Mark A Oyama

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Professor of Cardiology
Professor, Department of Clinical Studies - Philadelphia, University of Pennsylvania School of Veterinary Medicine
Professor, Department of Clinical Studies - Philadelphia, University of Pennsylvania School of Veterinary Medicine
Department: Cardiology

Contact information
Department of Clinical Studies-Philadelphia
Matthew J. Ryan Veterinary Hospital of the University of Pennsylvania
School of Veterinary Medicine
University of Pennsylvania
3900 Delancey St.
Philadelphia, PA 19104
Office: 215-898-2964
Fax: 215-573-6232
Education:
DVM (Doctor Veterinary Medicine)
University of Illinois, 1994.
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Description of Research Expertise

Cardiac biomarkers (troponin, natriuretic peptides [BNP, ANP])
Acquired mitral valve disease (myxomatous degeneration)
Cardiomyopathy (canine dilated cardiomyopathy)
Clinical trials
Serotonin signaling and valve disease
Calstabin2 (FKBP12.6) and ryanodine receptors in cardiomyopathy
Animal models of heart disease and heart failure
Quality of life issues in dogs and cats with heart disease

Description of Itmat Expertise

Dr. Oyama is involved in animal models of human disease and translational research, in particular, he is involved in research concerning dilated cardiomyopathy and mitral valve disease, and cardiac biomarkers.

Selected Publications

Freeman, L. M., Rush, J. E., Oyama, M. A., MacDonald, K. A., Cunningham, S. M., Bulmer, B., MacGregor, J. M., Laste, N. J., Malakoff, R. L., Hall, D. J., Trafny, D. J.: Development and evaluation of a questionnaire for assessment of health-related quality of life in cats with cardiac disease. Javma-Journal of the American Veterinary Medical Association 240(10): 1188-1193, 2012.

Summerfield, N. J., Boswood, A., O'Grady, M. R., Gordon, S. G., Dukes-McEwan, J., Oyama, M. A., Smith, S., Patteson, M., French, A. T., Culshaw, G. J., Braz-Ruivo, L., Estrada, A., O'Sullivan, M. L., Loureiro, J., Willis, R., Watson, P.: Efficacy of Pimobendan in the Prevention of Congestive Heart Failure or Sudden Death in Doberman Pinschers with Preclinical Dilated Cardiomyopathy (The PROTECT Study). Journal of Veterinary Internal Medicine 26(6): 1337-1349, 2012.

Singletary, G. E., Rush, J. E., Fox, P. R., Stepien, R. L., Oyama, M. A.: Effect of NT-pro-BNP Assay on Accuracy and Confidence of General Practitioners in Diagnosing Heart Failure or Respiratory Disease in Cats with Respiratory Signs. Journal of Veterinary Internal Medicine 26(3): 542-546, 2012.

Singletary, G. E., Morris, N. A., O'Sullivan, M. L., Gordon, S. G., Oyama, M. A.: Prospective Evaluation of NT-proBNP Assay to Detect Occult Dilated Cardiomyopathy and Predict Survival in Doberman Pinschers. Journal of Veterinary Internal Medicine 26(6): 1330-1336, 2012.

Reynolds, C. A., Brown, D. C., Rush, J. E., Fox, P. R., Nguyenba, T. P., Lehmkuhl, L. B., Gordon, S. G., Kellihan, H. B., Stepien, R. L., Lefbom, B. K., Kate Meier, C., Oyama, M. A.: Prediction of first onset of congestive heart failure in dogs with degenerative mitral valve disease: The PREDICT cohort study. Journal of Veterinary Cardiology 14(1): 193-202, 2012.

Peddle, G. D., Singletary, G. E., Reynolds, C. A., Trafny, D. J., MacHen, M. C., Oyama, M. A.: Effect of torsemide and furosemide on clinical, laboratory, radiographic and quality of life variables in dogs with heart failure secondary to mitral valve disease. Journal of Veterinary Cardiology 14(1): 253-259, 2012.

Meurs, K. M., Lahmers, S., Keene, B. W., White, S. N., Oyama, M. A., Mauceli, E., Lindblad-Toh, K.: A splice site mutation in a gene encoding for PDK4, a mitochondrial protein, is associated with the development of dilated cardiomyopathy in the Doberman pinscher. Human Genetics 131(8): 1319-1325, 2012.

Meurs, K. M., Heaney, A. M., Atkins, C. E., DeFrancesco, T. C., Fox, P. R., Keene, B. W., Kellihan, H. B., Miller, M. W., Oyama, M. A., Oaks, J. L.: Comparison of Polymerase Chain Reaction with Bacterial 16s Primers to Blood Culture to Identify Bacteremia in Dogs with Suspected Bacterial Endocarditis. Journal of Veterinary Internal Medicine 25(4): 959-962, 2011.

Oyama, M. A., Peddle, G. D., Reynolds, C. A., Singletary, G. E.: Use of the loop diuretic torsemide in three dogs with advanced heart failure. Journal of Veterinary Cardiology 13(4): 287-292, 2011.

Oyama, M. A., Levy, R. J.: Insights into Serotonin Signaling Mechanisms Associated with Canine Degenerative Mitral Valve Disease. Journal of Veterinary Internal Medicine 24(1): 27-36, 2010.

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Last updated: 04/10/2014
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