PennSIVE

Image Prediction

Disruption of the blood-brain barrier (BBB) in multiple sclerosis (MS) signifies the presence of active inflammation and is associated with the development of new lesions and clinical relapses. It is most commonly detected as enhancement on MR imaging performed with contrast agents that are costly and occasionally toxic.

We demonstrated that the presence of a disrupted BBB can be predicted from unenhanced MR imaging data in patients with confirmed MS and that this information can be extracted by using standard statistical techniques.

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In the future, we hope to refine these techniques both in multiple sclerosis and in other diseases as imaging becomes a more common and important measure of disease progression.

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