Steven E. Arnold

faculty photo
Professor of Psychiatry
Associate Director, Institute on Aging, University of Pennsylvania, Philadelphia, PA
Associate Director, Alzheimer Disease Core Center, University of Pennsylvania
Director, Geriatric Psychiatry Section, University of Pennsylvania
Director, Penn Memory Center/Alzheimer's Disease Center Clincal Core, University of Pennsylvania, Philadelphia, PA
Department: Psychiatry

Contact information
Penn Memory Center
3615 Chestnut Street
or
2205 Translational Research Laboratories
123 South 31st Street
Philadelphia, PA 19104
Office: (215) 349-8225
Fax: (215) 349-8540
Lab: (215) 573-2840
Graduate Group Affiliations
Education:
M.D. (Medicine)
Boston University, 1983.
B.A. (Medical Science, Philosophy)
Boston University, Summa cum laude , 1983.
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Description of Research Expertise

schizophrenia; neuropsychiatry; cognition in aging and neurodegenerative dementias; clinicopathological correlation studies; postmortem research; cellular and molecular neuropathology; quantitative microscopy.

Description of Itmat Expertise

Dr. Arnold conducts studies on cellular and molecular mechanisms of complex neuropsychiatric disorders, especially schizophrenia, as well as neuropathological substrates of cognitive impairment in aging and dementias.

Selected Publications

DeJesus-Cortes, H.J., Nogueras-Ortiz, C.J., Gearing, M., Arnold, S.E., Vega, I.E.: Amphiphysin-1 protein level changes associated with tau-mediated neurodegeneration. Neuroreport 23(16): 942-946, Nov 2012.

Naylor, M.D., Karlawish, J.H., Arnold, S.E., Khachaturian, A.S., Khachaturian, Z.S., Lee, V.M., Baumgart, M., Banerjee, S., Beck, C., Blennow, K., Brookmeyer, R., Brunden, K.R., Buckwalter, K.C., Comer,M., Covinsky, K., Feinberg, L.F., Frisoni, G., Green, C., Guimaraes, R.M., Gwyther, L.P., Hefti, F.F., Hutton, M., Kawas, C., Kent, D.M., Kuller, L., Langa, K.M., Mahley, R.W., Maslow, K., Masters, C.L., Meier, D.E., Neumann, P.J., Paul, S.M., Peterson, R.C., Sager, M.A., Sano, M., Schenk, D., Soares, H., Sperling, R.A., Stahl, S.M., vanDeerlin, V., Stern, Y., Weir, D., Wolk, D.A., Trojanowski, J.Q.: Advancing Alzheimer's disease diagnosis, treatment, and care: Recommendations from the Ware Invitational Summit. Alzheimers Dement 8(5): 445-52, Sep 2012.

Wolk, D.A., Zhang, Z., Boudhar, S., Clark, C.M., Pontecorvo, M.J., Arnold, S.E.: Amyloid imaging in Alzheimer's disease: comparison of florbetapir and Pittsburgh compound-B positron emission tomography. J Neurol Neurosurg Psychiatry 83(9): 923-6, Sep 2012.

Zhang, Q., Stafford, R.B., Wang, Z., Arnold, S.E., Wolk, D.A., Detre, J.A.: Microvascular Perfusion Based on Arterial Spin Labeled Perfusion MRI as a Measure of Vascular Risk in Alzheimer's Disease. J Alzheimers Dis. Aug 2012.

Hu, W.T., Holtzman, D.M., Fagan, A.M., Shaw, L.M., Perrin, R., Arnold, S.E., Grossman, M., Xiong, C., Craig-Schapiro, R., Clark, C.M., Pickering, E., Kuhn, M., Chen, Y., VanDeerlin, V.M., McClusky, L., Elman, L., Karlawish, J., Chen-Plotkin, A., Hurtig, H.I., Siderowf, A., Swenson, F., Lee, V.M., Morris, J.C., Trojanowski, J.Q., Soares, H.: Plasma multianalyte profiling in mild cognitive impairment and Alzheimer's disease. Neurology 79(9): 897-905, Aug 2012.

Irwin, D. J., McMillan, C.T., Toledo, J.B., Arnold, S.E., Shaw, L.M., Wang, L.S., VanDeerlin, V., Lee, V.M., Trojanowski, J.Q., Grossman, M.: Comparison of cerebrospinal fluid levels of tau and ab 1-42 in Alzheimer disease and frontotemporal degeneration using 2 analytical platforms. Arch Neurol 69(8): 1018-25, Aug 2012.

Toledo, J.B., Brettschneider, J., Grossman, M., Arnold, S.E., Hu, W.T., Xie, S.X., Lee, V.M., Shaw, L.M., Trojanowski, J.Q.: CSF biomarkers cutoffs: the importance of coincident neuropathological diseases. Acta Neuropathol. 124(1): 23-35, Jul 2012.

Farlow, M., Arnold, S.E., vanDyck, C.H., Aisen, P.S., Snider, B.J., Porsteinsson, A.P., Friedrich, S., Dean, R.A., Gonzales, C., Sethuraman, G., DeMattos, R.B., Mohs, R., Paul, S.M., Siemers, E.R.: Safety and biomarker effects of solanezumab in patients with Alzheimer's disease. Alzheimers Dement 8(4): 261-71, Jul 2012.

Newberg, A.B., Arnold, S.E., Wintering, N., Rovner, B.W., Alavi, A.: Initial clinical comparison of 18F-florbetapir and 18F-FDG PET in patients with Alzheimer disease and controls. J Nucl Med 53(6): 902-7, Jun 2012.

Talbot, K., Wang, H.Y., Kazi, H., Han, L.Y., Bakshi, K.P., Stucky, A., Fuino, R.L., Kawaguchi, K.R., Samoyedny, A.J., Wilson, R.S., Arvanitakis, Z., Schneider, J.A., Wolf, B.A., Bennett, D.A., Trojanowski, J.Q., Arnold, S.E.: Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline. J Clin Invest 122(4): 1316-38, Apr 2012.

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Last updated: 01/24/2013
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