Faculty

John H. Holmes, PhD, FACE, FACMI, FIAHSI

Professor of Medical Informatics in Epidemiology in Biostatistics and Epidemiology at the Hospital of the University of Pennsylvania

Department: Biostatistics and Epidemiology

Graduate Group Affiliations

Contact information

401 Blockley Hall
423 Guardian Drive
Philadelphia, PA 19104

Office: 215-898-4833
Fax: 215-573-5325

Email:
jhholmes@pennmedicine.upenn.edu

Publications

Search PubMed for articles

Education:
A.B. (Sociology)
University of Pennsylvania, 1976.
M.S. (Information Systems)
Drexel University, 1987.
Ph.D. (Information Science)
Drexel University, 1996.

Links
Search PubMed for articles
Center for Clinical Epidemiology and Biostatistics faculty

Permanent link

> Perelman School of Medicine > Faculty > Details

Description of Research Expertise

medical informatics; data mining; evolutionary computation; machine learning; artificial intelligence; database design and implementation for clinical research; medical decision making;

Selected Publications

Sultan L, Venkatakrishna SSB, Anupindi S, Andronikou S, Acord M, Otero H, Holmes JH: ChatGPT-4-Driven Liver Ultrasound Radiomics Analysis: Advantages and Drawbacks Compared to Traditional Techniques. JMIR AI doi:10.2196/68144 2025.

Skarke C, Yang W, Sha D, Lahens NF, Isakova T, Unruh M, Deo R, Carmona-Powell E, Holmes JH, Ficarra E, Chen J, Jiang He, Rincon-Choles H, Shah V, Hsu CY, Anderson AH, Lash JP, Rahman M: A multi-center study to discern the diurnal variation of wearable device-based heart rate variability (HRV) in the Chronic Renal Insufficiency Cohort (CRIC) Study. medRxiv doi:10.1101/2025.04.30.25326177 2025.

Beidler E, Teel E, Schmitt AJ, Muccio G, Holmes JH, Bretzin AC: Anxiety-Related Concussion Perceptions of Parents of Youth Athletes. Journal of Athletic Training Dec 2024.

Moutchia J, McClelland RL, Al-Naamani N, Appleby, Holmes JH, Minhas J, Mazurek JA, Palevsky HI, Ventetuolo CE, Kawut SM: Pulmonary arterial hypertension treatment: an individual participant data network meta-analysis. European Heart Journal Page: ehae049, Feb 2024.

Getzen E, Tan AL, Brat G, Omenn GS, Strasser Z; Consortium for Clinical Characterization of COVID-19 by EHR (4CE) (Collaborative Group/Consortium); Long Q, Holmes JH, Mowery D: Leveraging informative missing data to learn about acute respiratory distress syndrome and mortality in long-term hospitalized COVID-19 patients throughout the years of the pandemic. AMIA Annu Symp Proc Page: 942-950, Jan 2024.

Minhas J, Moutchia J, Al-Naamani N, Mazurek JA, Holmes JH, Appleby D, Smith KA, Fritz JS, Pugliese SC, Palevsky HI, Kawut SM: Electrocardiographic Abnormalities and Their Association with Outcomes in Randomized Clinical Trials of Pulmonary Arterial Hypertension. Ann Am Thorac Soc Jan 2024.

Bretzin AC, Schmitt AJ, Teel E, Holmes JH, Wiebe DJ, Beidler E: Parent and Youth Athlete Perceptions of Concussion Injury: Establishing a Factor Structure. Arch Clin Neuropsychol Jan 2024.

Dixon BE, Holmes JH: Special Section on Digital Health for Precision in Prevention: Notable Papers that Leverage Informatics Approaches to Support Precision Prevention Efforts in Health Systems. nternational Medical Informatics Association Yearbook of Medical Informatics 33(1): 70-72, 2024.

Motlhatlhedi K, Tsima BM, Xie D, Wiebe D, Holmes JH: Risk factors for the most common pediatric unintentional injury admissions in a rural district hospital- Botswana Society for EPidemiologic Research 2024 Annual Meeting 2024.

Sperotto F, Gutiérrez-Sacristán A, Makwana S, Li X, Rofeberg VN, Cai T, Bourgeois FT, Omenn GS, Hanauer DA, Sáez C, Bonzel CL, Bucholz E, Dionne A, Elias MD, García-Barrio N, González TG, Issitt RW, Kernan KF, Laird-Gion J, Maidlow SE, Mandl KD, Ahooyi TM, Moraleda C, Morris M, Moshal KL, Pedrera-Jiménez M, Shah MA, South AM, Spiridou A, Taylor DM, Verdy G, Visweswaran S, Wang X, Xia Z, Zachariasse JM; Consortium for Clinical Characterization of COVID-19 by EHR (4CE); Newburger JW, Avillach P: Clinical phenotypes and outcomes in children with multisystem inflammatory syndrome across SARS-CoV-2 variant eras: a multinational study from the 4CE consortium. The Lancet eClinicalMedicine 64: 102212, Sep 2023.