, Christie JD, Dipchand AI, Dobbels F, Goldfarb SB, Levvey BJ, Meiser B, Yusen RD, Stehlik J; International Society of Heart and Lung Transplantation: The Registry of the International Society for Heart and Lung Transplantation: Thirty-first Official Adult Heart Transplant Report-2014; Focus Theme: Retransplantation. J Heart Lung Transplant 33(10): 996-1008, Oct 2014.

Benden C, Goldfarb SB, Edwards LB, Kucheryavaya AY, Christie JD, Dipchand AI, Dobbels F, Levvey BJ, Lund LH, Meiser B, Yusen RD, Stehlik J; International Society for Heart and Lung Transplantation: The registry of the international society for heart and lung transplantation: seventeenth official pediatric lung and heart-lung transplantation report-2014; focus theme: retransplantation. J Heart Lung Transplant 33(10): 1025-33, Oct 2014.

Walley KR, Thain KR, Russell JA, Reilly MP, Meyer NJ, Ferguson JF, Christie JD, Nakada TA, Fjell CD, Thair SA, Cirstea MS, Boyd JH: PCSK9 is a critical regulator of the innate immune response and septic shock outcome. Sci Transl Med 6(258): 258ra143, Oct 2014.

Meyer NJ, Ferguson JF, Feng R, Wang F, Patel PN, Li M, Xue C, Qu L, Liu Y, Boyd JH, Russell JA, Christie JD, Walley KR, Reilly MP: A functional synonymous coding variant in the IL1RN gene associates with survival in septic shock. Am J Respir Crit Care Med 190(6): 656-64, Sept 2014.

Shashaty MGS, Kalkan E, Bellamy SL, Reilly JP, Holena DN, Cummins K, Lanken PN, Feldman HI, Reilly MP, Udupa JK, Christie JD: Computed tomography-defined abdominal adiposity is associated with acute kidney injury in critically ill trauma patients. Crit Care Med 42(7): 1619-28, July 2014.

Reilly JP, Bellamy S, Shashaty MG, Gallop R, Meyer NJ, Lanken PN, Kaplan S, Holena DN, May AK, Ware LB, Christie JD: Heterogeneous phenotypes of acute respiratory distress syndrome after major trauma. Ann Am Thorac Soc 11(5): 728-36, Jun 2014.

Shah RJ, Emtiazjoo AM, Diamond JM, Smith PA, Roe DW, Wille KM, Orens JB, Ware LB, Weinacker A, Lama VN, Bhorade SM, Palmer SM, Crespo M, Lederer DJ, Cantu E, Eckert GJ, Christie JD, Wilkes DS: Plasma complement levels are associated with primary graft dysfunction and mortality after lung transplantation. Am J Respir Crit Care Med 189(12): 1564-7, Jun 2014.

Cohen DG, Christie JD, Anderson BJ, Diamond JM, Judy RP, Shah RJ, Cantu E, Bellamy SL, Blumenthal NP, Demissie E, Hopkins RO, Mikkelsen ME: Cognitive function, mental health, and health-related quality of life after lung transplantation. Ann Am Thorac Soc 11(4): 522-30, May 2014.

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Last updated: 11/03/2014
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