Enrico Radaelli
Associate Professor, Pathobiology, University of Pennsylvania School of Veterinary Medicine
Contact information
Penn Vet, Ryan Veterinary Hospital
3900 Delancey Street
Philadelphia, PA 19104
3900 Delancey Street
Philadelphia, PA 19104
Office: 2158984523
Email:
enrada@vet.upenn.edu
enrada@vet.upenn.edu
Publications
Education:
DVM (Veterinary Medicine)
University of Milan (Italy) School of Veterinary Medicine, 2004.
PhD (Veterinary Hygiene & Comparative Animal Pathology)
University of Milan (Italy) School of Veterinary Medicine, 2010.
Permanent linkDVM (Veterinary Medicine)
University of Milan (Italy) School of Veterinary Medicine, 2004.
PhD (Veterinary Hygiene & Comparative Animal Pathology)
University of Milan (Italy) School of Veterinary Medicine, 2010.
Description of Itmat Expertise
Pathobiology of animal modelsPhenotyping of genetically engineered mouse (GEM) models
Comparative pathology
Description of Research Expertise
Pathobiology of animal modelsPhenotyping of genetically engineered mouse (GEM) models
Comparative pathology
Selected Publications
Acx Hermien, Serneels Lutgarde, Radaelli Enrico, Muyldermans Serge, Vincke Cécile, Pepermans Elise, Müller Ulrike, Chávez-Gutiérrez Lucía, De Strooper Bart: Inactivation of γ-secretases leads to accumulation of substrates and non-Alzheimer neurodegeneration. EMBO molecular medicine 9(8): 1088-1099, Aug 2017.Castiello Maria Carmina, Pala Francesca, Sereni Lucia, Draghici Elena, Inverso Donato, Sauer Aisha V, Schena Francesca, Fontana Elena, Radaelli Enrico, Uva Paolo, Cervantes-Luevano Karla E, Benvenuti Federica, Poliani Pietro L, Iannacone Matteo, Traggiai Elisabetta, Villa Anna, Bosticardo Marita: In Vivo Chronic Stimulation Unveils Autoreactive Potential of Wiskott-Aldrich Syndrome Protein-Deficient B Cells. Frontiers in immunology 8: 490, 2017.
Espuny-Camacho Ira, Arranz Amaia M, Fiers Mark, Snellinx An, Ando Kunie, Munck Sebastian, Bonnefont Jerome, Lambot Laurie, Corthout Nikky, Omodho Lorna, Vanden Eynden Elke, Radaelli Enrico, Tesseur Ina, Wray Selina, Ebneth Andreas, Hardy John, Leroy Karelle, Brion Jean-Pierre, Vanderhaeghen Pierre, De Strooper Bart: Hallmarks of Alzheimer's Disease in Stem-Cell-Derived Human Neurons Transplanted into Mouse Brain. Neuron 93(5): 1066-1081.e8, Mar 2017.
Dagklis Antonis, Demeyer Sofie, De Bie Jolien, Radaelli Enrico, Pauwels Daphnie, Degryse Sandrine, Gielen Olga, Vicente Carmen, Vandepoel Roel, Geerdens Ellen, Uyttebroeck Anne, Boeckx Nancy, de Bock Charles E, Cools Jan: Hedgehog pathway activation in T-cell acute lymphoblastic leukemia predicts response to SMO and GLI1 inhibitors. Blood 128(23): 2642-2654, Dec 2016.
Radaelli E, Castiglioni V, Recordati C, Gobbi A, Capillo M, Invernizzi A, Scanziani E, Marchesi F: The Pathology of Aging 129S6/SvEvTac Mice. Veterinary pathology 53(2): 477-92, Mar 2016.
Leucci Eleonora, Vendramin Roberto, Spinazzi Marco, Laurette Patrick, Fiers Mark, Wouters Jasper, Radaelli Enrico, Eyckerman Sven, Leonelli Carina, Vanderheyden Katrien, Rogiers Aljosja, Hermans Els, Baatsen Pieter, Aerts Stein, Amant Frederic, Van Aelst Stefan, van den Oord Joost, de Strooper Bart, Davidson Irwin, Lafontaine Denis L J, Gevaert Kris, Vandesompele Jo, Mestdagh Pieter, Marine Jean-Christophe: Melanoma addiction to the long non-coding RNA SAMMSON. Nature 531(7595): 518-22, Mar 2016.
Adriaens Carmen, Standaert Laura, Barra Jasmine, Latil Mathilde, Verfaillie Annelien, Kalev Peter, Boeckx Bram, Wijnhoven Paul W G, Radaelli Enrico, Vermi William, Leucci Eleonora, Lapouge Gaëlle, Beck Benjamin, van den Oord Joost, Nakagawa Shinichi, Hirose Tetsuro, Sablina Anna A, Lambrechts Diether, Aerts Stein, Blanpain Cédric, Marine Jean-Christophe: p53 induces formation of NEAT1 lncRNA-containing paraspeckles that modulate replication stress response and chemosensitivity. Nature medicine 22(8): 861-8, Aug 2016.
Gallardo Rodrigo, Ramakers Meine, De Smet Frederik, Claes Filip, Khodaparast Ladan, Khodaparast Laleh, Couceiro José R, Langenberg Tobias, Siemons Maxime, Nyström Sofie, Young Laurence J, Laine Romain F, Young Lydia, Radaelli Enrico, Benilova Iryna, Kumar Manoj, Staes An, Desager Matyas, Beerens Manu, Vandervoort Petra, Luttun Aernout, Gevaert Kris, Bormans Guy, Dewerchin Mieke, Van Eldere Johan, Carmeliet Peter, Vande Velde Greetje, Verfaillie Catherine, Kaminski Clemens F, De Strooper Bart, Hammarström Per, Nilsson K Peter R, Serpell Louise, Schymkowitz Joost, Rousseau Frederic: De novo design of a biologically active amyloid. Science (New York, N.Y.) 354(6313), 11 2016.
Castiglioni V, Farhang Ghahremani M, Goossens S, De Maglie M, Ardizzone M, Haigh J J, Radaelli E: Immunohistological Description of Nongestational Ovarian Choriocarcinoma in Two Female Mice With Conditional Loss of Trp53 Driven by the Tie2 Promoter. Veterinary pathology 52(4): 752-6, Jul 2015.
Radaelli Enrico, Hermans Els, Omodho Lorna, Francis Annick, Vander Borght Sara, Marine Jean-Christophe, van den Oord Joost, Amant Frédéric: Spontaneous Post-Transplant Disorders in NOD.Cg- Prkdcscid Il2rgtm1Sug/JicTac (NOG) Mice Engrafted with Patient-Derived Metastatic Melanomas. PloS one 10(5): e0124974, 2015.