KRZYSZTOF P. WROBLEWSKI, Ph.D.

Professor of Biochemistry and Biophysics
Director, Center for Biomedical NMR
Member of the New York Academy of Sciences
 Address:
University of Pennsylvania School of Medicine
Rm. 96 John Morgan Building
Philadelphia, PA 19104-6112
Tel: (215) 898-6396
Fax: (215) 898-5642
Email: krzyszto@mail.med.upenn.edu

DESCRIPTION OF RESEARCH INTERESTS:

  1. Multinuclear NMR spectroscopy focusing on intracellular signaling, metabolic control, and ion transport.
  2. Structure and conformation of peptides, oligosaccharides, and glycopeptides using two and three-dimensional NMR spectroscopy.
  3. Hyperpolarized Carbon, Helium, and Xenon enhanced MRI.
  4. Clinical Informatics
  5. Artificial Intelligence and Fetal Echoanalysis

REPRESENTATIVE PUBLICATIONS (selected from over 100 publications)

  1. Rozmyslowicz T., Wroblewski K., Moodley J., Gaulton G. A Decrease in the Cellular Phosphodiester to Phosphomonoester Lipid Ratio is Characteristic of HIV-1 Infection. Current HIV Research 8: 355-363 (2010).
  2. Wroblewski K., Spalthoff S., Zimmerman U.J., Sanger J.W., Forster R.E., Inhibition of Carbonic Anhydrase Retards the Recovery of pH and Phosphocreatine after a Period of Ischemia in Superfused Newborn Rabbit Myotubes and Mouse Soleus Cell Line H-2Kb-ts-A58. J.Appl.Physiol. 99: 488-498 (2005).
  3. Rozmyslowicz T., Conover D.O., Murphy S.L., Ratajczak M.Z., Wroblewski K., Gaulton G.N. Novel Mechanisms of HIV-1 Infection and Pathogenesis. Acta Haematologica Polonica 34: 211-220 (2003).
  4. Wroblewski K. E-learning and Fetal Cardiology. in: Problemy Kardiologiczne i Badania Dopplera u Plodu. edited by Maria Respondek-Liberska Vol. 3, p. 83-88, Wydawnictwo Adi, Lodz 2003.
  5. Dimitrov I,E., Poptani H., Wroblewski K., Leigh J.S. 129Xe Spectroscopy of Normal and Tumor Tissues. Proc. Intl. Soc. Mag. Reson. Med. 10: 1471 (2002).
  6. Noyszewski E.A., Wroblewski, K., Dodge, G.R., Kudchodkar S., Beers J., Sarma A.V.S., Reddy R. Preferential Incorporation of Glucosamine Into the Galactosamine Moieties of Chondroitin Sulfates in Articular Cartilage Explants. Arthritis & Rheumatism 44: 1089-1095 (2001).
  7. Niibori K., Wroblewski, K., Yokohama H., Crestanello J., Whitman G.J., Bioenegetic Effect of Liposomal Coenzyme Q10 on Myocardial Ischemia Reperfusion Injury. Biofactors 9: 307-313 (1999).
  8. Wroblewski K. Computer Supported Decision in Fetal Echocardiography. in: Problemy Kardiologiczne i Badania Dopplera u Plodu - edited by Maria Respondek-Liberska, Vol. 1, p. 39-44, Wydawnictwo Adi, Lodz 1999.
  9. Doliba N., Doliba N.M, Chang Q., Babsky A.M., Wroblewski K., Natelson B.H., Osbakken M.D. M Mitochondrial Oxidative Phosphorylation in Heart from Stressed Cardiomyopathic Hamsters J.Mol.Cell.Cardiol. 31: 543-553 (1999).
  10. Biaglow J.E., Manevich Y., Leeper D., Chance B., Dewhirst M., Jenkins W.T., Tutle S., Wroblewski K., Glickson J.D., Stevens C., Evans S.M. MIBG Inhibits Respiration: Potenbtial for Radio- and Hyperthermic Sensitization. Int. J.Radiat.Oncol., Biol., Phys. 42: 871-876 (1998).
  11. Pavlovic M., Wroblewski K., Manevich Y., Kim S., Biaglow J.E. The importance of choice of anaesthetics in studying radiation effects in the 9L rat glioma. Br.J.Cancer 74:222-225 (1996).
  12. Wroblewski K., Tian Z.Y., Wroblewski P.M. Fetal Echocardiography Homepage in: Internet Resources for Cardiology. Edited by Ryozo Nagai, p.114-131, BIOMEDIS, Tokyo 1996.
  13. Ivanics T., Blum, H., Wroblewski, K., Wang D., Osbakken M.: Intracellular Sodium in Cardiomyocytes using 23Na NMR. Biochem. Biophys. Acta 1221:133-144, (1994).
  14. Urge, L., Jackson D.C., Graczyk G., Otvos L., Wroblewski, K.: Synthesis and Conformational Analysis of N-glycopeptides that Contain Extended Sugar Chains, Tetrahedron 50:2373-2390 (1994).
  15. Osbakken, M., Wroblewski, K., Zhang, D., Ivanics, T., Wehrli, S.: Adenosine Triphosphate Relaxation Rate to Evaluate Ischemic Events in the Heart, Magn. Res. Med. 30:498-503 (1993).