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Ron C Anafi, M.D., Ph.D.

Assistant Professor of Medicine at the Hospital of the University of Pennsylvania
Faculty Scholar, Penn Institute for Bioinformatics
Department: Medicine

Contact information
Translational Research Laboratories, Suite 2100
125 South 31st Street
Philadelphia, PA 19104
B.S.E. (Biomedical engineering and philosophy)
Tulane University, 1995.
Ph.D. (Applied mechanics)
University of Minnesota, 2002.
University of Minnesota, 2004.
Post-Graduate Training
Intern in Medicine, University of Vermont/Fletcher Allen Hospital, 2004-2005.
Resident in Medicine, University of Vermont/Fletcher Allen Hospital, 2005-2007.
Research Fellow (part-time), Vermont Lung Center , 2007-2008.
Fellowship in Sleep Medicine, Hospital of the University of Pennsylvania, 2008-2009.
Research fellow, Center for Sleep and Circadian Neurobiology, University of Pennsylvania, 2009-2011.
American Board of Internal Medicine - Internal Medicine, 2007.
American Board of Internal Medicine – Sleep Medicine, 2009.
Permanent link
> Perelman School of Medicine   > Faculty   > Details

Selected Publications

Anafi RC, Francey LJ, Hogenesch JB, Kim J: CYCLOPS reveals human transcriptional rhythms in health and disease. Proceedings of the National Academy of Sciences of the United States of America 114(20): 5312-5317, May 2017.

Krishnaiah SY, Wu G, Altman B, Growe J, Rhoades SD, Coldren F, Venkataraman A, Olarerin-George AO, Francey LJ, Mukherjee S, Girish S, Selby CP, Cal S, Er U, Sianati B, Sengupta A, Anafi RC, Kavakli IH, Sancar A, Baur JA, Dang CV, Hogenesch JB, Weljie AM: Clock regulation of metabolites reveals coupling between transcription and metabolism. Cell Metabolism 25(4): 961-974.e4, Apr 2017.

Wu G, Anafi RC, Hughes ME, Kornacker K, Hogenesch JB: MetaCycle: an integrated R package to evaluate periodicity in large scale data. Bioinformatics 32(21): 3351-3353, Nov 2016.

Zhang R, Podtelezhnikov AA, Hogenesch JB, Anafi RC: Discovering biology in periodic data through Phase Set Enrichment Analysis (PSEA). Journal of Biological Rhythms 31(3): 244-257, Jun 2016.

Arnardottir ES, Nikonova EV, Shockley KR, Podtelezhnikov AA, Anafi RC, Tanis KQ, Maislin G, Stone DJ, Renger JJ, Winrow CJ, Pack AI: Blood-gene expression reveals reduced circadian rhythmicity in individuals resistant to sleep deprivation. Sleep 37(10): 1589-1600, Oct 2014.

Anafi RC, Lee Y, Sato TK, Venkataraman A, Ramanathan C, Kavakli IH, Hughes ME, Baggs JE, Growe J, Liu AC, Kim J, Hogenesch J: Machine learning helps identify CHRONO as a circadian clock component. PLoS Biology 12(4): e1001840, Apr 2014.

Deckard A, Anafi RC, Hogenesch JB, Haase SB, Harer J: Design and analysis of large-scale biological rhythm studies: a comparison of algorithms for detecting periodic signals in biological data. Bioinformatics (Oxford, England) 29(24): 3174-3180, Dec 2013.

Anafi RC, Pellegrino R, Shockley KR, Romer M, Tufik S, Pack A: Sleep is not just for the brain: transcriptional responses to sleep in peripheral tissues. BMC Genomics 14: 362, May 2013.

Schwartz BL, Anafi RC, Aliyeva M, Thompson-Figueroa JA, Allen GB, Lundblad LKA, Bates JHT: Effects of central airway shunting on the mechanical impedance of the mouse lung. Annals of Biomedical Engineering 39(1): 497-507, Jan 2011.

Anafi RC, Bates JHT: Balancing robustness against the dangers of multiple attractors in a Hopfield-type model of biological attractors. PLoS One 5(12): e14413, Dec 2010.

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Last updated: 04/03/2018
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