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Steven R. Messe, MD

Professor of Neurology at the Hospital of the University of Pennsylvania
Director, vascular neurology fellowship, Hospital of the University of Pennsylvania
Department: Neurology

Contact information
HUP Neurology
Dept. of Stroke and Neurocritical Care
3 W. Gates
Philadelphia, PA 19104
Office: (215) 662-3363
B.A. (Psychology)
Yale University, 1993.
MD (Medicine)
University of Michigan School of Medicine, 1998.
Post-Graduate Training
Intern, Hospital of the University of Pennsylvania, 1998-1999.
Resident, Hospital of the University of Pennsylvania, 1999-2002.
Fellow, Hospital of the University of Pennsylvania, 2002-2003.
American Board of Psychiatry and Neurology (Neurology), 2003.
American Board of Psychiatry and Neurology (Vascular Neurology), 2006.
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Description of Research Expertise

Dr. Messe has performed research on risk of carotid endarterectomy, tPA dosing errors, the management of patients with stroke and PFO, and neurologic outcomes from surgical and interventional procedures.

Description of Clinical Expertise

Dr. Messe specializes in caring for inpatients with acute stroke and neurologic illnesses requiring critical care. He is also a member of the intraoperative monitoring team providing neurophysiologic testing to surgical patients at risk of brain, spinal cord, or nerve injury. In the outpatient setting, he primarily cares for patients with stroke and cerebrovascular disease.

Selected Publications

Lansky Alexandra J, Messé Steven R, Brickman Adam M, Dwyer Michael, van der Worp H Bart, Lazar Ronald M, Pietras Cody G, Abrams Kevin J, McFadden Eugene, Petersen Nils H, Browndyke Jeffrey, Prendergast Bernard, Ng Vivian G, Cutlip Donald E, Kapadia Samir, Krucoff Mitchell W, Linke Axel, Moy Claudia Scala, Schofer Joachim, van Es Gerrit-Anne, Virmani Renu, Popma Jeffrey, Parides Michael K, Kodali Susheel, Bilello Michel, Zivadinov Robert, Akar Joseph, Furie Karen L, Gress Daryl, Voros Szilard, Moses Jeffrey, Greer David, Forrest John K, Holmes David, Kappetein Arie P, Mack Michael, Baumbach Andreas: Proposed Standardized Neurological Endpoints for Cardiovascular Clinical Trials: An Academic Research Consortium Initiative. Journal of the American College of Cardiology 69(6): 679-691, Feb 2017.

Mack Michael J, Acker Michael A, Gelijns Annetine C, Overbey Jessica R, Parides Michael K, Browndyke Jeffrey N, Groh Mark A, Moskowitz Alan J, Jeffries Neal O, Ailawadi Gorav, Thourani Vinod H, Moquete Ellen G, Iribarne Alexander, Voisine Pierre, Perrault Louis P, Bowdish Michael E, Bilello Michel, Davatzikos Christos, Mangusan Ralph F, Winkle Rachelle A, Smith Peter K, Michler Robert E, Miller Marissa A, O'Sullivan Karen L, Taddei-Peters Wendy C, Rose Eric A, Weisel Richard D, Furie Karen L, Bagiella Emilia, Moy Claudia Scala, O'Gara Patrick T, Messé Steven R: Effect of Cerebral Embolic Protection Devices on CNS Infarction in Surgical Aortic Valve Replacement: A Randomized Clinical Trial. JAMA 318(6): 536-547, 08 2017.

Messé Steven R, Mack Michael J: Improving Outcomes From Transcatheter Aortic Valve Implantation: Protecting the Brain From the Heart. JAMA 316(6): 587-8, Aug 2016.

Homma Shunichi, Messé Steven R, Rundek Tatjana, Sun Yee-Ping, Franke Jennifer, Davidson Karina, Sievert Horst, Sacco Ralph L, Di Tullio Marco R: Patent foramen ovale. Nature reviews. Disease primers 2: 15086, Jan 2016.

Messé Steven R, Khatri Pooja, Reeves Mathew J, Smith Eric E, Saver Jeffrey L, Bhatt Deepak L, Grau-Sepulveda Maria V, Cox Margueritte, Peterson Eric D, Fonarow Gregg C, Schwamm Lee H: Why are acute ischemic stroke patients not receiving IV tPA? Results from a national registry. Neurology 87(15): 1565-1574, Oct 2016.

Messé SR, McGarvey ML, Bavaria JE, Pochettino A, Szeto WY, Cheung AT, Leitner E, Miller SW, Kasner SE: A Pilot Study of Darbepoetin Alfa for Prophylactic Neuroprotection in Aortic Surgery. Neurocritical Care 18(1): 75-80, Feb 2013.

Raser J M, Mullen M T, Kasner S E, Cucchiara B L, Messé S R: Cervical carotid artery dissection is associated with styloid process length. Neurology 77(23): 2061-6, Dec 2011.

Messé Steven R, Kasner Scott E, Cucchiara Brett L, Demchuk Andrew, Tanne David, Ouyang Bichun, Levine Steven R, : Dosing errors did not have a major impact on outcome in the NINDS t-PA stroke study. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 20(3): 236-40, May-Jun 2011.

Messé Steven R, Ailawadi Gorav: Stroke After Transcatheter Aortic Valve Replacement: An Important but Underreported Outcome in Clinical Practice. JAMA 321(23): 2287-2289, 06 2019.

Elgendy, A. Y., Saver, J. L., Amin, Z., Boudoulas, K. D., Carroll, J. D., Elgendy, I. Y., Grunwald, I. Q., Gertz, Z. M., Hijazi, Z. M., Horlick, E. M., Kasner, S. E., Kent, D. M., Kumar, P., Kavinsky, C. J., Liebeskind, D. S., Lutsep, H., Mojadidi, M. K., Messé, S. R., Mas, J. L., Mattle, H. P., Meier, B., Mahmoud, A., Mahmoud, A. N., Nietlispach, F., Patel, N. K., Rhodes, J. F., Reisman, M., Sommer, R. J., Sievert, H., Søndergaard, L., Zaman, M. O., Thaler, D., Tobis, J. M., Mscai,: Proposal for Updated Nomenclature and Classification of Potential Causative Mechanism in Patent Foramen Ovale-Associated Stroke. JAMA Neurol 2020.

Messé, S. R., Gronseth, G. S., Kent, D. M., Kizer, J. R., Homma, S., Rosterman, L., Carroll, J. D., Ishida, K., Sangha, N., Kasner, S. E.: Practice advisory update summary: Patent foramen ovale and secondary stroke prevention: Report of the Guideline Subcommittee of the American Academy of Neurology. Neurology 94(20): 876-885, 2020.

Siegler, J. E., Rosenberg, J., Cristancho, D., Olsen, A., Pulst-Korenberg, J., Raab, L., Cucchiara, B., Messé, S. R.: Computed tomography perfusion in stroke mimics. Int J Stroke 15(3): 299-307, 2020.

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Last updated: 07/01/2022
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