Keith A. Cengel
Assistant Professor of Radiation Oncology at the Hospital of the University of Pennsylvania
Director, Photodynamic Therapy Program, University of Pennsylvania
Department: Radiation Oncology
Contact information
3620 Hamilton Walk
Department of Radiation Oncology
180 G John Morgan Building
Philadelphia, PA 19104
Department of Radiation Oncology
180 G John Morgan Building
Philadelphia, PA 19104
Office: 215-898-1035
Fax: 215-349-5445
Fax: 215-349-5445
Email:
keith.cengel@uphs.upenn.edu
keith.cengel@uphs.upenn.edu
Publications
Education:
BS (Biochemistry)
University of Illinois at Urbana-Champaign, 1991.
MS (Cellular/Molecular Biology)
University of Illinois at Urbana-Champaign, 1993.
PhD (Cellular/Molecular Biology)
University of Illinois at Urbana-Champaign, 1998.
MD
University of Illinois at Urbana-Champaign, 2001.
Permanent linkBS (Biochemistry)
University of Illinois at Urbana-Champaign, 1991.
MS (Cellular/Molecular Biology)
University of Illinois at Urbana-Champaign, 1993.
PhD (Cellular/Molecular Biology)
University of Illinois at Urbana-Champaign, 1998.
MD
University of Illinois at Urbana-Champaign, 2001.
Description of Research Expertise
1. Defining Mechanisms and Reducing Toxicity from Normal Tissue Damage Caused by Ionizing Radiation: These projects center on modeling the physical patterns of dose deposition by x-rays, gamma rays and charged particles and determining the mechanism(s) that lead to normal tissue toxicity. From a greater understanding of these mechanisms, these projects seek to identify and formulate potential radiation protectors and mitigators for use in human medicine.2. Cellular Signaling and PDT cytotoxicity: This project is focused on defining the molecular mechanism by which PDT-initiated growth factor and anti-oxidant signaling leads to decreased PDT-mediated cytotoxicity in human cancer cells and tumors.
3. Clinical trials of RT and PDT: These projects involve using insights gained from pre-clinical studies to design early phase interventional trials for patients with cancers that are difficult to treat using current standard modalities.
Selected Publications
Sanzari, JK, Wan, XS, Wroe, AJ, Rightnar, S, Cengel, KA, Diffenderfer, ES, Krigsfeld, GS, Gridley, DS, Kennedy, AR: Acute Hematological Effects of Solar Particle Event Proton Radiation in the Porcine Model. Radiat Res in Press, 2013.Cengel, KA, Sanzari, J, Billings, P, Diffenderfer, ES, Kennedy, AR: Determining The Whole Body Radiation Repose To Solar Particle Events With Differing Energy-fluence Profiles NASA Human Research Program Investigator's Workshop, Galveston, TX 2013.
Cengel, KA, Kennedy AR: NSBRI Center For Acute Radiation Research: Dosimetric and Practical Considerations for Simulating Solar Particle Event Exposure for Earth Based Model Systems. National Space Biomedical Research Institute Radiation Effects Team 2013.
Chandra Abhishek, Lan Shenghui, Zhu Ji, Lin Tiao, Zhang Xianrong, Siclari Valerie A, Altman Allison R, Cengel Keith A, Liu X Sherry, Qin Ling: PTH prevents the adverse effects of focal radiation on bone architecture in young rats. Bone 2013.
Pietrofesa Ralph, Turowski Jason, Tyagi Sonia, Dukes Floyd, Arguiri Evguenia, Busch Theresa M, Gallagher-Colombo Shannon M, Solomides Charalambos C, Cengel Keith A, Christofidou-Solomidou Melpo: Radiation mitigating properties of the lignan component in flaxseed. BMC cancer 13: 179, 2013.
Cengel, KA, Sanzari, J, Billings, P, Diffenderfer, ES, Kennedy, AR: Evaluating Radiation Repose And Countermeasures For Exposure To Solar Particle Events With Differing Energy-Fluence Profiles. Heavy Ion in Therapy and Space Radiation Symposium 2013, Chiba, Japan 2013.
Whaley JT, Kirk M, Cengel K, McDonough J, Bekelman J, Christodouleas JP.: Protective Effect of Transparent Film Dressing on Proton Therapy Induced Skin Reactions. Radiat Oncol 8: 19, 2013.
Edmonds, C, Hagan, S, Gallagher-Colombo, S, Busch, T, Cengel, KA: Photodynamic Therapy Activated Signaling From Epidermal Growth Factor Receptor and STAT3: Targeting Survival Pathways to Increase PDT Efficacy in Ovarian And Lung Cancer. Cancer Biol Ther 13: 1463-1470, 2012.
Cengel, K, Yendamuri, S, Demmy, T, Culligan, M, Schofield, M, Smith, D, Punekar, S, Sterman, D, Stevenson, J, Busch, T Glatstein, E, Hahn, S, Friedberg, J : Qualitative And Quantitative Differences in the Toxicity Of HPPH-Mediated PDT with a 24 Versus 48-Hour Drug Light Interval: Moving from the Bedside to the Bench and Back. SPIE Photonics West, San Francisco, CA 2012.
Fishbein, L, Bonner, L, Torigian, DA, Nathanson, KL, Cohen, DL, Pryma, D, Cengel, KA : External Beam Radiation Therapy (EBRT) for Patients with Malignant Pheochromocytoma and Non-Head and Neck Paraganglioma: Combination with 131I-MIBG. Horm Metab Res 44: 405-410, 2012.