Mark A Oyama

faculty photo
Professor of Cardiology
Chief, Section of Cardiology, Veterinary Hospital of the University of Pennsylvania, School of Veterinary Medicine
Professor, Department of Clinical Studies - Philadelphia, University of Pennsylvania School of Veterinary Medicine
Department: Cardiology

Contact information
Department of Clinical Studies-Philadelphia
Ryan Veterinary Hospital of the University of Pennsylvania
School of Veterinary Medicine
University of Pennsylvania
3900 Spruce St.
Philadelphia, PA 19104
Office: 215-898-3331
DVM (Doctor Veterinary Medicine)
University of Illinois, 1994.
MSCE (Masters of Science in Clinical Epidemiology)
University of Pennslyvania, 2015.
Permanent link

Description of Research Expertise

Cardiac biomarkers (troponin, natriuretic peptides [BNP, ANP])
Diuretic resistance
Clinical trials
Serotonin signaling and myxomatous valve disease
Animal models of heart disease and heart failure
Epidemiology and biostatistics

Description of Itmat Expertise

Dr. Oyama is involved in animal models of human disease and translational research, in particular, he is involved in research involving serotonin signaling in myxomatous mitral valve disease.

Selected Publications

Hezzell M J, Rush J E, Humm K, Rozanski E A, Sargent J, Connolly D J, Boswood A, Oyama M A: Differentiation of Cardiac from Noncardiac Pleural Effusions in Cats using Second-Generation Quantitative and Point-of-Care NT-proBNP Measurements. Journal of veterinary internal medicine / American College of Veterinary Internal Medicine 30(2): 536-42, Mar 2016.

Solter Philip F, Oyama Mark A, Machen Maggie C, Trafny Dennis J, Sisson D David: Detection by ELISA of C-terminal proBNP in plasma from cats with cardiomyopathy. Veterinary journal (London, England : 1997) 206(2): 213-7, Nov 2015.

Pouchelon J L, Atkins C E, Bussadori C, Oyama M A, Vaden S L, Bonagura J D, Chetboul V, Cowgill L D, Elliot J, Francey T, Grauer G F, Fuentes V Luis, Moise N Sydney, Polzin D J, Van Dongen A M, Van Israƫl N: Cardiovascular-renal axis disorders in the domestic dog and cat: a veterinary consensus statement. The Journal of small animal practice 56(9): 537-52, Sep 2015.

Oyama Mark A: Perioperative Monitoring of Heart Rate and Rhythm. The Veterinary clinics of North America. Small animal practice 45(5): 953-63, Sep 2015.

Oyama Mark A: Using Cardiac Biomarkers in Veterinary Practice. Clinics in laboratory medicine 35(3): 555-66, Sep 2015.

Cremer S E, Moesgaard S G, Rasmussen C E, Zois N E, Falk T, Reimann M J, Cirera S, Aupperle H, Oyama M A, Olsen L H: Alpha-smooth muscle actin and serotonin receptors 2A and 2B in dogs with myxomatous mitral valve disease. Research in veterinary science 100: 197-206, Jun 2015.

Cremer, Signe E; Kristensen, Annemarie T; Reimann, Maria J; Eriksen, Nynne B; Petersen, Stine F; Marschner, Clara B; Tarnow, Inge; Oyama, Mark A; Olsen, Lisbeth H.: Plasma and serum serotonin concentrations and surface-bound platelet serotonin expression in Cavalier King Charles Spaniels with myxomatous mitral valve disease. American Journal of Veterinary Research 76(6): 520-31, Jun 2015.

Cremer S E, Zois N E, Moesgaard S G, Ravn N, Cirera S, Honge J L, Smerup M H, Hasenkam J M, Sloth E, Leifsson P S, Falk T, Oyama M A, Orton C, Martinussen T, Olsen L H: Serotonin markers show altered transcription levels in an experimental pig model of mitral regurgitation. Veterinary journal (London, England : 1997) 203(2): 192-8, Feb 2015.

Fox, P R; Oyama, M A; Hezzell, M J; Rush, J E; Nguyenba, T P; DeFrancesco, T C; Lehmkuhl, L B; Kellihan, H B; Bulmer, B; Gordon, S G; Cunningham, S M; MacGregor, J; Stepien, R L; Lefbom, B; Adin, D; Lamb, K.: Relationship of plasma N-terminal pro-brain natriuretic peptide concentrations to heart failure classification and cause of respiratory distress in dogs using a 2nd generation ELISA assay. Journal of Veterinary Internal Medicine 29(1): 171-9, Jan 2015.

Machen, Maggie C; Oyama, Mark A; Gordon, Sonya G; Rush, John E; Achen, Sarah E; Stepien, Rebecca L; Fox, Philip R; Saunders, Ashley B; Cunningham, Suzanne M; Lee, Pamela M; Kellihan, Heidi B.: Multi-centered investigation of a point-of-care NT-proBNP ELISA assay to detect moderate to severe occult (pre-clinical) feline heart disease in cats referred for cardiac evaluation. Journal of Veterinary Cardiology 16(4): 245-55, Dec 2014.

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Last updated: 06/28/2017
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