Michael D. Hogarty

faculty photo
Associate Professor of Pediatrics at the Children's Hospital of Philadelphia
Member, Abramson Cancer Center
Assistant Member, The Children's Hospital of Philadelphia Research Institute
Member, Institute for Translational Medicine and Therapeutics, University of Pennsylvania
Director, Physician Scientist Program, The Children's Hospital of Philadelphia
Department: Pediatrics

Contact information
Division of Oncology
The Children's Hospital of Philadelphia
Colket Translational Research Building, Room 3020
3501 Civic Center Boulevard
Philadelphia, PA 19104-4318
Office: 215-590-3931
Fax: 215-590-3770
Lab: 215-590-9930
Education:
B.E.S. (Biomedical Engineering)
Johns Hopkins University, Baltimore, MD, 1986.
M.D. (Medicine)
Columbia University College of Physicians and Surgeons, New York, NY, 1990.
Permanent link
 

Description of Itmat Expertise

The Hogarty lab works on defining the cancer biopathways that support neuroblastoma tumourigenesis with particular focus on understanding how neuroblasts with MYCN amplification avoid engaging the latent apoptosis programs usually activated with dergulated oncogene activity. We study experimental therapeutics targeting key neuroblast survival pathways.

Selected Publications

Suganuma Rie, Wang Larry L, Sano Hideki, Naranjo Arlene, London Wendy B, Seeger Robert C, Hogarty Michael D, Gastier-Foster Julie M, Look A Thomas, Park Julie R, Maris John M, Cohn Susan L, Amann Gabriele, Beiske Klaus, Cullinane Catherine J, d'Amore Emanuele S G, Gambini Claudio, Jarzembowski Jason A, Joshi Vijay V, Navarro Samuel, Peuchmaur Michel, Shimada Hiroyuki: Peripheral neuroblastic tumors with genotype-phenotype discordance: A report from the Children's Oncology Group and the International Neuroblastoma Pathology Committee. Pediatric blood & cancer 60(3): 363-70, Mar 2013.

Boiani Mariana, Daniel Cristina, Liu Xueyuan, Hogarty Michael D, Marnett Lawrence J: The stress protein BAG3 stabilizes Mcl-1 and promotes survival of cancer cells and resistance to ABT-737. The Journal of biological chemistry Jan 2013.

Pugh Trevor J, Morozova Olena, Attiyeh Edward F, Asgharzadeh Shahab, Wei Jun S, Auclair Daniel, Carter Scott L, Cibulskis Kristian, Hanna Megan, Kiezun Adam, Kim Jaegil, Lawrence Michael S, Lichenstein Lee, McKenna Aaron, Pedamallu Chandra Sekhar, Ramos Alex H, Shefler Erica, Sivachenko Andrey, Sougnez Carrie, Stewart Chip, Ally Adrian, Birol Inanc, Chiu Readman, Corbett Richard D, Hirst Martin, Jackman Shaun D, Kamoh Baljit, Khodabakshi Alireza Hadj, Krzywinski Martin, Lo Allan, Moore Richard A, Mungall Karen L, Qian Jenny, Tam Angela, Thiessen Nina, Zhao Yongjun, Cole Kristina A, Diamond Maura, Diskin Sharon J, Mosse Yael P, Wood Andrew C, Ji Lingyun, Sposto Richard, Badgett Thomas, London Wendy B, Moyer Yvonne, Gastier-Foster Julie M, Smith Malcolm A, Auvil Jaime M Guidry, Gerhard Daniela S, Hogarty Michael D, Jones Steven J M, Lander Eric S, Gabriel Stacey B, Getz Gad, Seeger Robert C, Khan Javed, Marra Marco A, Meyerson Matthew, Maris John M: The genetic landscape of high-risk neuroblastoma. Nature genetics Jan 2013.

Qing G, Li B, Vu A, Skuli N, Walton ZE, Liu X, Mayes PA, Wise DR, Thompson CB, Maris JM, Hogarty MD, Simon MC.: ATF4 regulates MYC-mediated neuroblastoma cell death upon glutamine deprivation. Cancer Cell 22(5): 631-44, Nov 2012.

Goldsmith KC, Gross M, Pierce S, Luyindula D, Liu X, Vu A, Sliozberg M, Guo R, Zhao H, Reynolds CP, Hogarty MD. : Mitochondrial Bcl-2 family dynamics define therapy response and resistance in neuroblastoma. Cancer Research 72(10): 2565-77, May 2012.

Hogarty Michael D, Maris John M: PI3King on MYCN to improve neuroblastoma therapeutics. Cancer cell 21(2): 145-7, Feb 2012.

Sausen M, Leary RJ, Jones S, Wu J, Reynolds CP, Liu X, Blackford A, Parmigiani G, Diaz Jr LA, Papadopoulos N, Vogelstein B, Kinzler KW, Velculescu VE, Hogarty MD. : Integrated genomic analyses identify ARID1A and ARID1B alterations in the childhood cancer neuroblastoma. Nature Genetics 45(1): 12-7, Jan 2012.

Dubois Steven G, Geier Ethan, Batra Vandana, Yee Sook Wah, Neuhaus John, Segal Mark, Martinez Daniel, Pawel Bruce, Yanik Greg, Naranjo Arlene, London Wendy B, Kreissman Susan, Baker David, Attiyeh Edward, Hogarty Michael D, Maris John M, Giacomini Kathleen, Matthay Katherine K: Evaluation of Norepinephrine Transporter Expression and Metaiodobenzylguanidine Avidity in Neuroblastoma: A Report from the Children's Oncology Group. International journal of molecular imaging 2012: 250834, 2012.

De Preter Katleen, Mestdagh Pieter, Vermeulen Joëlle, Zeka Fjoralba, Naranjo Arlene, Bray Isabella, Castel Victoria, Chen Caifu, Drozynska Elzbieta, Eggert Angelika, Hogarty Michael D, Izycka-Swieszewska Ewa, London Wendy B, Noguera Rosa, Piqueras Marta, Bryan Kenneth, Schowe Benjamin, van Sluis Peter, Molenaar Jan J, Schramm Alexander, Schulte Johannes H, Stallings Raymond L, Versteeg Rogier, Laureys Geneviève, Van Roy Nadine, Speleman Frank, Vandesompele Jo: miRNA expression profiling enables risk stratification in archived and fresh neuroblastoma tumor samples. Clinical cancer research : an official journal of the American Association for Cancer Research 17(24): 7684-92, Dec 2011.

Liu Grant T, Mahoney Nicholas R, Avery Robert A, Menacker Sheryl J, Wilson Martin C, Hogarty Michael D, Maris John M: Pediatric horner syndrome. Archives of ophthalmology 129(8): 1108-9; author reply 1109, Aug 2011.

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Last updated: 04/11/2014
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