Muredach P. Reilly

faculty photo
Professor of Medicine
Associate Scholar, Center for Clinical Epidemiology and Biostatistics (CCEB), University of Pennsylvania, School of Medicine
Attending Cardiologist, Hospital of the University of Pennsylvania
Associate Director, Cardiovascular Fellowship Program, University of Pennsylvania
Department: Medicine

Contact information
Translational Research Center
3400 Civic Center Blvd, Bldg 421
11th Floor, Room 11-136
Philadelphia, PA 19104
Office: (215) 573-1214
Lab: (215) 573-0224
Graduate Group Affiliations
Education:
MBBCh (Medicine)
University College, Dublin, Ireland, 1988.
BS (Pharmacology)
University College Dublin, Ireland , 1990.
MSCE (Epidemiology and Biostatistics)
University of Pennsylvania, 2003.
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Description of Research Expertise

My group focuses on preclinical cell and rodent translational modeling, human cardiometabolic disease, as well as human genomics and epidemiology. I have a track record of translational, genomic and biomarker studies in heart and metabolic disease as well as in assembling multidisciplinary teams for execution of translational and genomic research. At this conference, I will present data on the genomics of coronary artery disease and myocardial infarction.

Description of Itmat Expertise

Dr Reilly's interests include (1) mechanisms of atherosclerosis in metabolic syndrome, diabetes and obesity, (2) the role on innate immunity in promoting atherosclerotic risk in metabolic syndrome, (3) the functions of adipose tissue in regulation of HDL cholesterol and reverse cholesterol transport, (4) genetics of atherosclerosis and dyslipidemia in high risk populations including type 2 diabetes, subjects with family history of CAD, populations with chronic kidney disease and in HIV infected populations, and (5) non-invasive imaging of atherosclerosis in humans.

Selected Publications

Schick UM, Auer PL, Bis JC, Lin H, Wei P, Pankratz N, Lange LA, Brody J, Stitziel NO, Kim DS, Carlson CS, Fornage M, Haessler J, Hsu L, Jackson RD, Kooperberg C, Leal SM, Psaty BM, Boerwinkle E, Tracy R, Ardissino D, Shah S, Willer C, Loos R, Melander O, Mcpherson R, Hovingh K, Reilly M, Watkins H, Girelli D, Fontanillas P, Chasman DI, Gabriel SB, Gibbs R, Nickerson DA, Kathiresan S, Peters U, Dupuis J, Wilson JG, Rich SS, Morrison AC, Benjamin EJ, Gross MD, Reiner AP: Association of exome sequences with plasma C-reactive protein levels in >9000 participants. Hum Mol Genet 24((2)): 559 -71, Jan 2015 Notes: Cohorts for Heart and Aging Research in Genomic Epidemiology and the National Heart, Lung, and Blood Institute GO Exome Sequencing Project.

Khera AV, Qamar A, Reilly MP, Dunbar RL, Rader DJ.: Effects of niacin, statin, and fenofibrate on circulating proprotein convertase subtilisin/kexin type 9 levels in patients with dyslipidemia. Am J Cardiol. 2015 Jan 15;115(2):178-82. doi: 10.1016/j.amjcard.2014.10.018. Epub 2014 Oct 31. Jan 2015.

Walley KR, Thain KR, Russell JA, Reilly MP, Meyer NJ, Ferguson JF, Christie JD, Nakada TA, Fjell CD, Thair SA, Cirstea MS, Boyd JH.: PCSK9 is a critical regulator of the innate immune response and septic shock outcome. Sci Transl Med. 6(258), October 2014

Yoneyama S(1), Guo Y, Lanktree MB, Barnes MR, Elbers CC, Karczewski KJ, Padmanabhan S, Bauer F, Baumert J, Beitelshees A, Berenson GS, Boer JM, Burke G, Cade B, Chen W, Cooper-Dehoff RM, Gaunt TR, Gieger C, Gong Y, Gorski M, Heard-Costa N, Johnson T, Lamonte MJ, McDonough C, Monda KL, Onland-Moret NC, Nelson CP, O'Connell JR, Ordovas J, Peter I, Peters A, Shaffer J, Shen H, Smith E, Speilotes L, Thomas F, Thorand B, Monique Verschuren WM, Anand SS, Dominiczak A, Davidson KW, Hegele RA, Heid I, Hofker MH, Huggins GS, Illig T, Johnson JA, Kirkland S; Look AHEAD Research Group, K├Ânig W, Langaee TY, McCaffery J, Melander O, Mitchell BD, Munroe P, Murray SS, Papanicolaou G, Redline S, Reilly M, Samani NJ, Schork NJ, Van Der Schouw YT, Shimbo D, Shuldiner AR, Tobin MD, Wijmenga C, Yusuf S; GIANT Consortium; CARe IBC Consortium, Hakonarson H, Lange LA, Demerath EW, Fox CS, North KE, Reiner AP, Keating B, Taylor KC.: Gene-centric meta-analyses for central adiposity traits in up to 57 412 individuals of European descent confirm known loci and reveal several novel associations. Hum Mol Genet. 23(9): 2498-510, May 2014

Wing MR(1), Yang W, Teal V, Navaneethan S, Tao K, Ojo A, Guzman NN, Reilly M, Wolman M, Rosas SE, Cuevas M, Fischer M, Lustigova E, Master SR, Xie D, Appleby D, Joffe M, Kusek J, Feldman HI, Raj DS; Chronic Renal Insufficiency Cohort (CRIC) Study.: Race modifies the association between adiposity and inflammation in patients with chronic kidney disease: findings from the chronic renal insufficiency cohort study. Obesity (Silver Spring). 22(5): 1359-66, May 2014

Lin J, Reilly MP, Terembula K, Wilson FP. : Plasma Lipoprotein(a) Levels Are Associated with Mild Renal Impairment in Type 2 Diabetics Independent of Albuminuria. PLoS One. 2014 Dec 9;9(12):e114397. doi: 10.1371/journal.pone.0114397. eCollection 2014. Dec 2014.

Martin SS, Blaha MJ, Muse ED, Qasim AN, Reilly MP, Blumenthal RS, Nasir K, Criqui MH, McClelland RL, Hughes-Austin JM, Allison MA.: Leptin and incident cardiovascular disease: The Multi-Ethnic Study of Atherosclerosis (MESA). Atherosclerosis 239((1)): 67 - 72, Dec 2014.

Ferguson JF, Ryan M, Gibney E, Brennan L, Roche HM, Reilly MP.: Dietary isoflavone intake is associated with evoked responses to inflammatory cardiometabolic stimuli and improved glucose homeostasis in healthy volunteers Nutr Metab Cardiovasc Dis. 24(9): 996-1003, September 2014.

Meyer NJ, Ferguson JF, Feng R, Wang F, Patel PN, Li M, Xue C, Qu L, Liu Y, Boyd JH, Russell JA, Christie JD, Walley KR, Reilly MP.: A Functional Synonymous Coding Variant in the IL1RN Gene Associates with Survival in Septic Shock. Am J Respir Crit Care Med. 190(6): 656-64, September 2014.

Mehta1 NN, Matthews G, Krishnamoorthy P, Shah R, McLaughlin C, Patel P, Budoff M, Chen J, Wolman M, Go A, He J, Kanetsky PA, Master SM, Rader DJ, Raj D, Gadegbeku CA, Shah R, Schreiber M, Fischer MJ, Townsend RR, Kusek J, Feldman HI, Foulkes AS, Reilly MP, and the Chronic Renal Insufficiency Cohort (CRIC) Study Investigators.: Higher plasma CXCL12 levels predict incident myocardial infarction and death in chronic kidney disease: Findings from the Chronic Renal Insufficiency Cohort Study. Eur Heart J. 35(31): 2115-22, August 2014.

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Last updated: 04/17/2015
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