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Roy Hoshi Hamilton, MD, MS, FAAN, FANA

Professor of Neurology
Director, Laboratory for Cognition and Neural Stimulation, University of Pennsylvania
Faculty, Center for Neuroscience and Society, University of Pennsylvania
Co-Director, Penn Minority Scholars in Aging Research Program, University of Pennsylvania
Diversity Search Advisor, Department of Neurology, University of Pennsylvania
Director, Brain Stimulation, Translation, Innovation, and Modulation (brainSTIM) Center, University of Pennsylvania
Faculty, Brain Science Center, University of Pennsylvania
Advisory Board Member, Clinical Neurosciences Training Program (CNST), Perelman School of Medicine, University of Pennsylvania
Vice Dean for Inclusion, Diversity, and Equity, Perelman School of Medicine, University of Pennsylvania
Department: Neurology

Contact information
Goddard Laboratories, Room 518
University of Pennsylvania
3710 Hamilton Walk
Philadelphia, PA 19104
Office: 215-573-7065
Fax: 215-898-1982
Graduate Group Affiliations
B.A. (Psychology, magna cum laude)
Harvard University, 1995.
M.D. (Medicine, cum laude)
Harvard Medical School, 2001.
M.S. (Health Sciences and Technology)
Massachusetts Institute of Technology , 2001.
Post-Graduate Training
Intern in Internal Medicine, University of California School of Medicine, Los Angeles, 2001-2002.
Resident in Neurology, University of Pennsylvania, 2002-2005.
Fellow in Cognitive Neurology, University of Pennsylvania, 2005-2007.
American Board of Psychiatry and Neurology, 2006.
American Board of Psychiatry and Neurology, Maintenance of Certification (MOC), 2016.
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Description of Research Expertise

My research focus is on the characteristics and limits of functional neuroplasticity in the adult human brain. I investigate how the brain reorganizes itself in response to injury, and whether or not it is possible to enhance the brain’s potential for reorganization in order to speed rehabilitation using noninvasive electrical or magnetic brain stimulation. A second area of interest for me is on the use of noninvasive brain stimulation to elucidate and enhance mechanisms of cognition in healthy individuals, and the biological, social, and ethical implications of neural enhancement.

Description of Clinical Expertise

I principally treat patients suffering from dementia. I also have expertise in evaluating and treating patients with cognitive deficits following stroke.

Description of Other Expertise

I am is deeply involved in issues related to diversity in medicine, inclusion, and health equity. I am one of the Assistant Deans for Diversity and Inclusion at the Perelman School of Medicine and I am the Vice Chair for Diversity and Inclusion in the Department of Neurology at the University of Pennsylvania.

Selected Publications

Baldwin, A., Copeland, J., Azage, M., Dratch, L., Johnson, K., Paul, R.A., Amado, D.A., Baer, M., Deik, A.F., Elman, L.B., Guo, M.H., Hamedani, A.G., Irwin, D.J., Lasker, A., Orthmann-Murphy, J., Quinn, C., Tropea, T.F., Scherer, S.S., Shinohara, R.T., Hamilton, R.H., Ellis, C.A.: Disparities in genetic testing for neurologic disorders. Neurology Mar 2024.

Deck, B., Kelkar, A., Erickson, B., Erani, F., McConathey, E., Sacchetti, D., Faseyitan, O.K., Hamilton, R.H., Medaglia, J.D.: Individual-level functional connectivity predicts cognitive control efficiency. NeuroImage(283), 120386, Dec 2023.

Sloane, K.L., Kasner, S.E., Favilla, C.G., Rothstein, A., Witsch, J., Hamilton, R.H., Schneider, A.L.C.: Always look on the bright side: Associations of optimism with functional outcomes after stroke. Journal of the American Heart Association (JAHA) 12(5), Mar 2023.

Nissim, N.R., McAfee, D.C., Prato, B.S., Lin, J., Lu, Z., Coslett, H.B., Hamilton, R.H. : Efficacy of tACS in the enhancement of working memory performance in healthy adults: a systematic meta-analysis. Neuromodulation: Technology at the Neural Interface Feb 2023.

Ambron, E., Goldstein, S., Miller, A., Hamilton, R.H., Coslett, H.B. : From my skin to your skin: Virtual image of a hand of different skin color influences movement duration of the real hand in Black and White individuals and influences racial bias. Frontiers in Virtual Reality Page:, Dec 2022.

Fareshte, E., Darshan, P., Deck, B.L., Hamilton, R.H., Schultheis, M.T., Medaglia, J.D.: Investigating the influence of an effort-reward interaction on cognitive fatigue in individuals with multiple sclerosis. Journal of Neuropsychology Page: doi: 10.1111/jnp.12295, Oct 2022.

Cember, A.T.J., Deck, B.L., Kelkar, A., Faseyitan, O., Zimmerman, J.P., Erickson, B., Elliott, M.A., Coslett, H.B., Hamilton, R.H., Reddy, R., Medaglia, J.D. : Glutamate-Weighted Magnetic Resonance Imaging (GluCEST) Detects Effects of Transcranial Magnetic Stimulation to the Motor Cortex. Neuroimage 256: 119191, Aug 2022 Notes: Epub 2022 Apr 9.

Nissim, N.R., Harvey, D.Y., Haslam, C., Friedman, L., Bharne, P., Litz, G., Phillips, J.S., Cousins, K.A.Q, Xie, S.X., Grossman, M., Hamilton, R.H.: Through thick and thin: Baseline cortical volume and thickness predict performance and response to tDCS in primary progressive aphasia Frontiers in Human Neuroscience 16: 907425, Jul 2022.

Dresang, H.C., Harvey, D.Y., Xie, S.X., Shah-Basak, P.P., DeLoretta, L., Wurzman, R., Parchure, S.Y., Sacchetti, D., Faseyitan, O., Lohoff, F.W., Hamilton, R.H.: Genetic and neurophysiological biomarkers of neuroplasticity inform post-stroke language recovery. Neurorehabilitation and Neural Repair 36(6): 371-380, Jun 2022.

Parchure, S.Y., Harvey, D.Y., Shah-Basak, P.P., DeLoretta, L., Wurzman, R., Sacchetti, D., Faseyitan, O., Lohoff, F.W., Hamilton, R.H.: Brain derived neurotrophic factor (BDNF) gene polymorphism predicts response to continuous theta burst stimulation (cTBS) in chronic stroke patients. Neuromodulation: Technology at the Neural Interface 25(4): 569-577, Jun 2022.

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Last updated: 04/08/2024
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